Media Articles Related to Duramorph (Morphine Epidural)
Early Imaging Unhelpful in Older Adults With New Back Pain
Source: Medscape NeurologyHeadlines [2015.03.20]
A new study provides more evidence that early routine imaging for new-onset back pain in the elderly is costly and provides no benefit.
Medscape Medical News
Early imaging for back pain in older adults not associated with better outcomes
Source: Medical Devices / Diagnostics News From Medical News Today [2015.03.20]
Older adults who had spine imaging within 6 weeks of a new primary care visit for back pain had pain and disability over the following year that was not different from similar patients who did not...
Spinal cord neurons that control pain and itch
Source: Neurology / Neuroscience News From Medical News Today [2015.03.20]
The spinal cord transmits pain signals to the brain, where they are consciously perceived.
Stepped-Care Approach to Chronic Pain Improves Function
Source: Medscape Nurses Headlines [2015.03.19]
A two-step program combining analgesics, self-management strategies, and cognitive-behavioral therapy yields lasting improvement in chronic pain and function in a trial of US veterans.
Medscape Medical News
Minimally invasive spinal fusion: Less pain, faster recovery, smaller scar
Source: Bones / Orthopedics News From Medical News Today [2015.03.19]
A minimally invasive spinal fusion back surgery results in less blood loss, less postoperative pain, smaller incisions, a shorter hospital stay and faster recovery and return to work.
Published Studies Related to Duramorph (Morphine Epidural)
Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery. 
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery...
Morphine decreases clopidogrel concentrations and effects: a randomized,
double-blind, placebo-controlled trial. 
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of
The postoperative analgesic effect of morphine and paracetamol in the patients
undergoing laparotomy, using PCA method. 
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. 
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Effect of morphine on lower urinary tract discomfort after transurethral
resection of prostate under general anesthesia: a randomised clinical study. 
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces
Clinical Trials Related to Duramorph (Morphine Epidural)
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain
relief and side effect profiles of same in the setting of Total Knee Replacement. We
hypothesized that a dose greater than that used in Total Hip Replacement was needed and
wished to find a dose which was effective but had a low side effect profile.
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray
(MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo
in patients with moderate to severe post-surgical pain following orthopedic surgery. After
initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24)
hours will be evaluated. The rescue dose remained the same for each.
A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for
treating moderate to severe chronic pain over a 12 week period.
INFUSE Morphine Study [Completed]
Double-blind study comparing the pharmacokinetics, safety and tolerability of morphine
administered subcutaneously (SC) with and without human recombinant hyaluronidase (HYLENEX)
and intravenously conducted in patients in a hospice care setting or through a palliative
care medicine setting. In this within-patient controlled study, each eligible study patient
receives a single injection by each of the three methods of morphine administration,
sequentially on three consecutive days, according to the order specified by a randomization
Each of the three injections consists of 5 mg of morphine (1. 0 mL of 5 mg/mL solution). The
HYLENEX injection will be 1 mL of 150 units. Although the IV administration will not be
blinded, the two SC injections will be double-blinded, using the same volume of normal saline
(0. 9% sodium chloride) placebo (1. 0 mL) as HYLENEX.