Media Articles Related to Duramorph (Morphine Epidural)
Angola denies report that Dos Santos treated for cancer in Spain
Source: Yahoo Health News [2013.11.29]
Angola on Friday denied a report by Portuguese state TV that the oil-producing African state's long-serving President Jose Eduardo dos Santos was undergoing cancer treatment in Spain. "I don't have anything to say, because it is not ...
Untreated cancer pain a 'scandal of global proportions,' survey shows
Source: Health News from Medical News Today [2013.11.28]
A ground-breaking international collaborative survey, published in Annals of Oncology, shows that more than half of the world's population live in countries where regulations that aim to stem drug misuse leave cancer patients without access to opioid medicines for managing cancer pain.The results from the Global Opioid Policy Initiative (GOPI)  project show that more than 4 billion people live in countries where regulations leave cancer patients suffering excruciating pain.
Chest Pain in Women Looks a Lot Like Men's
Source: Medscape Nurses Headlines [2013.11.26]
A new review of almost 2500 emergency-department admissions suggests that the presentation of chest pain between men and women is not as different as is commonly thought.
9 Things Chronic Pain Specialists Want Hospitalists to Know
Source: Medscape Pharmacists Headlines [2013.11.26]
Read these useful pearls regarding opioid use and abuse, as well as tips regarding general pain management, from an expert team of chronic pain specialists.
Findings not supportive of using women-specific chest pain symptoms in early diagnosis of heart attack
Source: Cardiovascular / Cardiology News From Medical News Today [2013.11.26]
Using chest pain characteristics (CPCs) specific to women in the early diagnosis of acute myocardial infarction (AMI, heart attack) in the emergency department does not seem to be supported by the findings of a study published by JAMA Internal Medicine, a JAMA Network publication.
Published Studies Related to Duramorph (Morphine Epidural)
Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and
intrathecal morphine improves quality of pain control after total knee
arthroplasty: a randomized double-blind placebo controlled clinical trial. 
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal
Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a
double-blinded, randomized, placebo-controlled trial of sustained-release
morphine for treatment of chronic nonradicular low-back pain. 
Although often successful in acute settings, long-term use of opioid pain
medications may be accompanied by waning levels of analgesic response not readily
attributable to advancing underlying disease, necessitating dose escalation to
attain pain relief... Improvements in pain and functional ability were observed.
Tolerability and efficacy of two synergistic ratios of oral morphine and
oxycodone combinations versus morphine in patients with chronic noncancer pain. 
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)
Long-acting morphine following hip or knee replacement: a randomized,
double-blind and placebo-controlled trial. 
routine postoperative regimen for total hip or knee replacement surgery... CONCLUSIONS: Thirty milligrams twice per day of long-acting morphine from days 1
The effect of intravenous morphine on the level of spinal anesthesia with
CONCLUSION: Although some studies had proved the efficacy of systemic use of
Clinical Trials Related to Duramorph (Morphine Epidural)
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain
relief and side effect profiles of same in the setting of Total Knee Replacement. We
hypothesized that a dose greater than that used in Total Hip Replacement was needed and
wished to find a dose which was effective but had a low side effect profile.
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray
(MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo
in patients with moderate to severe post-surgical pain following orthopedic surgery. After
initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24)
hours will be evaluated. The rescue dose remained the same for each.
A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for
treating moderate to severe chronic pain over a 12 week period.
INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine
administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX)
and intravenously conducted in patients in a hospice care setting or through a palliative
care medicine setting. In this within-patient controlled study, each eligible study patient
receives a single injection by each of the three methods of morphine administration,
sequentially on three consecutive days, according to the order specified by a randomization
Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The
HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be
blinded, the two SC injections will be double-blinded, using the same volume of normal saline
(0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.