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Duramorph (Morphine Sulfate Epidural) - Summary

 
 



DURAMORPH SUMMARY

DURAMORPH (morphine sulfate injection, USP)
PRESERVATIVE-FREE
CII
Rx only

Morphine is the most important alkaloid of opium and is a phenanthrene derivative.

Duramorph (Morphine EPIDURAL) is indicated for the following:

DURAMORPH is a systemic narcotic analgesic for administration by the intravenous, epidural or intrathecal routes. It is used for the management of pain not responsive to non-narcotic analgesics. DURAMORPH administered epidurally or intrathecally, provides pain relief for extended periods without attendant loss of motor, sensory or sympathetic function.


See all Duramorph indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Duramorph (Morphine Epidural)

Watch for Axial Back Pain in Psoriatic Pts
Source: MedPageToday.com - medical news plus CME for physicians [2014.12.12]
(MedPage Today) -- Patients are more likely to have back pain, including spondyloarthritis.

A Virtual Refuge From Real Pain
Source: MedicineNet Chronic Pain Specialty [2014.12.12]
Title: A Virtual Refuge From Real Pain
Category: Health News
Created: 12/12/2014 12:00:00 AM
Last Editorial Review: 12/12/2014 12:00:00 AM

Ebola Vaccine Trial Halted Temporarily After Joint Pains
Source: Medscape Infectious Diseases Headlines [2014.12.11]
A clinical trial of an Ebola vaccine developed by Merck and NewLink has been halted temporarily as a precautionary measure after four patients complained of joint pains, the University of Geneva Hospital said.
Reuters Health Information

Pain Med Linked to Hypoglycemia
Source: Medscape NeurologyHeadlines [2014.12.11]
Tramadol, an opioid analgesic, was associated with an increased risk for hospitalization for hypoglycemia, especially in the first month of use, in a new study.
Medscape Medical News

Scientists chart spinal circuitry responsible for chronic pain
Source: Cancer / Oncology News From Medical News Today [2014.12.10]
Findings could lead to new therapeutics for disorders such as fibromyalgia and phantom limb painPain typically has a clear cause - but not always.

more news >>

Published Studies Related to Duramorph (Morphine Epidural)

Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery. [2014]
DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery...

Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial. [2014]
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of

The postoperative analgesic effect of morphine and paracetamol in the patients undergoing laparotomy, using PCA method. [2013]
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Effect of morphine on lower urinary tract discomfort after transurethral resection of prostate under general anesthesia: a randomised clinical study. [2013]
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces

more studies >>

Clinical Trials Related to Duramorph (Morphine Epidural)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX) and intravenously conducted in patients in a hospice care setting or through a palliative care medicine setting. In this within-patient controlled study, each eligible study patient receives a single injection by each of the three methods of morphine administration, sequentially on three consecutive days, according to the order specified by a randomization schedule.

Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be blinded, the two SC injections will be double-blinded, using the same volume of normal saline (0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.

more trials >>


Page last updated: 2014-12-12

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