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Dilaudid-HP (Hydromorphone Hydrochloride) - Side Effects and Adverse Reactions



The major hazards of DILAUDID-HP include respiratory depression and apnea. To a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest have occurred.

The most frequently observed adverse effects are lightheadedness, dizziness, sedation, nausea, vomiting, sweating, flushing, dysphoria, euphoria, dry mouth, and pruritus. These effects seem to be more prominent in ambulatory patients and in those not experiencing severe pain.

Less Frequently Observed Adverse Reactions

General and CNS

Weakness, headache, agitation, tremor, uncoordinated muscle movements, alterations of mood (nervousness, apprehension, depression, floating feelings, dreams), muscle rigidity, paresthesia, muscle tremor, blurred vision, nystagmus, diplopia and miosis, transient hallucinations and disorientation, visual disturbances, insomnia, increased intracranial pressure


Flushing of the face, chills, tachycardia, bradycardia, palpitation, faintness, syncope, hypotension, hypertension


Bronchospasm and laryngospasm


Constipation, biliary tract spasm, ileus, anorexia, diarrhea, cramps, taste alterations


Urinary retention or hesitancy, antidiuretic effects


Urticaria, other skin rashes, wheal and flare over the vein with intravenous injection, diaphoresis


In clinical trials, neither local tissue irritation nor induration was observed at the site of subcutaneous injection of DILAUDID-HP; pain at the injection site was rarely observed. However, local irritation and induration have been seen following parenteral injection of other opioid drug products.


Below is a sample of reports where side effects / adverse reactions may be related to Dilaudid-HP. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dilaudid-HP side effects / adverse reactions in 58 year old female

Reported by a consumer/non-health professional from United States on 2011-12-22

Patient: 58 year old female

Reactions: Cardiac Discomfort

Suspect drug(s):

Possible Dilaudid-HP side effects / adverse reactions in 64 year old female

Reported by a consumer/non-health professional from United States on 2012-06-07

Patient: 64 year old female

Reactions: Drug Hypersensitivity, Amnesia

Adverse event resulted in: disablity

Suspect drug(s):

Possible Dilaudid-HP side effects / adverse reactions in 49 year old male

Reported by a physician from United States on 2012-07-16

Patient: 49 year old male

Reactions: Burning Sensation, Back Pain, Drug Tolerance, Pain, Intervertebral Disc Degeneration, Gait Disturbance, Abscess, Muscle Spasms

Adverse event resulted in: hospitalization

Suspect drug(s):
    Dosage: 1 mg, prn
    Indication: Back Pain

    Dosage: 0.4 mg/hr, unk

    Dosage: 150 mg, see text
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-07-01

Oxycodone HCL
    Dosage: 20 mg, q4h
    Administration route: Oral
    Indication: Back Pain

Oxycodone HCL
    Dosage: 30 mg, q4h
    Administration route: Oral

    Dosage: 160 mg, tid
    Administration route: Oral
    Indication: Back Pain
    Start date: 2010-06-30

    Dosage: 80 mg, see text
    Administration route: Oral
    Start date: 2010-07-01

    Dosage: 60 mg, see text
    Start date: 2010-07-01

See index of all Dilaudid-HP side effect reports >>

Drug label data at the top of this Page last updated: 2007-03-14

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