DUAC SUMMARY
Duac® Topical Gel contains clindamycin phosphate, (7(S)-chloro-7-deoxylincomycin-2-phosphate), equivalent to 1% clindamycin, and 5% benzoyl peroxide.
Duac Topical Gel is indicated for the topical treatment of inflammatory acne vulgaris.
Duac Topical Gel has not been demonstrated to have any additional benefit when compared to benzoyl peroxide alone in the same vehicle when used for the treatment of non-inflammatory acne.
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NEWS HIGHLIGHTSMedia Articles Related to Duac (Clindamycin / Benzoyl Peroxide)
Health Tip: What's Triggering My Acne?
Source: MedicineNet Acne Specialty [2009.06.24]
Title: Health Tip: What's Triggering My Acne?
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
New Laser Combo Therapy Zaps Acne
Source: MedicineNet Acne Specialty [2009.03.09]
Title: New Laser Combo Therapy Zaps Acne
Category: Health News
Created: 3/7/2009 2:00:00 AM
Last Editorial Review: 3/9/2009
Acne Cream Not Linked to Raised Death Risk
Source: MedicineNet tretinoin Specialty [2009.01.26]
Title: Acne Cream Not Linked to Raised Death Risk
Category: Health News
Created: 1/24/2009 2:00:00 AM
Last Editorial Review: 1/26/2009
FDA OKs New Acne Gel Epiduo
Source: MedicineNet adapalene Specialty [2009.01.07]
Title: FDA OKs New Acne Gel Epiduo
Category: Health News
Created: 1/7/2009
Last Editorial Review: 1/7/2009
Acne (Pimples)
Source: MedicineNet Boils Specialty [2008.07.16]
Title: Acne (Pimples)
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 7/16/2008
Published Studies Related to Duac (Clindamycin / Benzoyl Peroxide)
Tazarotene versus tazarotene plus clindamycin/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial. [2006.03]
Topical retinoids offer highly effective treatment for both inflammatory and non-inflammatory acne, with tazarotene demonstrating greater efficacy than other topical retinoids. A multicenter, double-blind, randomized, parallel-group trial has been performed to evaluate whether the adjunctive use of clindamycin/benzoyl peroxide could enhance the efficacy of tazarotene still further...
Comparison of clindamycin/benzoyl peroxide, tretinoin plus clindamycin, and the combination of clindamycin/benzoyl peroxide and tretinoin plus clindamycin in the treatment of acne vulgaris: a randomized, blinded study. [2005.09]
In the treatment of mild to moderate acne vulgaris, the combination of an antibiotic and benzoyl peroxide provides enhanced efficacy over the individual agents, with the potential to decrease the emergence of resistant strains of P... In conclusion, the regimens that included clindamycin/benzoyl peroxide were more effective than tretinoin + clindamycin in the treatment of acne vulgaris, with no clinical advantage of adding tretinoin + clindamycin to once-daily clindamycin/benzoyl peroxide treatment.
Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination. [2005.03]
This article will examine various clinical experiences with acne patients successfully treated with topical clindamycin 1% benzoyl peroxide 5% gel (Duac) alone and in combination with other acne treatments. Clindamycin 1% benzoyl peroxide 5%, the only once-daily prescription topical aqueous gel combining a benzoyl peroxide and an antibiotic, has demonstrated excellent tolerability and efficacy and is stable when used concomitantly with other therapies...
Twice-daily applications of benzoyl peroxide 5%/clindamycin 1% gel versus vehicle in the treatment of pseudofolliculitis barbae. [2004.06]
Pseudofolliculitis barbae (PFB) is an inflammatory disorder characterized by the formation of papules, pustules, and hyperpigmentation as a result of ingrown hairs. It is estimated that PFB affects 45% to 83% of black men who shave regularly... These positive findings warrant further investigation of BP/C gel in the treatment of patients with PFB.
Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. [2004.06]
A photographic analysis was conducted of results from a randomized, double-blind, vehicle-controlled, 12-week study that assessed the efficacy of topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) versus vehicle in the treatment of rosacea... These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.
Clinical Trials Related to Duac (Clindamycin / Benzoyl Peroxide)
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris [Recruiting]
The purpose of this study is to compare the effectiveness of two marketed products in
subjects with facial acne vulgaris
Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris [Recruiting]
This study is to determine the efficacy and safety of 12 week treatment with Differin® Gel
0. 3% applied in the evening, in combination with Duac® (Clindamycin/Benzoyl Peroxide Gel)
applied in the morning, in Subjects with Acne vulgaris.
Comparison of Duac® Gel And Differin® Gel in Mild to Moderate Acne Vulgaris [Completed]
Comparing the efficacy and safety of a gel formulation containing a combination of
clindamycin phosphate (equivalent to 1% clindamycin) and benzoyl peroxide (5%) once daily
with a gel containing 0. 1% adapalene once daily in the treatment of acne vulgaris of mild to
moderate severity.
A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne [Recruiting]
Multi-center, single-blind, randomized, comparative, split-face study. The duration of the
study is 8 weeks. Commencing at baseline, subjects will apply once daily both clindamycin
and benzoyl peroxide gel and benzoyl peroxide/adapalene gel in a bilateral split-face
fashion (allocation to left and right side randomly assigned) for an initial 2 weeks. After
visit 3, subjects will commence application of clindamycin and benzoyl peroxide gel to the
entire face for an additional 6 weeks.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 5 ratings/reviews, Duac has an overall score of 6.60. The effectiveness score is 6.80 and the side effect score is 8.80. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Duac review by care giver of 17 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | topically (dosage frequency: once per day) for the period of 2 years |
| Other conditions: | | none |
| Other drugs taken: | | tazorac | | |
Reported Results |
| Benefits: | | clear skin. limited break outs |
| Side effects: | | Some dryness and redness unon initial use |
| Comments: | | Initial treatment began with application of medication and then wiping it off after a period of time. Used inconjunction wiht a mild moisturizer and tazorac. Continued application was extended until product is applies before bedtime and not washed off. Used daily |
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| | Duac review by care giver of 15 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | 1% / 5% (dosage frequency: daily) for the period of 3 months |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | Slight improvement of acne, but not enough to make it worth the treatment hassles. |
| Side effects: | | Product was gritty, drying and caused redness. Also was a bit smelly. When dropped onto the rug or clothing it caused bleach spots. |
| Comments: | | Had to apply the cream to dry, washed skin every day. It was supposed to show improvement withing a week or two, but it never helped very much at all. |
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| | Duac review by 33 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | skin probles - acne, balckheads |
| Dosage & duration: | | onse a day (dosage frequency: once a day) for the period of 3 months |
| Other conditions: | | light allergies |
| Other drugs taken: | | tazorac | | |
Reported Results |
| Benefits: | | I could not observe any benefits: my blackheads remained as they were, and acne remained. Probably my problem was not severe enough to see the results, however, due to no observed change I stopped using it. |
| Side effects: | | I have not noticed any side effects. Though I am susceptible to various allergies, I have not had any breakouts or worsening effects. Also, blackheads and acne did not become any worse. |
| Comments: | | I was prescribed to use 2 cream gels - duac and tazorac. I was using small amount of each: duac as night cream, and tazorac as a day cream. |
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Page last updated: 2009-06-24
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