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Dtic-Dome (Dacarbazine) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

DTIC-DOME drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Give supportive treatment and monitor blood cell counts.

CONTRAINDICATIONS

DTIC-Dome is contraindicated in patients who have demonstrated a hypersensitivity to it in the past.

REFERENCES

  1. Loo, T.J., et al.: Mechanism of action and pharmacology studies with DTIC (NSC-45388). Cancer Treatment Reports 60: 149-152, 1976.
  2. Nathanson, L., et al.: Characteristics of prognosis and response to an imidazole carboxamide in malignant melanoma. Clinical Pharmacology and Therapeutics 12: 955-962, 1971.
  3. Costanza, M.E., et al.: Therapy of malignant melanoma with an imidazole carboxamide and bischloroethyl nitrosourea. Cancer 30: 1457-1461, 1972.
  4. Luce, J.K., et al.: Clinical trials with the antitumor agent 5-(3, 3-dimethyl-l-triazeno) imidazole-4-carboxamide (NSC-45388). Cancer Chemotherapy Reports 54: 119-124, 1970.
  5. Bonadonna, G., et al.: Combined Chemotherapy (MOPP or ABVD)--radiotherapy approach in advanced Hodgkin's disease. Cancer Treatment Reports 61: 769-777, 1977.
  6. Santoro, A., and Bonadonna, G.: Prolonged disease-free survival in MOPP-resistant Hodgkin's disease after treatment with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). Cancer Chemotherapy Pharmacol. 2: 101-105, 1979.
  7. Recommendations for the Safe Handling of Parenteral Antineoplastic Drugs. NIH Publication No. 83-2621. For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402.
  8. AMA Council Report. Guidelines for Handling Parenteral Antineoplastics. JAMA, March 15, 1985.
  9. National Study Commission on Cytotoxic Exposure--Recommendations for Handling Cytotoxic Agents. Available from Louis P. Jeffrey, Sc. D., Director of Pharmacy Services, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02902.
  10. Clinical Oncological Society of Australia: Guidelines and recommendations for safe handling of antineoplastic agents. Med. J. Australia 1: 426-428, 1983.
  11. Jones, R.B., et al.: Safe handling of chemotherapeutic agents: A report from the Mount Sinai Medical Center. Ca-A Cancer Journal for Clinicians Sept./Oct. 258-263, 1983.
  12. American Society of Hospital Pharmacists technical assistance bulletin on handling cytotoxic drugs in hospitals. Am. J. Hosp. Pharm. 42: 131-137, 1985.

Manufactured by:

Ben Venue Laboratories

Bedford, Ohio 44146

Distributed by:

Bayer Pharmaceuticals Corporation

400 Morgan Lane

West Haven, CT 06516 USA

Rx Only

08844898, R.O5/0311778

© 2003 Bayer Pharmaceuticals Corporation

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