DOSAGE AND ADMINISTRATION
Concentration-dependent pharmacokinetics prevail when DOLOBID is administered; a doubling of dosage produces a greater than doubling of drug accumulation. The effect becomes more apparent with repetitive doses.
For mild to moderate pain, an initial dose of 1000 mg followed by 500 mg every 12 hours is recommended for most patients. Following the initial dose, some patients may require 500 mg every 8 hours.
A lower dosage may be appropriate depending on such factors as pain severity, patient response, weight, or advanced age; for example, 500 mg initially, followed by 250 mg every 8-12 hours.
For osteoarthritis and rheumatoid arthritis, the suggested dosage range is 500 mg to 1000 mg daily in two divided doses. The dosage of DOLOBID may be increased or decreased according to patient response.
Maintenance doses higher than 1500 mg a day are not recommended.
DOLOBID may be administered with water, milk or meals. Tablets should be swallowed whole, not crushed or chewed.
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