DESCRIPTION
Diflunisal is 2', 4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid. Its empirical formula is C13H8F2O3 and its structural formula is:
Diflunisal has a molecular weight of 250.20. It is a stable, white, crystalline compound with a melting point of 211-213°C. It is practically insoluble in water at neutral or acidic pH. Because it is an organic acid, it dissolves readily in dilute alkali to give a moderately stable solution at room temperature. It is soluble in most organic solvents including ethanol, methanol, and acetone.
DOLOBID * (Diflunisal) is available in 250 and 500 mg tablets for oral administration. Tablets DOLOBID contain the following inactive ingredients: cellulose, FD&C Yellow 6 hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, starch, talc, and titanium dioxide.
*Registered trademark of MERCK & CO., INC.
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