Doxycycline (Doxycycline Hyclate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. These reactions have been caused by both the oral and parenteral administration of tetracyclines.

Skin: Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS).

Renal Toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS).

Hypersensitivity Reactions: urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, pericarditis and exacerbation of systemic lupus erythematosus.

Bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving full therapeutic dosages. These conditions disappeared rapidly when the drug was discontinued.

Blood: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported.

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function studies are known to occur.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO DOXYCYCLINE

Possible Doxycycline side effects / adverse reactions in 46 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-01-11

Patient: 46 year old male

Reactions: Liver Function Test Abnormal

Adverse event resulted in: hospitalization

Suspect drug(s):
Doxycycline

Other drugs received by patient: Aspirin; Ciprofloxacin; Humalog; Insulin Glargine; Losartan Potassium; Simvastatin

Possible Doxycycline side effects / adverse reactions in 17 year old male

Reported by a individual with unspecified qualification from United States on 2007-01-17

Patient: 17 year old male weighing 74.3 kg (163.5 pounds)

Reactions: RED Cell Distribution Width Increased, Neutrophil Count Increased, Drug Ineffective, Pain in Extremity, Oedema Peripheral, Iron Deficiency, Platelet Count Increased, Deep Vein Thrombosis

Adverse event resulted in: hospitalization

Suspect drug(s):
Sulfamethoxazole and Trimethoprim
    Dosage: 1 tablet, twice daily, oral
    Administration route: Oral
    Indication: Acne
    Start date: 2006-09-01
    End date: 2006-11-30

Doxycycline
    Dosage: 100 mg, twice daily, oral
    Administration route: Oral
    Indication: Acne
    Start date: 2006-11-30
    End date: 2006-12-08

Possible Doxycycline side effects / adverse reactions in 24 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-01-26

Patient: 24 year old female weighing 63.0 kg (138.6 pounds)

Reactions: Dysphagia, Dyspepsia

Suspect drug(s):
Doxycycline

Other drugs received by patient: Microgynon