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Dihydro (Dihydrocodeine Bitartrate / Chlorpheniramine Maleate / Pseudoephedrine Hydrochloride) - Summary

 
 



DIHYDRO SUMMARY

Antitussive/Antihistamine/Decongestant
Rx Only
CIII

This product is indicated for the temporary relief of cough and nasal congestion associated with upper respiratory tract infections and allergies.

See all Dihydro indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Dihydro (Dihydrocodeine / Chlorpheniramine / Pseudoephedrine)

Cold and Cough Medicine for Infants and Children: A Doctor's View
Source: MedicineNet Aches, Pain, Fever Specialty [2016.04.11]
Title: Cold and Cough Medicine for Infants and Children: A Doctor's View
Category: Doctor's & Expert's views on Symptoms
Created: 10/18/2007 12:00:00 AM
Last Editorial Review: 4/11/2016 12:00:00 AM

Children's Cough Causes and Treatments
Source: MedicineNet Allergy Treatment Begins At Home Specialty [2016.03.15]
Title: Children's Cough Causes and Treatments
Category: Diseases and Conditions
Created: 11/19/2012 12:00:00 AM
Last Editorial Review: 3/15/2016 12:00:00 AM

Waning Whooping Cough Immunity Blamed in Outbreaks
Source: MedicineNet Pertussis Specialty [2016.02.05]
Title: Waning Whooping Cough Immunity Blamed in Outbreaks
Category: Health News
Created: 2/5/2016 12:00:00 AM
Last Editorial Review: 2/5/2016 12:00:00 AM

Whooping cough booster vouchers don't boost immunization rates of caregivers
Source: Caregivers / Homecare News From Medical News Today [2016.02.04]
Cases of pertussis (whooping cough) have increased dramatically over the past five years, putting infants at risk of serious illness or death.

Microscopic view of coughed-up mucus may be new biomarker for cystic fibrosis progression
Source: Cystic Fibrosis News From Medical News Today [2015.10.14]
Cystic fibrosis is a disease that causes very thick mucus secretions to build up within the lungs, which in turn, leads to inflammation and chronic lung infections.

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Published Studies Related to Dihydro (Dihydrocodeine / Chlorpheniramine / Pseudoephedrine)

13,14-Dihydro-15-keto prostaglandin F2alpha release in response to oxytocin challenge early post-partum in anoestrous Nelore cows submitted to temporary calf removal and progesterone priming. [2010.10]
The study evaluated, in early post-partum anoestrous Nelore cows, if the increase in plasma oestradiol (E2) concentrations in the pre-ovulatory period and/or progesterone priming (P4 priming) preceding ovulation, induced by hormonal treatment, reduces the endogenous release of prostaglandin PGF(2)alpha and prevents premature lysis of the corpus luteum (CL).

Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2alpha in heifers. [2010.03]
Progesterone and luteal blood flow effects of an i.u. 2-h infusion of 0.25 mg/h of prostaglandin F(2)(alpha) (PGF) that simulated a natural pulse of 13,14-dihydro-15-keto-PGF (PGFM) were compared to the effects of a single bolus i.u... The comparisons between progesterone and blood flow are novel.

An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing. [2009.03]
(R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]-pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxyphenyl)-acetamide (AMG 487) is a potent and selective orally bioavailable chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist that displays dose- and time-dependent pharmacokinetics in human subjects after multiple oral dosing...

Effect of dose of estradiol-17beta on prominence of an induced 13,14-dihydro-15-keto-PGF(2alpha) (PGFM) pulse and relationship of prominence to progesterone, LH, and luteal blood flow in heifers. [2011.08]
Various doses of estradiol-17beta (E(2)) were used in heifers to induce a pulse of 13,14-dihydro-15-keto-prostaglandin F(2alpha) (PGFM). The effect of E(2) concentration on the prominence of PGFM pulses and the relationship between prominence and intrapulse concentration of progesterone (P(4)), LH, and luteal blood flow were studied...

Mixture of cis-3-hexenol and trans-2-hexenal attenuates behavioral and stress responses induced by 2,5-dihydro-2,4,5-trimethylthiazoline and electric footshock stress in rats. [2011.07.06]
Green odor (GO), a mixture of cis-3-hexenol and trans-2-hexenal, attenuates stress responses and anxiety to psychological stressors in rodents; however, it remains unknown whether GO affects behavioral and stress responses to risk-related olfactory stimuli and actual noxious stimuli...

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Clinical Trials Related to Dihydro (Dihydrocodeine / Chlorpheniramine / Pseudoephedrine)

[18F] Dihydro-testosterone Pet and MR Imaging In Patients With Localized Prostate Cancer [Recruiting]
The purpose of this study is to test the ability of a new PET scan radiotracer, called FDHT (stands for [18F] Dihydro-Testosterone), to better find and monitor prostate cancer. Radiotracers are a type of drug that carries small amounts of radioactivity that can be seen by the PET scanner. FDHT is a radiotracer that looks for a protein which is present in almost all prostate cancer cells. The investigators want to find out if we can find and monitor changes in cancer using a FDHT PET scan.

[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer [Recruiting]
This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.

Triciribine Phosphate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer [Recruiting]
This phase I/II trial studies the side effects and the best dose of triciribine phosphate when given together with paclitaxel, doxorubicin hydrochloride, and cyclophosphamide and to see how well they work in treating patients with stage IIB-IV breast cancer. Triciribine phosphate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as paclitaxel, doxorubicin hydrochloride, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving triciribine phosphate with paclitaxel, doxorubicin hydrochloride, and cyclophosphamide may be a better treatment for breast cancer.

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome [Not yet recruiting]
This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Response-based chemotherapy separates patients into different risk groups and treats them according to how they respond to the first course of treatment (Induction I). Response-based treatment may be effective in treating acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome while reducing the side effects.

Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy? [Recruiting]
Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost. A recent randomized controlled trial from the University of Heidelberg showed that consumption of regular black coffee after colectomy is safe and associated with a significantly faster resumption of intestinal motility (Müller 2012). The mechanism how coffee stimulates intestinal motility is unknown but caffeine seems to be the most likely stimulating agent. Thus, this trial addresses the question: Does caffeine reduce postoperative bowel paralysis after elective laparoscopic colectomy? Patients after laparoscopic colectomy will receive either 100 mg caffeine, 200 mg caffeine, or 250mg corn starch (placebo) 3 times daily in identically looking gelatin capsules. The study is a randomized, controlled trial, with blinding of physicians, patients and nursing stuff (evaluating the endpoints). Primary endpoint will be the time to first bowel movement.

more trials >>


Page last updated: 2016-04-11

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