DIFFERIN SUMMARY
DIFFERIN®
(adapalene gel)
Gel, 0.1%
Rx Only
Differin® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of Differin® Gel contains adapalene 0.1% (1mg) in a vehicle consisting of propylene glycol, carbomer 940, poloxamer 182, edetate disodium, methylparaben, sodium hydroxide, and purified water. May contain hydrochloric acid to adjust pH.
Differin® Gel is indicated for the topical treatment of acne vulgaris.
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NEWS HIGHLIGHTSMedia Articles Related to Differin (Adapalene)
Scientists Map Origin Of MRSA, Technology Could Help Understanding Of Other Diseases
Source: MRSA / Drug Resistance News From Medical News Today [2010.01.25]
"Scientists have found a way to track minutely-differing strains of the 'superbug' MRSA [methicillin-resistant Staphylococcus aureus] as they spread between people and across the globe, a finding that could aid efforts to control the deadly bacteria," Reuters/ABC News reports (Kelland, 1/21)...
Health Tip: Caring for Acne-Prone Skin (HealthDay)
Source: Y! Health Skin Conditions News [2010.01.21]
HealthDay - (HealthDay News) -- The exact cause of acne isn't understood,
but the American Academy of Dermatology says four factors are involved:
too much oil, clogged pores, bacteria, and inflammation.
Clear Skin Pictures Slideshow: Helping Your Teen With Acne
Source: MedicineNet Acne Specialty [2010.01.21]
Title: Clear Skin Pictures Slideshow: Helping Your Teen With Acne
Category: Slideshows
Created: 1/20/2010 3:54:00 PM
Last Editorial Review: 1/21/2010
Health Tip: Caring for Acne-Prone Skin
Source: MedicineNet Acne Specialty [2010.01.21]
Title: Health Tip: Caring for Acne-Prone Skin
Category: Health News
Created: 1/21/2010 8:10:00 AM
Last Editorial Review: 1/21/2010
Health Tip: What's Triggering My Acne?
Source: MedicineNet Acne Specialty [2009.06.24]
Title: Health Tip: What's Triggering My Acne?
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
Published Studies Related to Differin (Adapalene)
A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne. [2009.08]
A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% recently has been developed for the treatment of acne vulgaris. In this multicenter, randomized, double-blind, parallel-group, active- and vehicle-controlled study conducted at 60 centers in the United States, Puerto Rico, and Canada, we assessed the efficacy and safety of adapalene-BPO combination gel in comparison with adapalene and BPO monotherapies as well as the gel vehicle...
Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. [2009.05.21]
Summary Background Combination therapy utilizing agents with complementary mechanisms of action is recommended by acne guidelines to help simultaneously target multiple pathogenic factors. A unique, topical, fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has recently been developed for the once-daily treatment of acne...
Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. [2009.04]
CONCLUSION: CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.
Prospective, open-label, comparative study of clindamycin 1%/benzoyl peroxide 5% gel with adapalene 0.1% gel in Asian acne patients: efficacy and tolerability. [2009.03]
BACKGROUND: Used as individual agents, topical antibiotics and benzoyl peroxide are known to be effective in treatment of acne. Clindamycin phosphate 1% with benzoyl peroxide 5% (CDP/BPO) is a new combination gel, made by rationale, in that combination drug is more effective than either ingredients used alone. Adapalene 0.1% (ADA) is the third-generation retinoid, shown to be as effective as other topical retinoid with well tolerability. OBJECTIVES: To compare the efficacy and tolerability in combination of CDP/BPO in comparison with ADA in Asian patients with mild to moderate acne vulgaris... CONCLUSION: Combination formulation of CDP/BPO and ADA were shown to be both effective in decreasing total, inflammatory, and non-inflammatory lesion counts along with well tolerability in Asian patients with mild to moderate acne vulgaris.
Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy. [2008.09]
International guidelines recommend the combination of retinoids (e.g... This study showed that adapalene/BPO as a fixed-dose combination is as well tolerated as BPO 2.5% gel alone or adapalene 0.1% gel alone in terms of cumulative irritancy.*Epiduo, Galderma S.A.
Clinical Trials Related to Differin (Adapalene)
Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne [Completed]
To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0. 1%
compared to 12 weeks of treatment with Tazorac Cream, 0. 1% and compared to 6 weeks treatment
with Differin Gel, 0. 1% followed by 6 weeks of treatment with Tazorac Cream
Analysis of Adherence in Subjects Undergoing Differin Gel, 0.1% Treatment of Moderate to Severe Acne Vulgaris [Active, not recruiting]
The purpose of this research study is to see how well the drug works for subjects who have
acne. Adapalene 0. 1% (Differin) will be used in this study to treat your acne. Differin is
approved by the Food and Drug Administration (FDA) to treat acne.
Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris [Completed]
This is a multi-center, randomized, double-blind, parallel group study with 12 weeks of
treatment of acne vulgaris. Efficacy and safety evaluations will be performed at Screening
(safety only), Baseline and Weeks 1, 2, 4, 8 and 12. All Investigator's Global Assessment
evaluators and lesion counters must be trained and approved by Galderma. The evaluator of a
subject should remain the same during the study.
The primary objective is to demonstrate the superiority in efficacy and assess safety of
adapalene/benzoyl peroxide topical gel (adapalene/benzoyl peroxide gel) versus adapalene
topical gel, 0. 1% (adapalene monad); benzoyl peroxide topical gel, 2. 5% (benzoyl peroxide
monad) and topical gel vehicle (gel vehicle) in the treatment of acne vulgaris for up to 12
weeks.
A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris [Completed]
This is a multi-center, randomized, double-blind, parallel group study with 12 weeks of
treatment of acne vulgaris. Efficacy and safety evaluations will be performed at Screening
(safety only), Baseline and Weeks 1, 2, 4, 8 and 12. All Investigator's Global Assessment
evaluators and lesion counters must be trained and approved by Galderma. The evaluator of a
subject should remain the same during the study.
The primary objective is to demonstrate the superiority in efficacy and assess safety of
Adapalene/Benzoyl Peroxide Topical Gel (Adapalene/Benzoyl Peroxide Gel) versus Adapalene
Topical Gel, 0. 1% (Adapalene Monad); Benzoyl Peroxide Topical Gel, 2. 5% (Benzoyl Peroxide
Monad) and Topical Gel Vehicle (Gel Vehicle) in the treatment of acne vulgaris for up to 12
weeks.
Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1% [Recruiting]
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 27 ratings/reviews, Differin has an overall score of 6.96. The effectiveness score is 6.89 and the side effect score is 8.07. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Differin review by 37 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | gel .3% (dosage frequency: 2 times a day) for the period of 4 weeks |
| Other conditions: | | enlarged pores |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The pimples become dry. At first there was formation of new pimples, but then pimples started gradually go away; overall the skin started looking healthier and cleaner. |
| Side effects: | | some bearable feeling of heat/burning |
| Comments: | | applied the gel in the morning and at night on nose, cheeks, forehead, and chin. |
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| | Differin review by 42 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | .3% (dosage frequency: daily) for the period of 3 months |
| Other conditions: | | no other conditions |
| Other drugs taken: | | Persa Gel | | |
Reported Results |
| Benefits: | | Differin does help reduce the number of pimples for an acne patient. It did not eliminate them in my case, but reduced them by about 50%. |
| Side effects: | | Dryness and flakiness were the two most common side effects that I experienced. In addition, my skin became more sensitive to environmental stresses like wind, cold, and sun. Consequently my face often appeared flush. |
| Comments: | | I used a non-soap cleanser to wash my face twice daily. In the morning, I followed this with an application of Persa Gel and then a sunscreen. In the evening after washing my face, I would apply a moisturizer, then the Differin, and then spot treated pimples with Persa Gel. |
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| | Differin review by 24 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | daily (dosage frequency: daily) for the period of three months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | There were little to no benefits to using differin to treat acne. while it may have helped exfoliation, it did little to treat current and to prevent future acne. instead of differin, using a separate skin exfoliation product in addition to an over the counter acne treatment might have been more beneficial. My acne worsened using Differin -- some say it is because the impurities are being purged from beneath the outer layers of the skin. I don't know if I completely buy this theory though I would have believed it if it showed some improvement after three months. Unfortunately, it did not. |
| Side effects: | | There were no side effects to the treatment except that it worsened my breakouts. However, it did nothing to take down the flares even after three months of treatment. Soon after I stopped using it, my skin improved. So now, I choose to use an exfoliation product and a separate over the counter acne treatment product. |
| Comments: | | differin did not help prevent acne or get rid of current acne. it worsened the condition though it was explained that as it helped the skin exfoliate, the impurities beneath the outer skin surfaced. however, there were no improvements after three months of application. |
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Page last updated: 2010-01-25
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