DILT-CD SUMMARY
DILT-CD
(Diltiazem Hydrochloride Extended-Release Capsules, USP) (Once-a-day dosage) 120 mg, 180 mg, 240 mg and 300 mg
Diltiazem hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist).
DILT-CD (Diltiazem Hydrochloride Extended-Release Capsules, USP) (Once-a-day dosage) are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive medications.
DILT-CD (Diltiazem Hydrochloride Extended-Release Capsules, USP) (Once-a-day dosage) are indicated for the management of chronic stable angina and angina due to coronary artery spasm.
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NEWS HIGHLIGHTS
Published Studies Related to Dilt-CD (Diltiazem)
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. [2009.10]
Objective: To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure...
Effect of diltiazem on kidney function during laparoscopic surgery. [2009.08]
BACKGROUND: Pneumoperitoneum is known to be associated with transient impairment in kidney function. This study was designed to investigate the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery... CONCLUSION: Continuous infusion of diltiazem 2 microg/kg/min prevented the decrease in CrCl during pneumoperitoneum without hemodynamic derangement. Although the decrease in CrCl was transient in patients with normal kidney function in this study, diltiazem may be used to prevent further kidney injury in those with elevated CrCl during laparoscopic surgery.
Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. [2009.07]
OBJECTIVES: To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization... CONCLUSIONS: As compared with digoxin and amiodarone, intravenous diltiazem was safe and effective in achieving VR control to improve symptoms and to reduce hospital stay in patients with acute AF.
Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: a prospective randomized trial. [2009.01]
AIM: To assess the efficacy of internal sphincterotomy compared with application of topical 2% Diltiazem ointment after hemorrhoidectomy for pain relief. SETTINGS AND DESIGN: Prospective randomized study... CONCLUSIONS: In patients undergoing hemorrhoidectomy, addition of surgical internal sphincterotomy results in lesser pain in the postoperative period as compared to those receiving topical application of Diltiazem.
Influence of grape juice and orange juice on the pharmacokinetics and pharmacodynamics of diltiazem in healthy human male subjects. [2008.10]
CONCLUSIONS: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem.
Clinical Trials Related to Dilt-CD (Diltiazem)
Food Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg [Completed]
The objective for this study was to investigate the bioequivalence of Mylan's verapamil HCl
extended-release 300 mg capsules to Schwarz's Verelan® PM extended-release 300 mg capsules
following a single, oral 300 mg (1 x 300 mg) dose administration under fed conditions.
Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's verapamil HCl
extended-release 300 mg capsules to Schwarz's Verelan® PM extended-release 300 mg capsules
following evening administration of a single, oral 300 mg (1 x 300 mg) dose under fasting
conditions.
Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg to Verelan® PM Extended-Release Capsules 300 mg [Completed]
The objective for this study was to investigate the bioequivalence of Mylan's verapamil HCl
extended-release 300 mg capsules to Schwarz's Verelan® PM extended-release 300 mg capsules
following evening administration of a single, oral 300 mg (1 x 300 mg) dose administration
under fasting conditions.
Fasting Applesauce Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's verapamil HCl
extended-release 300 mg capsules to Schwarz's Verelan® PM extended-release 300 mg capsules
following by a single, oral 300 mg (1 x 300 mg) dose administration sprinkled on one
tablespoon of applesauce under fasting conditions.
The Effect of Concomitant Administration of Erythromycin and Diltiazem on CYP3A Activity in Healthy Volunteers [Completed]
We, the researchers at the Indiana University School of Medicine, are doing this study to
better understand how the effects of certain medications are altered when taken
simultaneously, or in combination with each other. We will also look at how each volunteer's
genes (DNA) may affect the way these medications are metabolized.
Hypothesis:
We will test the hypothesis that the extent of drug-drug interaction caused by the
combination of erythromycin and diltiazem is not predictable from the extent of interaction
produced by each inhibitor alone. Specifically we will test the hypothesis that the
combination of erythromycin and diltiazem will cause a greater decrease in midazolam
intravenous and oral clearance than the sum of the decreases caused by each inhibitor alone.
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