DUAC SUMMARY
Duac® Topical Gel contains clindamycin phosphate, (7(S)-chloro-7-deoxylincomycin-2-phosphate), equivalent to 1% clindamycin, and 5% benzoyl peroxide.
Duac Topical Gel is indicated for the topical treatment of inflammatory acne vulgaris.
Duac Topical Gel has not been demonstrated to have any additional benefit when compared to benzoyl peroxide alone in the same vehicle when used for the treatment of non-inflammatory acne.
|
|
NEWS HIGHLIGHTSMedia Articles Related to Duac (Clindamycin / Benzoyl Peroxide)
Health Tip: Four Common Types Of Acne Source: MedicineNet Acne Specialty [2017.09.20] Title: Health Tip: Four Common Types Of Acne Category: Health News Created: 9/20/2017 12:00:00 AM Last Editorial Review: 9/20/2017 12:00:00 AM
Acne (Pimples) Quiz: Test Your Medical IQ Source: MedicineNet Acne Specialty [2017.09.19] Title: Acne (Pimples) Quiz: Test Your Medical IQ Category: MedicineNet Quiz Created: 2/28/2011 4:15:00 PM Last Editorial Review: 9/19/2017 5:39:39 PM
Skin Quiz: Acne, Dry Skin, Dandruff & More Source: MedicineNet Acne Specialty [2017.09.19] Title: Skin Quiz: Acne, Dry Skin, Dandruff & More Category: MedicineNet Quiz Created: 10/7/2010 12:00:00 AM Last Editorial Review: 9/19/2017 5:01:04 PM
Health Tip: Can't Clear Your Acne? Source: MedicineNet Acne Specialty [2017.08.02] Title: Health Tip: Can't Clear Your Acne? Category: Health News Created: 8/2/2017 12:00:00 AM Last Editorial Review: 8/2/2017 12:00:00 AM
Acne 101: Types, Best Treatments, Medication, Cystic Acne Source: MedicineNet isotretinoin Specialty [2017.05.04] Title: Acne 101: Types, Best Treatments, Medication, Cystic Acne Category: Slideshows Created: 10/16/2014 12:00:00 AM Last Editorial Review: 5/4/2017 12:00:00 AM
Published Studies Related to Duac (Clindamycin / Benzoyl Peroxide)
Tazarotene versus tazarotene plus clindamycin/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial. [2006.03] Topical retinoids offer highly effective treatment for both inflammatory and non-inflammatory acne, with tazarotene demonstrating greater efficacy than other topical retinoids. A multicenter, double-blind, randomized, parallel-group trial has been performed to evaluate whether the adjunctive use of clindamycin/benzoyl peroxide could enhance the efficacy of tazarotene still further...
Comparison of clindamycin/benzoyl peroxide, tretinoin plus clindamycin, and the combination of clindamycin/benzoyl peroxide and tretinoin plus clindamycin in the treatment of acne vulgaris: a randomized, blinded study. [2005.09] In the treatment of mild to moderate acne vulgaris, the combination of an antibiotic and benzoyl peroxide provides enhanced efficacy over the individual agents, with the potential to decrease the emergence of resistant strains of P... In conclusion, the regimens that included clindamycin/benzoyl peroxide were more effective than tretinoin + clindamycin in the treatment of acne vulgaris, with no clinical advantage of adding tretinoin + clindamycin to once-daily clindamycin/benzoyl peroxide treatment.
Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination. [2005.03] This article will examine various clinical experiences with acne patients successfully treated with topical clindamycin 1% benzoyl peroxide 5% gel (Duac) alone and in combination with other acne treatments. Clindamycin 1% benzoyl peroxide 5%, the only once-daily prescription topical aqueous gel combining a benzoyl peroxide and an antibiotic, has demonstrated excellent tolerability and efficacy and is stable when used concomitantly with other therapies...
Twice-daily applications of benzoyl peroxide 5%/clindamycin 1% gel versus vehicle in the treatment of pseudofolliculitis barbae. [2004.06] Pseudofolliculitis barbae (PFB) is an inflammatory disorder characterized by the formation of papules, pustules, and hyperpigmentation as a result of ingrown hairs. It is estimated that PFB affects 45% to 83% of black men who shave regularly... These positive findings warrant further investigation of BP/C gel in the treatment of patients with PFB.
Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. [2004.06] A photographic analysis was conducted of results from a randomized, double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea... These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.
Clinical Trials Related to Duac (Clindamycin / Benzoyl Peroxide)
Evaluation of Quality of Life, Efficacy, and Tolerance of Duac� Gel Compared to Differin� Gel in the Treatment of Acne [Completed]
The objectives of this clinical trial are to compare the quality of life of the subjects,
the efficacy and the tolerance of Duac® Gel (gel formulation with a combination of
clindamycin phosphate [equivalent to 1% clindamycin] and 5% benzoyl peroxide), applied once
daily, against Differin® Gel (gel with 0. 1% adapalene), used once daily, in the treatment of
mild to moderate acne vulgaris.
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris [Completed]
The purpose of this study is to compare the effectiveness of two marketed products in
subjects with facial acne vulgaris
To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel [Recruiting]
This is an Randomized, Double-blind, Multicentric, Parallel-group, Active and Placebo
Controlled, Three Arm Clinical Study.
The main objective is to evaluate bioequivalence of Test formulation (Clindamycin Phosphate
1. 2%/Benzoyl peroxide 5% gel) of Cadila Healthcare with Reference formulation (DUAC® Gel of
Stiefel Laboratories)in the ratio of 2: 2:1 of Test drug, Reference drug and Placebo
respectively.
Total study duration will be for a period of 78 days which includes treatment duration of 77
days.
850 subjects will be enrolled (randomized)as per the inclusion and exclusion criteria
mentioned in the protocol.
A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac� Topical Gel in the Treatment of Acne Vulgaris [Completed]
The objective of this study is to compare the relative efficacy and safety of the test
formulation Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Taro Pharmaceuticals Inc.) to
the marketed formulation Duac® Topical Gel (Clindamycin 1%/Benzoyl Peroxide 5%) (Stiefel) in
the treatment of the inflamed lesions of acne vulgaris. Both the test and reference
formulations will also be compared to a placebo formulation to test for superiority.
A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne [Completed]
A study comparing the topical application of Aczone® plus Differin® versus Duac® plus
Differin® in patients with severe facial acne (facial acne vulgaris).
Reports of Suspected Duac (Clindamycin / Benzoyl Peroxide) Side Effects
Erythema (15),
Pruritus (11),
Urticaria (4),
Ill-Defined Disorder (4),
Eye Swelling (4),
Drug Ineffective (3),
Blister (3),
Product Quality Issue (3),
Swelling Face (3),
Rash (3), more >>
|
PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 7 ratings/reviews, Duac has an overall score of 6.43. The effectiveness score is 6.86 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Duac review by care giver of 17 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | acne |
Dosage & duration: | | topically (dosage frequency: once per day) for the period of 2 years |
Other conditions: | | none |
Other drugs taken: | | tazorac | | Reported Results |
Benefits: | | clear skin. limited break outs |
Side effects: | | Some dryness and redness unon initial use |
Comments: | | Initial treatment began with application of medication and then wiping it off after a period of time. Used inconjunction wiht a mild moisturizer and tazorac. Continued application was extended until product is applies before bedtime and not washed off. Used daily |
|
| Duac review by care giver of 17 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Moderately Effective |
Side effects: | | Moderate Side Effects | | Treatment Info |
Condition / reason: | | Acne |
Dosage & duration: | | Apply at bedtime (dosage frequency: once a day) for the period of about 9mos |
Other conditions: | | oily skin |
Other drugs taken: | | Differin | | Reported Results |
Benefits: | | Acne outbreaks healed quicker than using no medication. |
Side effects: | | At first my face was really red, dry, and flakey. After about 4 mos my face still gets red sometimes and is a little burny/itchy which it makes it hard to shave. |
Comments: | | When I started using Duac (at bedtime) it made my face red, dry, and it peeled. A great back-to-school look! I play outdoor sports and know I am suppose to wear suncreen but now all suncreens make my face burn(sting) more so I can't tolerate sunscreen. The slight sunburn is actually less painful. My acne seemed to heal the first 1-2 weeks and then it flaired up. It still flares but less frequently with less spots and heals faster. Biggest problem is that it's like bleach on my navy pillowcase and I have ruined a lot of dark colored towels |
|
| Duac review by 33 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Ineffective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | skin probles - acne, balckheads |
Dosage & duration: | | onse a day (dosage frequency: once a day) for the period of 3 months |
Other conditions: | | light allergies |
Other drugs taken: | | tazorac | | Reported Results |
Benefits: | | I could not observe any benefits: my blackheads remained as they were, and acne remained. Probably my problem was not severe enough to see the results, however, due to no observed change I stopped using it. |
Side effects: | | I have not noticed any side effects. Though I am susceptible to various allergies, I have not had any breakouts or worsening effects. Also, blackheads and acne did not become any worse. |
Comments: | | I was prescribed to use 2 cream gels - duac and tazorac. I was using small amount of each: duac as night cream, and tazorac as a day cream. |
|
|
Page last updated: 2017-09-20
|