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Diphenoxylate and Atropine (Diphenoxylate Hydrochloride / Atropine Sulfate) - Summary



Diphenoxylate hydrochloride is an antidiarrheal. Atropine sulfate is an anticholinergic.


Diphenoxylate hydrochloride and atropine sulfate tablets are effective as adjunctive therapy in the management of diarrhea.

See all Diphenoxylate and Atropine indications & dosage >>


Media Articles Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids
Source: Immune System / Vaccines News From Medical News Today [2017.08.14]
Following the introduction of routine childhood vaccination against rotavirus, a common cause of diarrheal illness, more than 380,000 children avoided hospitalization for diarrhea from 2008 to 2013...

Six foods that cause diarrhea
Source: Nutrition / Diet News From Medical News Today [2017.08.11]
In this article, learn about six foods that may contribute to diarrhea and how to tell if diarrhea is due to food. What treatments are recommended?

BRAT diet: Benefits, risks, and treating diarrhea
Source: Flu / Cold / SARS News From Medical News Today [2017.07.07]
What is the BRAT diet, how does the BRAT diet work, and is it effective? Learn if the diet is safe, when to see a doctor, and what foods to avoid.

Source: MedicineNet Addison Disease Specialty [2017.03.21]
Title: Diarrhea
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 3/21/2017 12:00:00 AM

HIV and diarrhea: Causes, treatment, and remedies
Source: Irritable Bowel Syndrome News From Medical News Today [2017.03.12]
What is the connection between diarrhea and HIV, when might it occur, and how long does it last? Are there any complications with HIV and diarrhea?

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Published Studies Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.

Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.

Diphenoxylate-atropine (Lomotil) overdose in children: an update (report of eight cases and review of the literature) [1991.05]
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This overdose is primarily an opioid intoxication, occasionally associated with atropine toxicity.Recommended treatment is intravenous naloxone for depressed or inadequate respirations, followed by continuous intravenous naloxone infusion, prompt gastric lavage, repeated administration of activated charcoal, and close monitoring for 24 hours.

Effect of liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) instillations on dynamics and function of continent cecal urinary reservoirs. [1987.10]
We assessed the impact of twice daily instillations of 10 ml...

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Clinical Trials Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging. This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In addition, bowel activity can also hinder interpretation of PET scans in other types of solid tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans for newly diagnosed or recurrent, untreated lymphoma.

A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001 [Withdrawn]
MP-101 will be evaluated in this study to see if it is safe and tolerable.

A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals [Withdrawn]
MP-101 will be evaluated in this study to see if it is safe, tolerable, and can help people with Short Bowel Syndrome. This study will also find out if taking MP-101 can improve the symptoms of Short Bowel Syndrome and reduce the number of times subjects experience bowel movements.

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Page last updated: 2017-08-14

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