Duramorph (Morphine Sulfate Epidural) - Summary

DURAMORPH SUMMARY

DURAMORPH (morphine sulfate injection, USP)
PRESERVATIVE-FREE
CII
Rx only

Morphine is the most important alkaloid of opium and is a phenanthrene derivative.

Duramorph (Morphine EPIDURAL) is indicated for the following:

DURAMORPH is a systemic narcotic analgesic for administration by the intravenous, epidural or intrathecal routes. It is used for the management of pain not responsive to non-narcotic analgesics. DURAMORPH administered epidurally or intrathecally, provides pain relief for extended periods without attendant loss of motor, sensory or sympathetic function.

See all Duramorph indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Duramorph (Morphine Epidural)

Constant Pain a Big Problem in Older Adults (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.05.11]
NEW ORLEANS (MedPage Today) -- Nearly 19 million older adults in the U.S. reported bothersome pain in the previous month, according to researchers here.

Copper IUDs Not Associated With Increased Menstrual Pain
Source: Medscape Medical News Headlines [2013.05.10]
Copper IUDs are not linked with increased dysmenorrhea severity; a hormone-releasing system has been linked to reduced menstrual pain.
Medscape Medical News

Fun And Friends Help Ease The Pain Of Breast Cancer
Source: Health News from Medical News Today [2013.05.10]
Kaiser Permanente study among the first to examine how social relationships influence quality of life in breast cancer patients Breast cancer patients who say they have people to have a good time, or "positive social interactions," with are better able to deal with pain and other physical symptoms, according to a new Kaiser Permanente study published this week in Breast Cancer Research and Treatment. "This study provides research-based evidence that social support helps with physical symptoms," said lead author Candyce H...

Copper IUD Does Not Increase Period Pain
Source: Health News from Medical News Today [2013.05.10]
Previous scientific studies have suggested that women who use a copper IUD for contraception suffer from worse period pain, but a study at the Sahlgrenska Academy, University of Gothenburg, that followed 2,100 women over a 30-year period shows that this is not the case. In the study, 19-year-olds born in 1962, 1972 and 1982 were asked questions about their height, weight, pregnancies, children, period pain and contraception...

Inflammation Continues in Chronic Pain Patients (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.05.10]
NEW ORLEANS (MedPage Today) -- Even after long-term treatment with opioids, inflammation persists in many chronic pain patients as evidenced by C-reactive protein levels and erythrocyte sedimentation rate, a California researcher reported here.

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Published Studies Related to Duramorph (Morphine Epidural)

Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and intrathecal morphine improves quality of pain control after total knee arthroplasty: a randomized double-blind placebo controlled clinical trial. [2012]
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal

Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. [2012]
Although often successful in acute settings, long-term use of opioid pain medications may be accompanied by waning levels of analgesic response not readily attributable to advancing underlying disease, necessitating dose escalation to attain pain relief... Improvements in pain and functional ability were observed.

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Long-acting morphine following hip or knee replacement: a randomized, double-blind and placebo-controlled trial. [2012]
routine postoperative regimen for total hip or knee replacement surgery... CONCLUSIONS: Thirty milligrams twice per day of long-acting morphine from days 1

The effect of intravenous morphine on the level of spinal anesthesia with lidocaine. [2012]
CONCLUSION: Although some studies had proved the efficacy of systemic use of

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Clinical Trials Related to Duramorph (Morphine Epidural)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX) and intravenously conducted in patients in a hospice care setting or through a palliative care medicine setting. In this within-patient controlled study, each eligible study patient receives a single injection by each of the three methods of morphine administration, sequentially on three consecutive days, according to the order specified by a randomization schedule.

Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be blinded, the two SC injections will be double-blinded, using the same volume of normal saline (0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.

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