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Diuril I.V. (Chlorothiazide Sodium Intravenous) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

When given concurrently the following drugs may interact with thiazide diuretics.

Alcohol, barbiturates, or narcotics --potentiation of orthostatic hypotension may occur.

Antidiabetic drugs --(oral agents and insulin)--dosage adjustment of the antidiabetic drug may be required.

Other antihypertensive drugs --additive effect or potentiation.

Corticosteroids, ACTH --intensified electrolyte depletion, particularly hypokalemia.

Pressor amines (e.g., norepinephrine) --possible decreased response to pressor amines but not sufficient to preclude their use.

Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine) --possible increased responsiveness to the muscle relaxant.

Lithium --generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. Refer to the package insert for lithium preparations before use of such preparations with Sodium DIURIL.

Non-steroidal Anti-inflammatory Drugs --In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Sodium DIURIL and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

OVERDOSAGE

The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias.

In the event of overdosage, symptomatic and supportive measures should be employed. Correct dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. If required, give oxygen or artificial respiration for respiratory impairment.

The degree to which chlorothiazide sodium is removed by hemodialysis has not been established.

The intravenous LD50 of chlorothiazide in the mouse is 1.1 g/kg.

CONTRAINDICATIONS

Anuria.

Hypersensitivity to any component of this product or to other sulfonamide-derived drugs.

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