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Diflucan (Fluconazole) - Summary

 
 



DIFLUCAN SUMMARY

DIFLUCAN® (fluconazole), the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration, as a powder for oral suspension, and as a sterile solution for intravenous use in glass and in Viaflex® Plus plastic containers.

DIFLUCAN (fluconazole) is indicated for the treatment of:

  1. Vaginal candidiasis (vaginal yeast infections due to Candida).
  2. Oropharyngeal and esophageal candidiasis. In open noncomparative studies of relatively small numbers of patients, DIFLUCAN was also effective for the treatment of Candida urinary tract infections, peritonitis, and systemic Candida infections including candidemia, disseminated candidiasis, and pneumonia.
  3. Cryptococcal meningitis. Before prescribing DIFLUCAN (fluconazole) for AIDS patients with cryptococcal meningitis, please see CLINICAL STUDIES section. Studies comparing DIFLUCAN to amphotericin B in non-HIV infected patients have not been conducted.

Prophylaxis. DIFLUCAN is also indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy.

Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained prior to therapy to isolate and identify causative organisms. Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly.


See all Diflucan indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Diflucan (Fluconazole)

Fluconazole prophylaxis in extremely low birth weight infants and neurodevelopmental outcomes and quality of life at 8 to 10 years of age. [2011.05]
OBJECTIVE: To examine the long-term effects of fluconazole prophylaxis in extremely low birth weight infants... CONCLUSIONS: Fluconazole prophylaxis for the prevention of invasive Candida infections is safe in extremely low birth weight infants and does not appear to be associated with any long-term adverse effects on neurodevelopment and quality of life at 8 to 10 years of life. Copyright (c) 2011 Mosby, Inc. All rights reserved.

Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants. [2011.05]
BACKGROUND: Invasive fungal infections are a major cause of morbidity and mortality in preterm infants. The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates... CONCLUSIONS: Prophylactic nystatin and fluconazole reduce the incidence of colonisation and invasive fungal infection in VLBW neonates. The authors believe that nystatin is an alternative to fluconazole, because nystatin is safe, inexpensive, well tolerated and effective.

A pseudo-randomised clinical trial of in situ gels of fluconazole for the treatment of oropharngeal candidiasis. [2011.04.19]
CONCLUSIONS: The in situ gel formulation of fluconazole was well tolerated with no severe adverse reaction and offers a better alternative to tablet formulation in the treatment of oropharyngeal candidasis. TRIAL REGISTRATION: Current Controlled Trails ISRCTN90634047.

Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. [2011.04]
Comparative pharmacokinetics of vitamin K epoxide reductase antagonists tecarfarin and warfarin were assessed before and after coadministration for 21 days of the CYP450 inhibitor fluconazole in a randomized, open-label, single-center drug interaction study... In contrast, tecarfarin pharmacokinetics were apparently unchanged by fluconazole.

Anidulafungin compared with fluconazole for treatment of candidemia and other forms of invasive candidiasis caused by Candida albicans: a multivariate analysis of factors associated with improved outcome. [2011]
contributed to the treatment differences... CONCLUSIONS: In patients with C. albicans infection, anidulafungin was more

more studies >>

Clinical Trials Related to Diflucan (Fluconazole)

Bioavailability Study of Fluconazole Tablets 200 mg Under Fed Conditions [Completed]
The objective of this study was an open-label, randomized, 2-way crossover to compare the single-dose relative bioavailability of Dr. Reddy's Laboratories, Ltd. and Pfizer (Diflucan«) 200 mg fluconazole tablets under fed conditions.

Bioavailability Study of Fluconazole Tablets 200 mg Under Fasting Conditions [Completed]
The objective of this study was an open-label, randomized, 2-way crossover to compare the single-dose relative bioavailability of Dr. Reddy's Laboratories, Ltd. and Pfizer (Diflucan«) 200 mg fluconazole tablets under fasting conditions.

Pharmacokinetics (PK) Study of a Fluconazole Loading Dose in Infants and Toddlers [Completed]

Diflucan Research For Infant Evaluation Of Antifungal Treatment And Prophylaxis Medication [Completed]

Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection [Terminated]
The purpose of this study is to determine if treatment with two medicines in combination (fluconazole and flucytosine) is safe as compared with one medicine alone (fluconazole) for the treatment of an early infection with a fungus called cryptococcus.

more trials >>

Reports of Suspected Diflucan (Fluconazole) Side Effects

Hyperkalaemia (10)Drug Interaction (10)Renal Disorder (10)Drug Ineffective (9)Interstitial Lung Disease (8)Nausea (8)Renal Impairment (7)Fall (6)Death (6)Blood Pressure Decreased (6)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Diflucan has an overall score of 5.75. The effectiveness score is 7 and the side effect score is 8.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Diflucan review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   vaginal yeast infection
Dosage & duration:   1 tablet taken once for the period of once
Other conditions:   none
Other drugs taken:   Difflucan cream
  
Reported Results
Benefits:   the infection vanished after 2 days, I had already tried canesten cream and that did not help cure the infection fully.
Side effects:   none I could see, the infection vanished after 2 days and did not come back. i don't know if there are any side effects by taking the tablet you may wish to look in to it further.
Comments:   One tablet and then cream twice a day for a week. The tablet was taken once only. I used the cream a few more times during the day in the beginning of the treatment when I needed it.

 

Diflucan review by 17 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Candida caused yeast infection
Dosage & duration:   150 (dosage frequency: 1 time) for the period of 1 day
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   The yeast stopped coming out in chunks, but was more watery like... Still yeast tho so I wasn't pleased...
Side effects:   Didn't have any side effects
Comments:   I had sex the day after I took the pill with my only partner. I had sex wit him with the yeast infection before I took the pill so if I gave it to him, he probably gave it back to me :( the doc gave me a pill for him and for me. He took his after we had sex. Which was the day after I took mine... Is this y I still hav it? I thought it took days to work that's y I had sex

 

Diflucan review by 17 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Candida caused yeast infection
Dosage & duration:   150 (dosage frequency: 1 time) for the period of 1 day
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   The yeast stopped coming out in chunks, but was more watery like... Still yeast tho so I wasn't pleased...
Side effects:   Didn't have any side effects
Comments:   I had sex the day after I took the pill with my only partner. I had sex wit him with the yeast infection before I took the pill so if I gave it to him, he probably gave it back to me :( the doc gave me a pill for him and for me. He took his after we had sex. Which was the day after I took mine... Is this y I still hav it? I thought it took days to work that's y I had sex

See all Diflucan reviews / ratings >>

Page last updated: 2013-02-10

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