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Ditropan (Oxybutynin Chloride) - Summary

 
 



DITROPAN SUMMARY

DITROPAN®
(oxybutynin chloride)
Tablets and Syrup

Each scored biconvex, engraved blue DITROPAN® (oxybutynin chloride) Tablet contains 5 mg of oxybutynin chloride. Each 5 mL of DITROPAN Syrup contains 5 mg of oxybutynin chloride.

DITROPAN® (oxybutynin chloride) is indicated for the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria).


See all Ditropan indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Ditropan (Oxybutynin)

A phase 2, randomized, double-blind, efficacy and safety study of oxybutynin vaginal ring for alleviation of overactive bladder symptoms in women. [2014]
vaginal ring in women with overactive bladder... CONCLUSIONS: The oxybutynin vaginal ring appears to be an effective and safe once

Desmopressin and oxybutynin in monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors. [2012]
evaluated... CONCLUSIONS: Our findings highlight that anticholinergic agents may play an

Efficacy of oral extended-release oxybutynin in cognitively impaired older nursing home residents with urge urinary incontinence: a randomized placebo-controlled trial. [2011.11]
OBJECTIVES: To determine the efficacy of oral extended-release oxybutynin for urge urinary incontinence in older female nursing home residents with mild to severe cognitive impairment... CONCLUSION: Extended-release oxybutynin 5 mg per day for 4 weeks in older cognitively impaired female nursing home residents did not significantly reduce urinary incontinence and urinary frequency or achieve dryness. Participants with mild to moderate cognitive and/or physical impairment were no more likely to benefit from oxybutynin than more severely impaired individuals in an exploratory analysis but further research in a larger population and perhaps using a larger dose is needed. Copyright (c) 2011 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.

Tolerability of solifenacin and oxybutynin immediate release in older (> 65 years) and younger (</= 65 years) patients with overactive bladder: sub-analysis from a Canadian, randomized, double-blind study. [2011.02]
CONCLUSIONS: Solifenacin 5 mg/day was better tolerated than oxybutynin IR 15 mg/day in younger (</= 65 years) and older (> 65 years) subgroups. Solifenacin was equally well tolerated in both age subgroups. Limitations of the analysis were that the study was not preplanned to perform post-hoc subgroup analysis, patients knew that dry mouth was a primary outcome, and the study used fixed doses of each drug.

[Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder]. [2011.01]
OBJECTIVE: To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children... CONCLUSIONS: Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.

more studies >>

Clinical Trials Related to Ditropan (Oxybutynin)

A Study Comparing the Efficacy and Safety of OROS® Oxybutynin to That of Ditropan® (Immediate-Release Oxybutynin) for the Treatment of Patients With Urge or Mixed Urinary Incontinence. [Completed]
The purpose of this study is to compare the efficacy and safety of OROS® oxybutynin to that of Ditropan® (immediate-release oxybutynin) for the treatment of patients with urge or mixed urinary incontinence. Oxybutynin is an antispasmodic, anticholinergic medication for the treatment of the symptoms of overactive bladder.

Fasting Study of Oxybutynin Chloride ER Tablets 10 mg and Ditropan XL® Tablets 10 mg [Completed]
The objective of this study was to investigate the single-dose relative bioavailability of Mylan's oxybutynin chloride extended-release tablets to ALZA's Ditropan XL® tablets following an oral, single 20 mg (2 x 10 mg) dose under fasting conditions.

Food Study of Oxybutynin Chloride ER Tablets 10 mg and Ditropan XL® Tablets 10 mg [Completed]
The objective of this study was to investigate the single-dose relative bioavailability of Mylan's oxybutynin chloride extended-release tablets to ALZA's Ditropan XL® tablets following an oral, single 20 mg (2 x 10 mg) dose under fed conditions.

Fed Study of Oxybutynin Chloride Extended-Release Tablets 10 mg and Ditropan XL® Tablets 10 mg [Completed]
The objective of this study was to investigate the single-dose relative bioavailability of Mylan's oxybutynin chloride extended-release tablets to ALZA's Ditropan XL® tablets following an oral, single 20 mg (2 x 10 mg) dose under fed conditions.

Food Study of Oxybutynin Chloride Extended-Release Tablets 5 mg and Ditropan XL® Tablets 5 mg [Completed]
The objective of this study was to investigate the single-dose relative bioavailability of Mylan's oxybutynin chloride extended-release tablets to ALZA's Ditropan XL® tablets following an oral, single 20 mg (4 x 5 mg) dose under fed conditions.

more trials >>

Reports of Suspected Ditropan (Oxybutynin) Side Effects

Confusional State (6)Cognitive Disorder (5)Parkinsonism (4)Leukoencephalopathy (4)Iatrogenic Injury (4)Cerebral Atrophy (4)Fall (3)Dizziness (3)Convulsion (3)Tremor (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ditropan has an overall score of 4.33. The effectiveness score is 6.67 and the side effect score is 5.33. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ditropan review by care giver of 6 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   incontinence
Dosage & duration:   2x 5ml daily (dosage frequency: 2x daily) for the period of 1 month
Other conditions:   urge incontinence, wetting at night
Other drugs taken:   n/a
  
Reported Results
Benefits:   The medicine has stopped her wetting both day and night and worked within a week of her taking it. She is over the moon and so am I!
Side effects:   My daughter complains of a pain in her bladder area and some constipation and her face looks a little flushed. I am considering lowering the dose to 2x 2.5ml per day
Comments:   She has had 4 years of bladder infections and has had various scans and tests. I think that she has never been able to read the signals from her bladder properly due to all the infections. This medicine which was prescribed by the dr on a trial basis seems to be working well. We will try to wean her off it slowly after a little while

 

Ditropan review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Hyperhidrosis
Dosage & duration:   1 pill 3 times a day taken every day for the period of around 2 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   stopped sweating, but the drying effect brought a very dry mouth and throat as well as side effect
Side effects:   very dry thoat and eyes, dry mouth, burning sensation when urinating.
Comments:   the drug is not to treat hyperhidrosis, but it's its side effects that the drug was being taken for - namely the drying up for hyperhidrosis

 

Ditropan review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Hyperhidrosis
Dosage & duration:   1 pill 3 times a day taken every day for the period of around 2 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   stopped sweating, but the drying effect brought a very dry mouth and throat as well as side effect
Side effects:   very dry thoat and eyes, dry mouth, burning sensation when urinating.
Comments:   the drug is not to treat hyperhidrosis, but it's its side effects that the drug was being taken for - namely the drying up for hyperhidrosis

See all Ditropan reviews / ratings >>

Page last updated: 2014-11-30

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