Media Articles Related to Dilantin-125 (Phenytoin)
Nerve damage in MS could be prevented with epilepsy drug
Source: Clinical Trials / Drug Trials News From Medical News Today [2016.01.26]
An epilepsy drug - phenytoin - reduced nerve damage by 30% in people with optic neuritis, a new study found, bringing us closer to a neuroprotective drug for multiple sclerosis.
Published Studies Related to Dilantin-125 (Phenytoin)
Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized
clinical trial. 
in children with acute coma... CONCLUSION: A single intramuscular injection of fosphenytoin (20 phenytoin
The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial. [2011.10]
AIM: The aim of the study was to evaluate the effect of topical phenytoin on healing in diabetic foot ulcers. A randomized, controlled, double-blind, clinical trial was conducted... CONCLUSIONS: There were no differences in diabetic foot ulcer closure rates or in diabetic foot ulcer area over time between the two groups. This study does not support the use of phenytoin in the treatment of diabetic foot ulcers. (c) 2011 The Authors. Diabetic Medicine (c) 2011 Diabetes UK.
Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers. [2011.07]
PURPOSE: Statins and antiepileptic drugs (AEDs) are frequently coprescribed to individuals with hypercholesterolemia and new-onset seizures...
Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. [2011.04.12]
OBJECTIVE: Gingival overgrowth is an important adverse effect of phenytoin (PHT) therapy, occurring in about half of the patients. This study aimed to evaluate the effect of oral folic acid supplementation (0.5 mg/day) for the prevention of PHT-induced gingival overgrowth (PIGO) in children with epilepsy aged 6-15 years on PHT monotherapy for 6 months... CONCLUSIONS: Oral folic acid was found to decrease the incidence of PIGO in children on PHT monotherapy, in a statistically significant and clinically relevant manner. Classification of evidence: This study provides Class I evidence that folic acid supplementation, 0.5 mg/day, is associated with prevention of gingival overgrowth in children taking PHT monotherapy.
Pregabalin effect on steady-state pharmacokinetics of carbamazepine, lamotrigine, phenobarbital, phenytoin, topiramate, valproate, and tiagabine. [2011.02]
By reducing neuronal excitability through selective binding to the alpha(2)delta subunit of voltage-dependent calcium channels, pregabalin effectively treats epilepsy, chronic pain, and anxiety disorders. To evaluate if pregabalin coadministration affects pharmacokinetics of other antiepileptic drugs, population pharmacokinetic analyses using NONMEM software were performed on data from three epilepsy trials involving seven antiepileptic drugs with pregabalin as add-on therapy...
Clinical Trials Related to Dilantin-125 (Phenytoin)
Phenytoin in the Healing of Clean Surgical Wounds [Recruiting]
The purpose of this study is to investigate the potential healing properties of phenytoin.
The investigators will use the donor site of a split skin thickness graft (SSTG) to model a
basic wound in a randomized controlled trial of topical phenytoin against current best
clinical practice. The investigators aim to demonstrate a dose dependent effect. The
investigators hypothesis, based on previous clinical experience at our center and on current
available literature, that phenytoin will reduce wound healing time.
Phenytoin as a Neuroprotective Agent Against Corticosteroid-induced Functional Imaging Changes [Completed]
The purpose of this research is to determine if patients who receive phenytoin (also
commonly known as Dilantin) before taking corticosteroids will show less memory impairment
and hypomanic symptoms (feelings of agitation, overexcitement or hyperactivity) than those
receiving placebo (an inactive substance). This research also seeks to determine if
patients taking phenytoin before corticosteroids show more activity in the area of the brain
involved with memory than those receiving placebo.
This research is being done because increased levels of cortisol (the body's natural
corticosteroid) in the body are frequently associated with forgetfulness, and interventions
that may prevent or reverse this effect are of great importance.
Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management [Recruiting]
The Investigator plans to perform a prospective, randomized, single blinded, study that will
compare patients treated with IV lacosamide to those treated with Phenytoin in the Intensive
Care Unit (ICU) setting. The investigator will also evaluate the rate of clinically evident
and sub-clinical seizures, and to compare long-term outcomes between patients treated with
lacosamide and those treated with Phenytoin.
A Study to Investigate the Potential Pharmacokinetic Interactions Between Phenytoin or Carbamazepine and Telaprevir [Completed]
The purpose of this study is to investigate the potential pharmacokinetic (what the body
does to the drug) interactions between multiple doses of phenytoin 200 mg every 12 hours or
carbamazepine 200 mg every 12 hours and telaprevir 750 mg every 8 hours at steady-state
(constant concentration of medication in the blood) in healthy participants.
Bioequivalence Study Of Phenytoin Suspension Versus EpaminŽ In 34 Healthy Volunteers. [Completed]
Mexican healthy volunteers will receive the current form of the drug (under the name of
Epamin) as well as Pfizer's compound (Phenytoin). Bioequivalence will be tested.
Reports of Suspected Dilantin-125 (Phenytoin) Side Effects
Stevens-Johnson Syndrome (90),
Drug Hypersensitivity (18),
Drug Ineffective (16),
Grand MAL Convulsion (16),
Anticonvulsant Drug Level Decreased (14),
Drug Level Decreased (10),
Malaise (9), more >>