Doryx (Doxycycline Hyclate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Due to oral doxycycline’s virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported rarely. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed (see DOSAGE AND ADMINISTRATION).

Skin: Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above (see WARNINGS).

Renal toxicity: Rise in BUN has been reported and is apparently dose-related (see WARNINGS).

Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

Other: Bulging fontanels in infants and benign intracranial hypertension in adults (See PRECAUTIONS- General).

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function are known to occur.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO DORYX

Possible Doryx side effects / adverse reactions in 17 year old male

Reported by a consumer/non-health professional from United States on 2007-01-31

Patient: 17 year old male

Reactions: Weight Increased, Telangiectasia, Drug Interaction, Thrombocythaemia, Convulsive Threshold Lowered, Local Swelling, Fall, Convulsion

Suspect drug(s):
Adderall XR 10
    Dosage: 20mg in the morning

Doryx

Fluoxetine
    Dosage: 10mg in the morning

Lamictal
    Dosage: 300mg twice per day
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2004-01-01

Other drugs received by patient: M.v.i.

Possible Doryx side effects / adverse reactions in 78 year old female

Reported by a consumer/non-health professional from United States on 2007-01-31

Patient: 78 year old female

Reactions: Sensory Disturbance, Dehydration

Adverse event resulted in: hospitalization

Suspect drug(s):
Doryx

Possible Doryx side effects / adverse reactions in 17 year old male

Reported by a individual with unspecified qualification from United States on 2007-02-22

Patient: 17 year old male

Reactions: Telangiectasia, Thrombocythaemia, Drug Interaction, Convulsive Threshold Lowered, Local Swelling, Fall, Convulsion, Grand MAL Convulsion, Mental Impairment, Weight Increased, Unequal Limb Length, Complex Partial Seizures

Adverse event resulted in: hospitalization

Suspect drug(s):
Doryx

Lamictal
    Indication: Epilepsy

Trileptal
    Start date: 2002-01-01

Other drugs received by patient: Adderall XR (Amfetamine Aspartate, Amfetamine Sulfate, Dexamfetamine S; Fluoxetine; Multivitamins (Ascorbic Acid, Ergocalciferol, Folic Acid, Nicotinamide