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Diphenhydramine (Diphenhydramine Hydrochloride) - Summary

 

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SUMMARY

DIPHENHYDRAMINE HYDROCHLORIDE
INJECTION, USP

Diphenhydramine Hydrochloride Injection is a sterile, nonpyrogenic solution for intravenous or deep intramuscular use as an antihistaminic agent. Each mL contains diphenhydramine hydrochloride 50 mg and benzethonium chloride 100 mcg in Water for Injection. pH 4.0-6.5; sodium hydroxide and/or hydrochloric acid added, if needed, for pH adjustment.

Diphenhydramine Hydrochloride Injection is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when the oral form is impractical:

Antihistaminic

For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standardmeasures after the acute symptoms have been controlled and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.

Motion Sickness

For active treatment of motion sickness.

Antiparkinsonism

For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents, mild cases of parkinsonism in other age groups and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

NEWS HIGHLIGHTS RELATED TO DIPHENHYDRAMINE

Published Studies Related to Diphenhydramine

A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. [2008.07.30]

Effects of 2-Week Treatment With Temazepam and Diphenhydramine in Elderly Insomniacs: A Randomized, Placebo-Controlled Trial. [2008.04]

Lorazepam, diphenhydramine, and haloperidol transdermal gel for rescue from chemotherapy-induced nausea/vomiting: results of two pilot trials. [2008.01]

Efficacy of diphenhydramine against cough in humans: a review. [2007.12]

Midazolam vs. Diphenhydramine for the Treatment of Metoclopramide-induced Akathisia: A Randomized Controlled Trial. [2007.08]

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Clinical Trials Related to Diphenhydramine

To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Doses [Completed]

Bioequivalence Between Two Oral Formulations of Diphenhydramine Hydrochloride [Completed]

Post Burn Pruritus Study in Patients Undergoing Wound Healing [Completed]

Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy in Young Patients With Newly Diagnosed Cancer [Recruiting]

Evaluation of Treatment Satisfaction in Children With an Allergy and Who Received an Antihistamine [Not yet recruiting]

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Page last updated: 2008-08-10

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