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Duac (Clindamycin Phosphate / Benzoyl Peroxide) - Summary

 
 



DUAC SUMMARY

Duac® Topical Gel contains clindamycin phosphate, (7(S)-chloro-7-deoxylincomycin-2-phosphate), equivalent to 1% clindamycin, and 5% benzoyl peroxide.

Duac Topical Gel is indicated for the topical treatment of inflammatory acne vulgaris.

Duac Topical Gel has not been demonstrated to have any additional benefit when compared to benzoyl peroxide alone in the same vehicle when used for the treatment of non-inflammatory acne.


See all Duac indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Duac (Clindamycin / Benzoyl Peroxide)

Laser for tattoo removal appears to improve facial acne scarring
Source: Dermatology News From Medical News Today [2014.11.25]
A laser used to remove unwanted tattoos appears to improve facial acne scarring, according to a study published online by JAMA Dermatology.

Laser Used to Remove Tattoos May Help Reduce Acne Scars
Source: MedicineNet Acne Specialty [2014.11.20]
Title: Laser Used to Remove Tattoos May Help Reduce Acne Scars
Category: Health News
Created: 11/20/2014 12:00:00 AM
Last Editorial Review: 11/20/2014 12:00:00 AM

Acne (Pimples)
Source: MedicineNet Boils Specialty [2014.10.17]
Title: Acne (Pimples)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 10/17/2014 12:00:00 AM

Acne Pictures Slideshow: A Visual Dictionary
Source: MedicineNet Acne Specialty [2014.10.16]
Title: Acne Pictures Slideshow: A Visual Dictionary
Category: Slideshows
Created: 10/16/2014 12:00:00 AM
Last Editorial Review: 10/16/2014 12:00:00 AM

Health Tip: Help Prevent Acne Scars
Source: MedicineNet Acne Specialty [2014.10.01]
Title: Health Tip: Help Prevent Acne Scars
Category: Health News
Created: 10/1/2014 12:00:00 AM
Last Editorial Review: 10/1/2014 12:00:00 AM

more news >>

Published Studies Related to Duac (Clindamycin / Benzoyl Peroxide)

Tazarotene versus tazarotene plus clindamycin/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial. [2006.03]
Topical retinoids offer highly effective treatment for both inflammatory and non-inflammatory acne, with tazarotene demonstrating greater efficacy than other topical retinoids. A multicenter, double-blind, randomized, parallel-group trial has been performed to evaluate whether the adjunctive use of clindamycin/benzoyl peroxide could enhance the efficacy of tazarotene still further...

Comparison of clindamycin/benzoyl peroxide, tretinoin plus clindamycin, and the combination of clindamycin/benzoyl peroxide and tretinoin plus clindamycin in the treatment of acne vulgaris: a randomized, blinded study. [2005.09]
In the treatment of mild to moderate acne vulgaris, the combination of an antibiotic and benzoyl peroxide provides enhanced efficacy over the individual agents, with the potential to decrease the emergence of resistant strains of P... In conclusion, the regimens that included clindamycin/benzoyl peroxide were more effective than tretinoin + clindamycin in the treatment of acne vulgaris, with no clinical advantage of adding tretinoin + clindamycin to once-daily clindamycin/benzoyl peroxide treatment.

Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination. [2005.03]
This article will examine various clinical experiences with acne patients successfully treated with topical clindamycin 1% benzoyl peroxide 5% gel (Duac) alone and in combination with other acne treatments. Clindamycin 1% benzoyl peroxide 5%, the only once-daily prescription topical aqueous gel combining a benzoyl peroxide and an antibiotic, has demonstrated excellent tolerability and efficacy and is stable when used concomitantly with other therapies...

Twice-daily applications of benzoyl peroxide 5%/clindamycin 1% gel versus vehicle in the treatment of pseudofolliculitis barbae. [2004.06]
Pseudofolliculitis barbae (PFB) is an inflammatory disorder characterized by the formation of papules, pustules, and hyperpigmentation as a result of ingrown hairs. It is estimated that PFB affects 45% to 83% of black men who shave regularly... These positive findings warrant further investigation of BP/C gel in the treatment of patients with PFB.

Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. [2004.06]
A photographic analysis was conducted of results from a randomized, double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea... These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.

more studies >>

Clinical Trials Related to Duac (Clindamycin / Benzoyl Peroxide)

A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac� Topical Gel in the Treatment of Acne Vulgaris [Recruiting]
The objective of this study is to compare the relative efficacy and safety of the test formulation Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Taro Pharmaceuticals Inc.) to the marketed formulation Duac® Topical Gel (Clindamycin 1%/Benzoyl Peroxide 5%) (Stiefel) in the treatment of the inflamed lesions of acne vulgaris. Both the test and reference formulations will also be compared to a placebo formulation to test for superiority.

Study Comparing Clindamycin Phosphate and Benzoyl Peroxide Gel to Acanya� Gel and Both to a Vehicle Control in the Treatment of Acne Vulgaris [Recruiting]
The objective of this study is to compare the safety and efficacy profiles of Taro Pharmaceutical Inc.'s Clindamycin Phosphate and Benzoyl Peroxide Gel 1. 2%/2. 5% to Acanya® (Clindamycin Phosphate and Benzoyl Peroxide) Gel, 1. 2%/2. 5% and to demonstrate the superior efficacy of the two active formulations over that of the vehicle in the treatment of acne vulgaris.

Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris [Recruiting]
The purpose of this study is to compare the effectiveness of two marketed products in subjects with facial acne vulgaris

Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris [Recruiting]
This study is to determine the efficacy and safety of 12 week treatment with Differin® Gel 0. 3% applied in the evening, in combination with Duac® (Clindamycin/Benzoyl Peroxide Gel) applied in the morning, in Subjects with Acne vulgaris.

Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris [Completed]
Comparing the efficacy and safety of a gel formulation containing a combination of clindamycin phosphate (equivalent to 1% clindamycin) and benzoyl peroxide (5%) once daily with a gel containing 0. 1% adapalene once daily in the treatment of acne vulgaris of mild to moderate severity.

more trials >>

Reports of Suspected Duac (Clindamycin / Benzoyl Peroxide) Side Effects

Erythema (15)Pruritus (11)Urticaria (4)Ill-Defined Disorder (4)Eye Swelling (4)Drug Ineffective (3)Blister (3)Product Quality Issue (3)Swelling Face (3)Rash (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Duac has an overall score of 6.43. The effectiveness score is 6.86 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Duac review by care giver of 17 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   topically (dosage frequency: once per day) for the period of 2 years
Other conditions:   none
Other drugs taken:   tazorac
  
Reported Results
Benefits:   clear skin. limited break outs
Side effects:   Some dryness and redness unon initial use
Comments:   Initial treatment began with application of medication and then wiping it off after a period of time. Used inconjunction wiht a mild moisturizer and tazorac. Continued application was extended until product is applies before bedtime and not washed off. Used daily

 

Duac review by care giver of 17 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Acne
Dosage & duration:   Apply at bedtime (dosage frequency: once a day) for the period of about 9mos
Other conditions:   oily skin
Other drugs taken:   Differin
  
Reported Results
Benefits:   Acne outbreaks healed quicker than using no medication.
Side effects:   At first my face was really red, dry, and flakey. After about 4 mos my face still gets red sometimes and is a little burny/itchy which it makes it hard to shave.
Comments:   When I started using Duac (at bedtime) it made my face red, dry, and it peeled. A great back-to-school look! I play outdoor sports and know I am suppose to wear suncreen but now all suncreens make my face burn(sting) more so I can't tolerate sunscreen. The slight sunburn is actually less painful. My acne seemed to heal the first 1-2 weeks and then it flaired up. It still flares but less frequently with less spots and heals faster. Biggest problem is that it's like bleach on my navy pillowcase and I have ruined a lot of dark colored towels

 

Duac review by 33 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   skin probles - acne, balckheads
Dosage & duration:   onse a day (dosage frequency: once a day) for the period of 3 months
Other conditions:   light allergies
Other drugs taken:   tazorac
  
Reported Results
Benefits:   I could not observe any benefits: my blackheads remained as they were, and acne remained. Probably my problem was not severe enough to see the results, however, due to no observed change I stopped using it.
Side effects:   I have not noticed any side effects. Though I am susceptible to various allergies, I have not had any breakouts or worsening effects. Also, blackheads and acne did not become any worse.
Comments:   I was prescribed to use 2 cream gels - duac and tazorac. I was using small amount of each: duac as night cream, and tazorac as a day cream.

See all Duac reviews / ratings >>

Page last updated: 2014-11-25

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