NEWS HIGHLIGHTS
Published Studies Related to Dilacor XR (Diltiazem)
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. [2009.10]
Objective: To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure...
Effect of diltiazem on kidney function during laparoscopic surgery. [2009.08]
BACKGROUND: Pneumoperitoneum is known to be associated with transient impairment in kidney function. This study was designed to investigate the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery... CONCLUSION: Continuous infusion of diltiazem 2 microg/kg/min prevented the decrease in CrCl during pneumoperitoneum without hemodynamic derangement. Although the decrease in CrCl was transient in patients with normal kidney function in this study, diltiazem may be used to prevent further kidney injury in those with elevated CrCl during laparoscopic surgery.
Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. [2009.07]
OBJECTIVES: To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization... CONCLUSIONS: As compared with digoxin and amiodarone, intravenous diltiazem was safe and effective in achieving VR control to improve symptoms and to reduce hospital stay in patients with acute AF.
Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: a prospective randomized trial. [2009.01]
AIM: To assess the efficacy of internal sphincterotomy compared with application of topical 2% Diltiazem ointment after hemorrhoidectomy for pain relief. SETTINGS AND DESIGN: Prospective randomized study... CONCLUSIONS: In patients undergoing hemorrhoidectomy, addition of surgical internal sphincterotomy results in lesser pain in the postoperative period as compared to those receiving topical application of Diltiazem.
Influence of grape juice and orange juice on the pharmacokinetics and pharmacodynamics of diltiazem in healthy human male subjects. [2008.10]
CONCLUSIONS: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem.
Clinical Trials Related to Dilacor XR (Diltiazem)
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem [Recruiting]
This is a pilot clinical study to assess whether the administration of diltiazem may be able
to decrease the development or progression of hypertrophic cardiomyopathy (HCM). Diltiazem
is a commonly used medication for the treatment of high blood pressure and studies on
animals with HCM suggest that diltiazem decreases disease development. This study
specifically targets individuals in the "prehypertrophic" phase of HCM-- those with
documented sarcomere gene mutations without echocardiographic or EKG evidence of LVH.
The hypothesis of this study is that starting diltiazem administration early in life (in the
prehypertrophic phase) will decrease the progression of HCM in individuals with sarcomere
gene mutations. This will be assessed by looking at an improvement in the heart's ability to
relax using echocardiography.
Verapamil and Catamenial Epilepsy [Not yet recruiting]
One in 3 epilepsy patients have refractory seizures. This drug resistance is likely related
to the over expression of multidrug resistance proteins (MDR). Progesterone is a known
inhibitor of MDRs and the low level of this hormone during the menstrual cycle may
exacerbate seizures, perhaps explaining catamenial epilepsy; i. e. seizures occurring during
the menstrual cycle. Verapamil suppresses seizures in animal models of epilepsy perhaps by
inhibiting MDRs and thus may help patients with refractory seizures. If the study shows
improved seizure control, the results will help establish the role of MDRs in refractory
epilepsy.
Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction [Recruiting]
The purpose of this study is to evaluate the efficacy of three different vasodilators
including diltiazem, verapamil and nitroglycerin for reversal of no-reflow/slow-flow during
direct percutaneous coronary intervention for acute myocardial infarction.
Low Dose of Diltiazem for Rate Control of Atrial Fibrillation [Recruiting]
This study is to show the efficacy and safety of low dose diltiazem for the treatment of
atrial fibrillation with rapid ventricular response in emergency room. We will compare the
standard dose of diltiazem(0. 25mg/kg) with low dose diltiazem(0. 1mg/kg).
Combination of Hydroxyurea and Verapamil for Refractory Meningiomas [Recruiting]
Meningiomas account for 20% of primary adult brain tumors, occurring at an annual incidence
of 6 per 100,000 (Louis, Scheithauer et al. 2000). Complete surgical resection is the
treatment of choice but may not possible when the tumor invades critical structures (e. g.,
skull base, sagittal sinus) (Mirimanoff, Dosoretz et al. 1985; al-Rodhan and Laws 1990;
Al-Rodhan and Laws 1991; Newman 1994; De Monte 1995; Levine, Buchanan et al. 1999; Barnett,
Suh et al. 2000; Ragel and Jensen 2003). Up to 20% of meningiomas exhibit a more aggressive
phenotype that does not respond to standard therapies (Kyritsis 1996). Adjuvant therapies
are critical for patients with this subset of meningiomas. Radiation therapy and
stereotactic radiosurgery are good adjuvant therapies but are limited by radiation
neurotoxicity, tumor size constraints, and injury to adjacent vascular structures or cranial
nerves (Goldsmith, Wara et al. 1994; Barnett, Suh et al. 2000; Goldsmith and Larson 2000).
Standard chemotherapeutic treatments have been disappointing (Kyritsis 1996). Even drugs
like temozolomide that have shown efficacy against malignant brain tumors have failed to
inhibit the growth of refractory meningiomas in a phase II study (Chamberlain, Tsao-Wei et
al. 2004).
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