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Dilantin-125 (Phenytoin) - Side Effects and Adverse Reactions



Body As a Whole

Allergic reactions in the form of rash and rarely more serious forms (see Skin and Appendages paragraph below) and DRESS (see WARNINGS) have been observed. Anaphylaxis has also been reported.

There have also been reports of coarsening of facial features, systemic lupus erythematosus, periarteritis nodosa, and immunoglobulin abnormalities.

Nervous System

The most common adverse reactions encountered with phenytoin therapy are nervous system reactions and are usually dose-related. Reactions include nystagmus, ataxia, slurred speech, decreased coordination, somnolence, and mental confusion. Dizziness, vertigo, insomnia, transient nervousness, motor twitchings, paresthesias, and headaches have also been observed. There have also been rare reports of phenytoin-induced dyskinesias, including chorea, dystonia, tremor and asterixis, similar to those induced by phenothiazine and other neuroleptic drugs.

A predominantly sensory peripheral polyneuropathy has been observed in patients receiving long-term phenytoin therapy.

Digestive System

Acute hepatic failure, toxic hepatitis, liver damage, nausea, vomiting, constipation, enlargement of the lips, and gingival hyperplasia.

Skin and Appendages

Dermatological manifestations sometimes accompanied by fever have included scarlatiniform or morbilliform rashes. A morbilliform rash (measles-like) is the most common; other types of dermatitis are seen more rarely. Other more serious forms which may be fatal have included bullous, exfoliative or purpuric dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis (see WARNINGS section). There have also been reports of hypertrichosis.

Hematologic and Lymphatic System

Hematopoietic complications, some fatal, have occasionally been reported in association with administration of phenytoin. These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. While macrocytosis and megaloblastic anemia have occurred, these conditions usually respond to folic acid therapy. Lymphadenopathy including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin's disease have been reported (see WARNINGS section).

Special Senses

Altered taste sensation including metallic taste.


Peyronie's disease


Below is a sample of reports where side effects / adverse reactions may be related to Dilantin-125. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dilantin-125 side effects / adverse reactions in 37 year old male

Reported by a physician from United States on 2011-10-10

Patient: 37 year old male

Reactions: Drug Ineffective, Convulsion

Suspect drug(s):
    Dosage: unk

    Dosage: unk

Possible Dilantin-125 side effects / adverse reactions in 71 year old male

Reported by a consumer/non-health professional from United States on 2011-10-28

Patient: 71 year old male

Reactions: Hypoacusis, Convulsion

Suspect drug(s):

Possible Dilantin-125 side effects / adverse reactions in 73 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-23

Patient: 73 year old female

Reactions: Grand MAL Convulsion, Pyrexia, Muscle Disorder, Convulsion

Suspect drug(s):
    Dosage: unk
    Start date: 1964-01-01

    Dosage: unk
    Indication: Grand MAL Convulsion
    Start date: 1947-01-01

See index of all Dilantin-125 side effect reports >>

Drug label data at the top of this Page last updated: 2014-03-21

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