Dilatrate-SR (Isosorbide Dinitrate) - Summary

DILATRATE-SR SUMMARY

dilatrate® - SR
(isosorbide dinitrate)
sustained release capsules
40 MG
RX ONLY

Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5 dinitrate, an organic nitrate. The organic nitrates are vasodilators, active on both arteries and veins. Each dilatrate®-SR sustained release capsule contains 40 mg of isosorbide dinitrate, in a micro-dialysis delivery system that causes the active drug to be released over an extended period.

dilatrate®-SR sustained release capsules are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of controlled-release oral isosorbide dinitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.

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DILATRATE-SR NEWS HIGHLIGHTS

Published Studies Related to Dilatrate-SR (Isosorbide)

Isosorbide mononitrate versus alendronate for postmenopausal osteoporosis. [2008.09.20]

Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor. [2008.04]

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. [2007.09]

Evidence for the continued safety and tolerability of fixed-dose isosorbide dinitrate/hydralazine in patients with chronic heart failure (the extension to African-American Heart Failure Trial). [2007.08.15]

Nitric oxide donor isosorbide mononitrate for pre-induction cervical ripening at 41 weeks' gestation: A randomized controlled trial. [2007.08]

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Clinical Trials Related to Dilatrate-SR (Isosorbide)

Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients [Recruiting]

Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate [Active, not recruiting]

Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3 [Recruiting]

Secondary Prophylaxis After Variceal Bleeding in Non-Responders [Completed]

Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response [Recruiting]

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