Doxycycline (Doxycycline Hyclate) - Description

For IV Infusion Only

Rx ONLY

To reduce the development of drug-resistant bacteria and maintain the effectiveness of doxycycline and other antibacterial drugs, doxycycline should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DESCRIPTION

Doxycycline for Injection USP is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a light yellow crystalline powder, and is available as doxycycline hydrochloride hemiethanolate hemihydrate. Chemically, doxycycline is 4-(DimethyIamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate. Doxycycline has a high degree of lipoid solubiIity and a low affinity for calcium binding. It is highly stable in normal human serum. Each vial contains a sterile mixture of doxycycline hyclate equivalent to 100 mg doxycycline and 480 mg ascorbic acid.

The structural formula of Doxycycline Hyclate is as follows:

(C₂₂H₂₄N₂O₈•HCl)₂•C₂H₅O•H₂O                                                         M.W.=1025.87