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Antitussive/Antihistamine/Decongestant
Rx Only
CIII
DESCRIPTION
Each teaspoonful (5 mL) for oral administration contains:
Dihydrocodeine Bitartrate.....................................................7.5 mg
(WARNING-May be habit forming)
Chlorpheniramine Maleate.......................................................2 mg
Pseudoephedrine Hydrochloride.............................................15 mg
This product contains the following inactive ingredients:
Citric Acid, Glycerin, Grape Flavor, Propylene Glycol, Purified Water, Sodium Citrate, Sodium Saccharin, Sorbitol.
Dihydrocodeine Bitartrate is an antitussive with the chemical name (Morphine-6-ol,4,5-epoxy-3-methoxy-17methyl-,(5alpha,6
alpha)-2,3-dihydroxybutanedioate (1:1) (salt). It has the following structural formula:
Chlorpheniramine Maleate is an antihistamine having the chemical name 2-Pyridinepropanamine,
γ-(4-chlorophenyl)-N,N-dimethyl-,(Z)-2-butenedioate (1:1). It has the following chemical structure:
Pseudoephedrine Hydrochloride is a decongestant having the chemical name, Benzenemethanol,
alpha-[1-(methylamino) ethyl]-,[S-(R*R*)-, hydrochloride. It has the following structural formula:
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CLINICAL PHARMACOLOGY
Dihydrocodeine is a semisynthetic narcotic analgesic antitussive related to codeine, with multiple actions qualitatively similar to those of codeine: the most prominent of these involve the central nervous system and organs with smooth muscle components.
Chlorpheniramine is an alkylamine type antihistamine. This group of antihistamines is among the most active histamine antagonists and is generally effective in relatively low doses. The drugs are not so prone to produce drowsiness and are therefore among the most suitable agents for daytime use, but a significant proportion of patients do experience this effect.
Pseudoephedrine Hydrochloride is a sympathomimetic amine, which acts predominately on alpha-receptors and has little action on beta-receptors. It therefore functions as an oral nasal decongestant with minimal CNS stimulation.
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