DIUPRESRegistered trademark of MERCK & CO., Inc., COPYRIGHT © MERCK & CO., Inc., 1986 All rights reserved combines two antihypertensives: DIURIL (Chlorothiazide) and reserpine.
Chlorothiazide is a diuretic and antihypertensive. Its chemical name is 6-chloro-2 H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2 and its structural formula is:
Chlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 295.73, which is very slightly soluble in water, but readily soluble in dilute aqueous sodium hydroxide. It is soluble in urine to the extent of about 150 mg per 100 mL at pH 7.
The chemical name of reserpine is 11, 17α-dimethoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-3β, 20α-yohimban-16β-carboxylic acid methyl ester. It is a crystalline alkaloid derived from Rauwolfia serpentina. Its empirical formula is C33H40N2O9 and its structural formula is:
Reserpine is a white or pale buff to slightly yellowish, odorless, crystalline powder with a molecular weight of 608.69, is insoluble in water and freely soluble in glacial acetic acid.
DIUPRES is supplied as tablets in two strengths for oral use:
DIUPRES-250, contains 250 mg of chlorothiazide and 0.125 mg of reserpine.
DIUPRES-500, contains 500 mg of chlorothiazide and 0.125 mg of reserpine,
Each tablet contains the following inactive ingredients: FD&C Red 3, gelatin, lactose, magnesium stearate, starch and talc.