NEWS HIGHLIGHTS
Published Studies Related to Dolobid (Diflunisal)
Single dose oral diflunisal for acute postoperative pain in adults. [2010]
CONCLUSIONS: Diflunisal has an analgesic effect similar to other NSAIDs
A comparison of two nonsteroidal antiinflammatory drugs (diflunisal versus dipyrone) in the treatment of moderate to severe cancer pain: a randomized crossover study. [1998.04]
The efficacy of diflunisal in cancer pain was evaluated and compared with dipyrone. Diflunisal was given at the dosage of 500 mg perorally twice a day, and dipyrone was given at the dosage of 500 mg perorally three times a day...
Clinical effects of diflunisal and paracetamol in impacted mandibular third molar surgery. [1997.09]
A double-blind, randomized, cross-over study to compare diflunisal and paracetamol for postoperative pain, swelling and trismus relief following impacted mandibular third molar surgery was designed...
Comparison of the analgesic effects of diflunisal and paracetamol in the treatment of postoperative dental pain. [1996]
The search for new effective analgesics without unwanted effects on the coagulation mechanism and a longer duration of activity has been intensified. One such development is diflunisal and the aim of this study was to compare the analgesic effect of diflunisal with that of paracetamol... The results showed a statistically significant difference in favour of diflunisal in each and every parameter used in determining the efficacy of the treatment.
Pre-operative diflunisal for pain relief following third molar surgery under general anaesthesia. [1993.04]
In order to find out whether long-acting non-narcotic analgesics given pre-operatively reduce the post-operative pain and decrease the narcotic analgesic requirements following third molar surgery under general anaesthesia, thirty Hong Kong Chinese patients undergoing this procedure were randomly given either diflunisal or placebo one hour prior to anaesthesia...
Clinical Trials Related to Dolobid (Diflunisal)
Pilot Study of Diflunisal in HIV-infected Adults [Recruiting]
Diflunisal is an anti-inflammatory drug (like ASA or ibuprofen) that has been used as a
painkiller for 20 years. Recent research shows that it may have an anti-HIV effect in the
laboratory. Approximately 20 HIV-infected adults who are not receiving antiretroviral
therapy will be given diflunisal by mouth twice daily for 4 weeks, at a dose that has been
shown to be safe when used to treat pain. Subjects will be monitored closely for safety and
will have frequent blood tests during the study to see if the drug has any effect on the
level of HIV in their blood.
The Effect of Diflunisal on Familial Transthyretin Amyloidosis [Recruiting]
An ongoing trial of diflunisal has been closed for enrollment, thus, patients suitable for
the study can no longer participate or receive treatment by diflunisal; and patients, who
have participated in the trial can not continue their treatment. The investigators want to
continue to monitor the effect of the drug on TTR amyloidosis in an open label observational
study.
Primary endpoint will be a composite score of the manifestations of the disease (Kumamoto
scale) and secondary end points will be measurements of neurological impairment, heart
involvement and nutritional status.
The Effect of Diflunisal on Familial Amyloidosis [Recruiting]
The purpose of this study is to determine if diflunisal can prevent progressive lower leg
nerve damage in patients with familial amyloidosis polyneuropathy.
Study of CRx-401 on Glucose Levels in Subjects With Type II Diabetes [Recruiting]
This trial will assess the efficacy of CRx-401 in lowering FPG levels in patients taking
metformin to treat their diabetes. In addition, this initial trial will evaluate insulin
resistance (HOMA-IR index), HgbA1c levels, glycated protein, LDL, HDL, triglycerides, and
total cholesterol, as well as the safety of CRx-401.
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