Diupres (Reserpine / Chlorothiazide) - Indications and Dosage

INDICATIONS AND USAGE

Hypertension (see box warning).

DOSAGE AND ADMINISTRATION

The initial dosage of DIUPRES should conform to the dosages of the individual components established during titration (see box warning).

The usual adult dosage of DIUPRES-250 is 1 or 2 tablets once or twice a day; that of DIUPRES-500 is 1 tablet once or twice a day.

Dosage may require adjustment according to the blood pressure response of the patient. For maintenance, dosage should be adjusted to the lowest requirement of the individual patient. Doses higher than 0.25 mg daily of reserpine should be used cautiously, because occurrence of serious mental depression and other side effects may increase considerably (see WARNINGS).

HOW SUPPLIED

No. 3261 — Tablets DIUPRES-250 are pink, round, scored, compressed tablets, coded MSD 230 on one side and DIUPRES on the other. Each tablet contains 250 mg of chlorothiazide and 0.125 mg of reserpine. They are supplied as follows:

NDC 0006-0230-68 in bottles of 100

NDC 0006-0230-82 in bottles of 1000.

No. 3262 — Tablets DIUPRES-500 are pink, round, scored, compressed tablets, coded MSD 405 on one side and DIUPRES on the other. Each tablet contains 500 mg of chlorothiazide and 0.125 mg of reserpine. They are supplied as follows:

NDC 0006-0405-68 in bottles of 100

NDC 0006-0405-82 in bottles of 1000.

Storage

Keep container tightly closed. Protect from light, moisture, freezing, -20°C (-4°F) and store at room temperature, 15-30°C (59-86°F).

Dist. by: MERCK & CO., Inc., West Point, PA 19486, USA

Issued March 1995

Printed in USA

7900347