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Diphenoxylate and Atropine (Diphenoxylate Hydrochloride / Atropine Sulfate) - Summary

 
 



SUMMARY

Diphenoxylate hydrochloride is an antidiarrheal. Atropine sulfate is an anticholinergic.

DIPHENOXYLATE AND ATROPINE (DIPHENOXYLATE/ATROPINE) is indicated for the following:

Diphenoxylate hydrochloride and atropine sulfate tablets are effective as adjunctive therapy in the management of diarrhea.


See all Diphenoxylate and Atropine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

When to Call the Doctor for Fever, Nausea, Diarrhea, Colds, and Coughs
Source: MedicineNet Bruises Specialty [2016.12.01]
Title: When to Call the Doctor for Fever, Nausea, Diarrhea, Colds, and Coughs
Category: Doctor's & Expert's views on Symptoms
Created: 12/20/2010 12:00:00 AM
Last Editorial Review: 12/1/2016 12:00:00 AM

IBS-D (Irrititable Bowel Syndrome with Diarrhea)
Source: MedicineNet Laxatives For Constipation Specialty [2016.08.10]
Title: IBS-D (Irrititable Bowel Syndrome with Diarrhea)
Category: Diseases and Conditions
Created: 8/10/2016 12:00:00 AM
Last Editorial Review: 8/10/2016 12:00:00 AM

Addicts Using Diarrhea Drug Imodium to Get High
Source: MedicineNet Poison Control Centers Specialty [2016.05.06]
Title: Addicts Using Diarrhea Drug Imodium to Get High
Category: Health News
Created: 5/5/2016 12:00:00 AM
Last Editorial Review: 5/6/2016 12:00:00 AM

Travelers' Diarrhea
Source: MedicineNet Giardia Lamblia Specialty [2016.03.16]
Title: Travelers' Diarrhea
Category: Diseases and Conditions
Created: 4/3/1999 12:00:00 AM
Last Editorial Review: 3/16/2016 12:00:00 AM

Diarrhea
Source: MedicineNet Giardia Lamblia Specialty [2015.10.29]
Title: Diarrhea
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 10/29/2015 12:00:00 AM

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Published Studies Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis. [2009.03]
CONCLUSIONS: Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon.

Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. [2008.01]
Lomotil (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view.

Diphenoxylate-atropine (Lomotil) overdose in children: an update (report of eight cases and review of the literature) [1991.05]
Eight pediatric accidental overdoses of diphenoxylate-atropine (Lomotil) are reported, and 28 literature cases are reviewed. This overdose is primarily an opioid intoxication, occasionally associated with atropine toxicity.Recommended treatment is intravenous naloxone for depressed or inadequate respirations, followed by continuous intravenous naloxone infusion, prompt gastric lavage, repeated administration of activated charcoal, and close monitoring for 24 hours.

Effect of liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) instillations on dynamics and function of continent cecal urinary reservoirs. [1987.10]
We assessed the impact of twice daily instillations of 10 ml...

more studies >>

Clinical Trials Related to Diphenoxylate and Atropine (Diphenoxylate / Atropine)

Diphenoxylate / Atropine to Decrease FDG Activity During F-18 FDG PET [Completed]
2-[18F]-fluoro-2-deoxyD-glucose positron emission tomography (FDG PET) has proven to be a valuable clinical tool for the staging and surveillance of lymphoma. 1-6 Occasionally, lymph nodes in the mesentery and retroperitoneum can be difficult to distinguish from normal bowel activity on PET scans despite three-plane and cine maximal image projection (MIP) imaging. This uncertainty limits the clinical usefulness of PET in some cases of lymphoma. 7-8 In addition, bowel activity can also hinder interpretation of PET scans in other types of solid tumors including melanoma and colorectal cancer. 6,9,10 Our goal is to determine how well diphenoxylate/atropine 5mg/0. 05mg (Lomotil) decreases bowel activity and how this decrease impacts clinical decision-making, specifically for lymphoma staging and surveillance. This is a prospective, randomized, double-blinded study involving 60 patients undergoing PET scans for newly diagnosed or recurrent, untreated lymphoma.

A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001 [Withdrawn]
MP-101 will be evaluated in this study to see if it is safe and tolerable.

A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals [Withdrawn]
MP-101 will be evaluated in this study to see if it is safe, tolerable, and can help people with Short Bowel Syndrome. This study will also find out if taking MP-101 can improve the symptoms of Short Bowel Syndrome and reduce the number of times subjects experience bowel movements.

more trials >>


Page last updated: 2016-12-01

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