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Dipyridamole (Dipyridamole) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Adverse reactions at therapeutic doses are usually minimal and transient. On long-term use of dipyridamole tablets initial side effects usually disappear. The following reactions in Table 1 were reported in two heart valve replacement trials comparing dipyridamole tablets and warfarin therapy to either warfarin alone or warfarin and placebo:

Table 1Adverse Reactions Reported in 2 Heart Valve Replacement Trials
Adverse  Reaction
Dipyridamole  Tablets /
Warfarin
Placebo /
Warfarin
Number of patients
147
170
Dizziness
13.6%
8.2%
Abdominal distress
6.1%
3.5%
Headache
2.3%
0.0%
Rash
2.3%
1.1%

Other reactions from uncontrolled studies include diarrhea, vomiting, flushing and pruritus. In addition, angina pectoris has been reported rarely and there have been rare reports of liver dysfunction. On those uncommon occasions when adverse reactions have been persistent or intolerable, they have ceased on withdrawal of the medication.

When dipyridamole tablets were administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone. In rare cases, increased bleeding during or after surgery has been observed.

In post-marketing reporting experience, there have been rare reports of hypersensitivity reactions (such as rash, urticaria, severe bronchospasm, and angioedema), larynx edema, fatigue, malaise, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, thrombocytopenia, alopecia, cholelithiasis, hypotension, palpitation, and tachycardia.



REPORTS OF SUSPECTED DIPYRIDAMOLE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Dipyridamole. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dipyridamole side effects / adverse reactions in 81 year old male

Reported by a consumer/non-health professional from France on 2011-10-07

Patient: 81 year old male

Reactions: White Blood Cell Count Decreased, Platelet Count Decreased, Hyponatraemia, Drug Level Decreased, Anaemia Macrocytic, Convulsion

Adverse event resulted in: hospitalization

Suspect drug(s):
Diltiazem HCL
    Administration route: Oral

Dipyridamole
    Administration route: Oral

Furosemide
    Administration route: Oral

Prazosin HCL
    Administration route: Oral

Tamsulosin HCL
    Administration route: Oral

Valproate Sodium
    Administration route: Oral
    Indication: Convulsion



Possible Dipyridamole side effects / adverse reactions in 81 year old male

Reported by a consumer/non-health professional from France on 2011-10-07

Patient: 81 year old male

Reactions: Hyponatraemia, Neutropenia, Drug Level Decreased, Thrombocytopenia, Convulsion, Anaemia Macrocytic, Leukopenia

Adverse event resulted in: hospitalization

Suspect drug(s):
Depakene
    Dosage: 500 mg, 2x/day
    Administration route: Oral
    Indication: Convulsion
    Start date: 1999-08-19
    End date: 2001-10-16

Diltiazem HCL
    Administration route: Oral

Dipyridamole
    Administration route: Oral

Lasix
    Dosage: 40 mg daily
    Administration route: Oral

Prazosin HCL
    Administration route: Oral

Tamsulosin HCL
    Administration route: Oral

Other drugs received by patient: Celiprolol



Possible Dipyridamole side effects / adverse reactions in 67 year old female

Reported by a physician from United Kingdom on 2011-10-21

Patient: 67 year old female

Reactions: Haemorrhage, Tachycardia, Hypotension, Glomerulonephritis Rapidly Progressive, Ascites, Haemoglobin Decreased, Muscle Haemorrhage, Microscopic Polyangiitis, Arterial Rupture

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Dipyridamole



See index of all Dipyridamole side effect reports >>

Drug label data at the top of this Page last updated: 2011-04-29

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