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Diprivan (Propofol) - Summary



DIPRIVAN® (Propofol) Injectable Emulsion, USP is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration.

DIPRIVAN Injectable Emulsion is an IV sedative-hypnotic agent that can be used as described in the table below. 


                                      Table 3.  Indications for DIPRIVAN Injectable Emulsion


Approved Patient Population

Initiation and maintenance of Monitored Anesthesia Care (MAC) sedation

Adults only

Combined sedation and regional anesthesia

Adults only (see PRECAUTIONS )

Induction of General Anesthesia

Patients ≥ 3 years of age

Maintenance of General Anesthesia

Patients ≥ 2 months of age

Intensive Care Unit (ICU) sedation of intubated, mechanically ventilated patients

Adults only

Safety, effectiveness and dosing guidelines for DIPRIVAN Injectable Emulsion have not been established for MAC Sedation in the pediatric population; therefore, it is not recommended for this use (see PRECAUTIONS,   Pediatric Us e ).

DIPRIVAN Injectable Emulsion is not recommended for induction of anesthesia below the age of 3 years or for maintenance of anesthesia below the age of 2 months because its safety and effectiveness have not been established in those populations.

In the Intensive Care Unit (ICU), DIPRIVAN Injectable Emulsion can be administered to intubated, mechanically ventilated adult patients to provide continuous sedation and control of stress responses only by persons skilled in the medical management of critically ill patients and trained in cardiovascular resuscitation and airway management.

DIPRIVAN Injectable Emulsion is not indicated for use in Pediatric ICU sedation since the safety of this regimen has not been established (see PRECAUTIONS,   Pediatric Us e ).

DIPRIVAN Injectable Emulsion is not recommended for obstetrics, including Cesarean section deliveries.  DIPRIVAN Injectable Emulsion crosses the placenta, and as with other general anesthetic agents, the administration of DIPRIVAN Injectable Emulsion may be associated with neonatal depression (see PRECAUTIONS ).

DIPRIVAN Injectable Emulsion is not recommended for use in nursing mothers because propofol has been reported to be excreted in human milk, and the effects of oral absorption of small amounts of propofol are not known (see PRECAUTIONS ).

See all Diprivan indications & dosage >>


Published Studies Related to Diprivan (Propofol)

Electroconvulsive therapy pre-treatment with low dose propofol: comparison with unmodified treatment. [2014]
CONCLUSION: Whilst unmodified ECT should never be used when modified ECT under

Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial. [2014]
with that of lidocaine... CONCLUSIONS: 0.15 mg/kg cisatracurium effectively decreases the incidence and

Comparison of dexmedetomidine and propofol for conscious sedation in awake craniotomy: a prospective, double-blind, randomized, and controlled clinical trial. [2013]
sedation in awake craniotomy... CONCLUSIONS: Either DEX or PRO can be effectively and safely used for conscious

Reducing the pain of microemulsion propofol injections: a double-blind, randomized study of three methods of tourniquet and lidocaine. [2013]
of tourniquet application and lidocaine administration on MP injection pain... CONCLUSIONS: We concluded that intravenous retention of lidocaine with the

Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy. [2012]
The aim of this study was to evaluate the effect of a ketamine:propofol combination ('ketofol') for electroconvulsive therapy on seizure activity, haemodynamic response and recovery parameters, and to compare with these with the effects of propofol alone...

more studies >>

Clinical Trials Related to Diprivan (Propofol)

Comparison of Different Propofol Formulations [Recruiting]
The objective of this study is to evaluate the influence of different propofol formulations(plain or with lidocaine)on anesthetic induction. Propofol plain or with lidocaine is administered using a closed-loop algorithm in order to reach a Bispectral Index target of 50.

Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma [Completed]
The hypothesis of the study is that propofol-fentanyl sedation for lumbar punctures in children with acute leukemia/lymphoma results in fewer adverse events than propofol sedation alone. Secondary hypotheses state that propofol-fentanyl sedation results in a better sedation induction, recovery profile and is preferred by patients/families. The study is a double blind, randomized, placebo controlled crossover study. Following the induction phase of chemotherapy, children will be randomized in a crossover manner to receive either fentanyl-propofol or propofol-placebo for future lumbar punctures. Patients will be studied on two separate occasions, once with propofol-placebo (normal saline) and once with propofol-fentanyl. Children will be monitored continuously by pulse oximetry, electrocardiogram (ECG) and direct nursing and physician observation during the sedation in accordance with the University of Wisconsin (UW) Pediatric Policy and Procedure. Propofol will be titrated to a Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) score of ≤ 7 for all children. Oxygen saturation, respiratory rate, heart rate and blood pressure will be recorded every 3 minutes by a study investigator during sedation.

Compare Pharmaco-economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia [Not yet recruiting]
This study is performed to demonstrate that the direct anesthetic costs of a low fresh gas flow balanced sevoflurane anesthesia for elective laparoscopy are less compared to the direct anesthetic costs of a target-controlled infusion anesthesia based on propofol.

A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters [Recruiting]
This is a pilot study to compare the hemodynamic changes that occur during induction with a novel drug combination known as ketofol (propofol and ketamine admixture with that of propofol alone (prototypic anesthesia induction agent). Propofol and ketamine are widely used as induction agents and their effects on patient hemodynamics are well known. Some of these drug-induced hemodynamic changes are undesirable and lead to deleterious effects on patient hemodynamics. We seek to investigate the hemodynamic changes associated with a novel drug combination known as ketofol (ketamine/propofol admixture) during induction and compare them to propofol. If we determine that the changes produced by ketofol are favorable compared with propofol, we then will seek to test its use in the trauma setting in a subsequent randomized controlled trial.

COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-Heart Operations [Suspended]
The aim of the study is to prove if general anesthesia with inhaled sevoflurane reduces the frequency of neurological and cognitive impairment after open-heart operations with use of cardiopulmonary by-pass (CPB) in comparison with intravenous anesthesia with propofol.

more trials >>

Reports of Suspected Diprivan (Propofol) Side Effects

Anaphylactic Shock (73)Bronchospasm (19)Erythema (17)Cardiac Arrest (14)Hypotension (13)Circulatory Collapse (12)Bradycardia (12)Shock (12)Blood Pressure Decreased (11)Tachycardia (10)more >>

Page last updated: 2014-11-30

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