DRISDOL SUMMARY
DRISDOL, brand of ergocalciferol capsules, USP, is a synthetic calcium regulator for oral administration. Ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. It is affected by air and by light. Ergosterol or provitamin D2 is found in plants and yeast and has no antirachitic activity. There are more than 10 substances belonging to a group of steroid compounds, classified as having vitamin D or antirachitic activity. One USP unit of vitamin D2 is equivalent to one International Unit (IU), and 1 mcg of vitamin D2 is equal to 40 IU. Each capsule contains 1.25 mg (50,000 International Units vitamin D) of ergocalciferol, USP, in an edible vegetable oil.
DRISDOL is indicated for use in the treatment of hypoparathyroidism, refractory rickets, also known as vitamin D resistant rickets, and familial hypophosphatemia.
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NEWS HIGHLIGHTS
Published Studies Related to Drisdol (Ergocalciferol)
Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light. [2009.06]
BACKGROUND: The optimal treatment for correcting or preventing vitamin D insufficiency in cystic fibrosis (CF) patients has not been established. OBJECTIVE: The aim of the study was to assess the relative efficacy of three modes of vitamin D therapy: cholecalciferol (D3), ergocalciferol (D2), and UV light in raising or maintaining 25(OH)D levels above 30 ng/ml... CONCLUSION: This study demonstrates that CF subjects are able to achieve or maintain optimal vitamin D status (>30 ng/ml) with two oral regimens of either D3 or D2 treatment, the former being more efficacious. A confounding variable for this observation is the fact that the D3 and D2 capsules contained different carriers, powder-based vs. oil-based, respectively. UV therapy did not alter vitamin D status, possibly due to poor adherence to UV therapy.
Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women. [2008.01.14]
BACKGROUND: Ergocalciferol (vitamin D(2)) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling... CONCLUSION: Patients with a history of falling and vitamin D insufficiency living in sunny climates benefit from ergocalciferol supplementation in addition to calcium, which is associated with a 19% reduction in the relative risk of falling, mostly in winter.
Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease. [2007.03.20]
BACKGROUND: There is a high incidence of hip fractures in patients with Parkinson disease (PD). Bone mineral density (BMD) is decreased in patients with PD, correlating with the immobilization-induced bone resorption and hypovitaminosis D with compensatory hyperparathyroidism. OBJECTIVE: To evaluate the effectiveness of risedronate, an inhibitor of bone resorption, on osteoporosis and the risk of hip fractures in elderly men with PD... CONCLUSION: Treatment with risedronate and vitamin D2 increases bone mineral density in elderly men with Parkinson disease and reduces the risk of hip fractures.
Risedronate sodium therapy for prevention of hip fracture in men 65 years or older after stroke. [2005.08.08]
BACKGROUND: There is a high incidence of hip fractures in patients after hemiplegic stroke. Bone mineral density is decreased on the hemiplegic side in patients after stroke, correlating with the immobilization-induced bone resorption, the degree of paralysis, and hypovitaminosis D. The purpose of this study is to evaluate the effectiveness of risedronate sodium, an inhibitor of bone resorption, on osteoporosis and the risk of hip fractures in men 65 years or older after stroke... CONCLUSION: Treatment with risedronate increases bone mineral density and reduces hip fractures in elderly men who are poststroke.
Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. [2009.11]
Vitamin D insufficiency is commonly associated with hip fracture. However, the equipotency of ergocalciferol and cholecalciferol supplementation in this patient group has not been studied in a randomized trial using high-performance liquid chromatography (HPLC) measurement of serum 25-hydroxyvitamin D (25OHD)...
Clinical Trials Related to Drisdol (Ergocalciferol)
Clinical Approaches to Correcting Vitamin D Inadequacy and Maintaining Adequacy [Active, not recruiting]
Vitamin D is available in two forms, vitamin D2 and vitamin D3. It has previously been
assumed that these two forms maintain blood vitamin D equally. However, this may not be the
case. This study will evaluate whether D2 and D3 produce equal elevation of blood vitamin D.
Additionally, it will evaluate whether once per month vitamin D dosing is as effective in
maintaining blood vitamin D levels as daily dosing.
Vitamin D Levels and Vitamin D Education in Geriatric Patients [Completed]
Vitamin D is important to maintain good health. Although it is found in foods and vitamins,
many people still have low vitamin D levels. One purpose of this study is to describe
vitamin D levels from patients at the University of Colorado Seniors Clinic. Another goal of
the study is to find out if education by a pharmacist can increase vitamin D levels in
patients who have low vitamin D levels.
Randomized Study of Exercise and Vitamin D in Frail Elderly Subjects. [Terminated]
The study will explore multiple mobility function tests as well as functional and
neuropsychological tests in elderly subjects at risk for falls and disability, before and
after 4-month exercise and/or Vitamin D intervention.
The Effect of Vitamin D on Bone Accretion and Turn-Over in Young Girls [Completed]
Objectives To evaluate the effect of increased vitamin D intake on vitamin D status, bone
mass and bone turnover in young girls aged 12-13.
More specifically the effects on the following parameters will be assessed:
- Vitamin D metabolites.
- Parathyroid hormone.
- Bone turnover.
- Bone mineral accretion.
- Serum calcium and phosphate.
- Renal handling of calcium and phosphate.
Oral Vitamin D Supplementation in Elderly Women [Completed]
The aim of this study is to compare oral vitamin D supplementation administered in two
different ways, namely either twice a day (800IU/d, 292000IU/y) or three times a year
(97333IU every 4 months, 292000IU/y) in elderly women in combination with daily
supplementation of calcium 1 gram. We will 1)compare the blood concentrations of 25 OH
vitamin D in the two treatment groups amd monitor if a sufficient and safe concentration of
25OH D in blood can be maintained with these two treatments. 2) Find out seasonal variation in
vitamin D concentrations in these treatments. 3) Find out safety of these treatments
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Page last updated: 2009-10-20
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