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Differin (Adapalene) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used DIFFERIN® Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with DIFFERIN® Cream from the controlled clinical studies is provided in the following table:

Incidence of Local Cutaneous Irritation with DIFFERIN® Cream from Controlled Clinical Studies (N=285)
  None Mild Moderate Severe

Erythema

52% (148) 38% (108) 10% (28) <1% (1)

Scaling

58% (166) 35% (100) 6% (18) <1% (1)
Dryness 48% (136) 42% (121) 9% (26) <1% (2)
Pruritus  (persistent) 74% (211) 21% (61) 4% (12) <1% (1)
Burning/Stinging (persistent) 71% (202) 24% (69) 4% (12) <1% (2)

Other reported local cutaneous adverse events in patients who used DIFFERIN® Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with DIFFERIN® Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.



REPORTS OF SUSPECTED DIFFERIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Differin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Differin side effects / adverse reactions in 48 year old female

Reported by a consumer/non-health professional from United States on 2011-10-26

Patient: 48 year old female

Reactions: Burning Sensation, Pruritus, Eye Swelling, Rash, Erythema

Suspect drug(s):
Differin
    Administration route: Topical
    Indication: Acne Cystic
    Start date: 2011-07-14
    End date: 2011-07-14

Doxycycline
    Indication: Acne Cystic
    Start date: 2011-07-07



Possible Differin side effects / adverse reactions in 48 year old female

Reported by a consumer/non-health professional from United States on 2011-12-13

Patient: 48 year old female

Reactions: Burning Sensation, Pruritus, Eye Swelling, Rash, Erythema

Suspect drug(s):
Differin
    Administration route: Topical
    Indication: Acne Cystic
    Start date: 2011-07-14
    End date: 2011-07-14

Doxycycline
    Indication: Acne Cystic
    Start date: 2011-07-07



Possible Differin side effects / adverse reactions in 14 year old female

Reported by a consumer/non-health professional from United States on 2012-02-17

Patient: 14 year old female

Reactions: Burns Second Degree, Burns Third Degree, Skin Irritation, Blister

Suspect drug(s):
Differin



See index of all Differin side effect reports >>

Drug label data at the top of this Page last updated: 2009-11-23

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