Duo-Medihaler™
(isoproterenol hydrochloride and
phenylephrine bitartrate)
Inhalation Aerosol
PHARMACIST: Tear off ‘Patient Instructions for Use” and dispense with product.
Description
DUO-MEDIHALER (isoproterenol hydrochloride and phenylephrine bitartrate) is a combination of two sympathomimetics administered by oral inhalation for the treatment of bronchoconstriction. Each metered dose of the aerosol delivers through the oral adapter 0.16 mg isoproterenol hydrochloride and 0.24 mg phenylephrine bitartrate of appropriate particle size (the majority less than 5 μ). This drug product also cortains cetylpyridinium chloride, dichlorodifluoromethane, dichlorotetrafluoroethane, sorbitan trioleate, and trichloromonofluoromethane. Chemically, isoproterenol hydrochloride is 4-[1-hydroxy-2-[(1-methytethyl)amino]ethyl]-1,2-benzenediol hydrochloride and phenylephrine bitartrate is (-)- m -hydroxy- a -[(methylamino) methyl]benzyl alcohol bitartrate.
Structural formulae:
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