Cases of QT prolongation and/or torsade de pointes have been
reported in patients receiving droperidol at doses at or below recommended
doses. Some cases have occurred in patients with no known risk factors for
QT prolongation and some cases have been fatal.
to its potential for serious proarrhythmic effects and death, droperidol should
be reserved for use in the treatment of patients who fail to show an acceptable
response to other adequate treatments, either because of insufficient effectiveness
or the inability to achieve an effective dose due to intolerable adverse effects
from those drugs (see Warnings, Adverse Reactions, Contraindications, and
Cases of QT prolongation and serious
arrhythmias (e.g., torsade de pointes) have been reported in patients treated
with droperidol. Based on these reports, all patients should undergo a 12-lead
ECG prior to administration of droperidol to determine if a prolonged QT interval
(i.e., QTc greater than 440 msec for males or 450 msec for females) is present.
If there is a prolonged QT interval, droperidol should
be administered. For patients in whom the potential benefit of
droperidol treatment is felt to outweigh the risks of potentially serious
arrhythmias, ECG monitoring should be performed prior to treatment and continued
for 2-3 hours after completing treatment to monitor for arrhythmias.
is contraindicated in patients with known or suspected QT prolongation, including
patients with congenital long QT syndrome.
should be administered with extreme caution to patients who may be at risk
for development of prolonged QT syndrome (e.g., congestive heart failure,
bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia,
or administration of other drugs known to increase the QT interval). Other
risk factors may include age over 65 years, alcohol abuse, and use of agents
such as benzodiazepines, volatile anesthetics, and I.V. opiates. Droperidol
should be initiated at a low dose and adjusted upward, with caution, as needed
to achieve the desired effect.
Droperidol Injection, USP is a sterile, nonpyrogenic solution of droperidol in water for injection for intravenous or intramuscular injection. Each mL contains droperidol 2.5 mg. Contains lactic acid to adjust pH. pH is 3.4 (3.0 to 3.8).
The solution contains no bacteriostat, antimicrobial agent or added buffer and is intended only for use as a single-dose injection. Discard unused portion.
Droperidol injection is indicated to reduce the incidence
of nausea and vomiting associated with surgical and diagnostic procedures.
Published Studies Related to Droperidol
Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely
agitated patient: a multicenter, randomized, double-blind, placebo-controlled
clinical trial. 
rapid patient sedation... CONCLUSION: Intravenous droperidol or olanzapine as an adjunct to midazolam is
[Preoperative intravenous administration of droperidol (1.25 mg) reduced postoperative nausea and vomiting after intrathecal morphine administration]. [2011.02]
BACKGROUND: Intrathecal morphine (ITM) is an excellent postoperative analgesic, but may often cause postoperative nausea and vomiting (PONV). We designed this prospective, randomized and controlled study to evaluate the antiemetic efficacy of low-dose droperidol for the treatment of PONV caused by ITM... CONCLUSIONS: Single intravenous administration of 1.25 mg droperidol before operation showed prophylactic efficacy in early PONV caused by ITM. The duration of droperidol action was shorter than that of ITM. Hence we recommend that droperidol should be administered more frequently or continuously in the postoperative period.
A randomized comparison of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting. 
BACKGROUND: Nausea and vomiting are the most common causes of postoperative complications, and they are seen most often after operations performed using general anesthesia and sedation. We designed this study to compare the effects of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic operations... CONCLUSION: We conclude that metoclopramide is not effective in preventing postoperative nausea and vomiting after gynecologic operations. Droperidol, tropisetron, and ondansetron are effective; however, the sedating effects of droperidol and tropisetron should be considered. Copyright (c) 2010 S. Karger AG, Basel.
Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study. [2010.10]
STUDY OBJECTIVE: We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)... CONCLUSION: Intramuscular droperidol and midazolam resulted in a similar duration of violent and acute behavioral disturbance, but more additional sedation was required with midazolam. Midazolam caused more adverse effects because of oversedation, and there was no evidence of QT prolongation associated with droperidol compared with midazolam. Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.
Comparison between ketamine and fentanyl-droperidol for rectal premedication in children: a randomized placebo controlled trial. [2010.04]
PURPOSE: A common concern of anesthesiologists is the management of children involved in stressful scenarios, and premedication is considered, in most situations, as useful to reduce the stress responses. This randomized placebo-controlled study was designed to evaluate two premedicants, ketamine versus a combination of fentanyl-droperidol, rectally administered, in pediatric surgical outpatients... CONCLUSION: In this study, premedication with rectal ketamine showed significantly better overall results in the preoperative period than premedication with either fentanyl-droperidol or placebo.
Clinical Trials Related to Droperidol
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats [Completed]
We are investigating a new technique for testing the effect of drugs on electrical activity
in the heart. Disturbances of this electrical activity can cause life-threatening changes to
heart rhythms. A better way of measuring the risk has recently been developed, and our
research team leads the world in using this tool to test the safety of drugs used in
children. Children and their families want to know that the drugs being used are safe, as do
the doctors that care for them. In this study, we will take heartbeat tracings (ECGs) from
60 children before and during their operations. The ECGs will then be checked by a
children's heart specialist. Differences on the ECGs will be related to the presence and
amount of drug (droperidol or ondansetron) given. We expect that the droperidol or
ondansetron will not cause any changes that show increased risk of abnormal heart rhythms.
We can then tell patients, parents and regulatory authorities of the safety profile of this
aspect of the drug; moreover, the study can be used as a model for testing many other drugs
used in hospitals.
Evaluation of 2 Doses of Intravenous Droperidol in the Prevention of Postoperative Nausea [Terminated]
In this prospective, randomised, placebo-controlled study, the researchers determined
whether 0. 625 mg or 2. 5 mg of IV droperidol given 30 min before emergence from general
anaesthesia reduces the incidence of immediate and delayed post operative nausea and
vomiting (PONV) in thyroid surgical female population. Two hundred and forty six female
patients receiving general anaesthesia for thyroid surgery received either droperidol 0. 625
mg or droperidol 2. 5 mg or placebo before emergence.
Role of Droperidol in Postoperative Vomiting [Completed]
Protocol title: Role of low dose droperidol in postoperative vomiting
Purpose: Evaluate the efficacy of droperidol to postoperative nausea and vomiting when
administrated at the introduction to anesthesia, prior to surgery
Design: Prospective, randomized, placebo-controlled study
Patient Population: Male or female subjects 18 years of age or older who are scheduled for
No. of Subjects: 100 patients divided into two groups, estimated up to 6 months to enroll
Duration of Treatment: Prior operation
Duration of Follow-up: Follow-up will be performed for 24 hours postoperatively
Endpoints: To evaluate the effectiveness of low dose droperidol when administered Prior
Droperidol Versus Metoclopramide for the Treatment of Primary Headaches [Terminated]
Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis [Completed]
The purpose of this study is to evaluate the benefit of addition of droperidol to
prophylaxis with ondansetron and dexamethasone in children with high risk of postoperative
vomiting (POV). In adults some authors showed that the effectiveness of prophylaxis is
correlated to the number of molecules or specific procedures used.
Reports of Suspected Droperidol Side Effects
Blood Bilirubin Increased (3),
Abnormal Behaviour (3),
Hepatic Enzyme Increased (3),
Electrocardiogram QT Prolonged (2),
Unwanted Awareness During Anaesthesia (2),
Drug Ineffective (2),
Drug Hypersensitivity (2),
Ventricular Tachycardia (2), more >>
Page last updated: 2014-11-30