Differin® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of Differin® Gel contains adapalene 0.1% (1mg) in a vehicle consisting of propylene glycol, carbomer 940, poloxamer 182, edetate disodium, methylparaben, sodium hydroxide, and purified water. May contain hydrochloric acid to adjust pH.
Differin® Gel is indicated for the topical treatment of acne vulgaris.
Media Articles Related to Differin (Adapalene)
Pairing school and home programs most effective in fight against teen prescription drug abuse
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.02.20]
Programs that aim to curb teen prescription drug abuse have vastly differing effectiveness, ranging from big drops in drug abuse to no measurable effect, according to a new study of 11,000 teenagers by researchers at Duke and Pennsylvania State universities.
Surprising link discovered between chloracne and a molecule that protects cells against stress
Source: Dermatology News From Medical News Today [2014.02.10]
ETH-Zurich researchers have discovered a new, surprising link between chloracne and a molecule that protects cells against stress: if Nrf2 gets out of control, disfiguring cysts form on the skin.The images were seen all over the world and stuck in the minds of many: in the autumn of 2004, former President of the Ukraine, Viktor Yushchenko, was poisoned with a high dose of dioxin.
Treating autoimmune and transplant patients with the vitamin a used in acne medicines
Source: Transplants / Organ Donations News From Medical News Today [2014.02.03]
The same form of Vitamin A used by teenagers to combat acne might offer benefits that are more than skin deep. That's because an international team of researchers have found that it may also help keep the immune system under control for people with autoimmune disorders or those who have received transplants. This finding was published in the February 2014 issue of the Journal of Leukocyte Biology.
Health Tip: Taming Acne
Source: MedicineNet Acne Specialty [2014.01.10]
Title: Health Tip: Taming Acne
Category: Health News
Created: 1/10/2014 7:35:00 AM
Last Editorial Review: 1/10/2014 12:00:00 AM
Acne Pictures Slideshow: Causes, Solutions and Treatments for Adults
Source: MedicineNet Acne Specialty [2013.11.21]
Title: Acne Pictures Slideshow: Causes, Solutions and Treatments for Adults
Created: 9/15/2011 3:45:00 PM
Last Editorial Review: 11/21/2013 12:00:00 AM
Published Studies Related to Differin (Adapalene)
Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study. [2011.08]
BACKGROUND: Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris. OBJECTIVES: To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris... CONCLUSION: These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. [2011.06]
BACKGROUND: Acne vulgaris is a chronic and frequently recurring disease. A fixed-dose adapalene-benzoyl peroxide (adapalene-BPO) gel is an efficacious and safe acne treatment. OBJECTIVES: To assess the long-term effect of adapalene-BPO on relapse prevention among patients with severe acne after successful initial treatments... CONCLUSIONS: Adapalene-BPO not only prevents the occurrence of relapse among patients with severe acne, but also continues to reduce disease symptoms during 6 months. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists.
The efficacy of adapalene-benzoyl peroxide combination increases with number of
acne lesions. 
vehicle varies with baseline lesion counts... CONCLUSION: The relative benefit of adapalene-BPO increases with higher lesion
Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel. [2010.08]
This single-center, investigator-blinded, randomized, split-face, phase 4 study compared the irritation potential of tretinoin gel microsphere (TGM) 0.04% in a pump dispenser with adapalene 0.1% plus benzoyl peroxide 2.5% gel (ADA-BPO 0.1%/2.5%) in a panel of 170 subjects... While both agents were well tolerated by most patients, TGM 0.04% pump demonstrated significantly better tolerance than ADA-BPO 0.1%/2.5% gel in both neurosensory parameters and signs of contact irritation.
Adapalene 0.1% lotion in the treatment of acne vulgaris: results from two placebo-controlled, multicenter, randomized double-blind, clinical studies. [2010.06]
BACKGROUND: Acne vulgaris is a common chronic skin disease affecting roughly 15 percent of the general population and up to 85 percent of adolescents and young adults. Adapalene, a synthetic naphthoic acid derivative with retinoid activity, has demonstrated good clinical efficacy in the treatment of acne if used with full compliance. OBJECTIVES: To evaluate the efficacy and assess safety of a new adapalene formulation, adapalene 0.1% lotion, versus the lotion vehicle in subjects with acne vulgaris... CONCLUSION: Adapalene 0.1% lotion used once a day for 12 weeks is effective and well tolerated in the treatment of acne vulgaris.
Clinical Trials Related to Differin (Adapalene)
Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne [Completed]
To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0. 1%
compared to 12 weeks of treatment with Tazorac Cream, 0. 1% and compared to 6 weeks treatment
with Differin Gel, 0. 1% followed by 6 weeks of treatment with Tazorac Cream
Analysis of Adherence in Subjects Undergoing Differin Gel, 0.1% Treatment of Moderate to Severe Acne Vulgaris [Active, not recruiting]
The purpose of this research study is to see how well the drug works for subjects who have
acne. Adapalene 0. 1% (Differin) will be used in this study to treat your acne. Differin is
approved by the Food and Drug Administration (FDA) to treat acne.
A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging [Recruiting]
The purpose of this study is to:
1. Evaluate the efficacy of Adapalene gel 0. 3% compared to Tretinoin Emollient cream
0. 05%, reducing signs of cutaneous photoageing, measured trough photonumeric scale
evaluation, investigator evaluation of global response to treatment and subject's
evaluation of improvement.
2. Evaluate the safety and tolerability of Adapalene Gel 0. 3%, compared to Tretinoin
Emollient cream 0. 05% during 24 weeks of treatment.
The study has the clinical hypothesis that Adapalene Gel 0. 3% is as effective as Tretinoin
Emollient cream 0. 05% in the treatment of cutaneous photoaging.
Pharmacokinetics Study of Dapsone-Adapalene Fixed Combination Gel in Acne [Not yet recruiting]
This study will investigate the pharmacokinetics, safety and tolerability of dapsone and
adapalene following topical administration of 2 formulations of dapsone/adapalene fixed
combination gel, dapsone 5% gel (ACZONE®), and adapalene 0. 3% gel (Differin®) in subjects
with acne vulgaris.
A Pilot Study to Evaluate The Efficacy of Adapalene 0.3% for Use in the Prevention and Treatment of Senile Purpura [Recruiting]
This is an open label 6 month pilot study for male and female participants over the age of
52 that desire treatment and prevention of senile purpura of the forearms.
This study will be evaluating the effects of Adapalene 0. 3% for the use in the treatment and
prevention of senile purpura.
Reports of Suspected Differin (Adapalene) Side Effects
Skin Irritation (4),
Burning Sensation (3),
Burns Second Degree (3),
Burns Third Degree (2),
Facial Pain (2),
Eye Swelling (2), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 38 ratings/reviews, Differin has an overall score of 6.89. The effectiveness score is 6.84 and the side effect score is 7.95. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Differin review by 37 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Considerably Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Acne|
|Dosage & duration:|| || gel .3% (dosage frequency: 2 times a day) for the period of 4 weeks|
|Other conditions:|| || enlarged pores|
|Other drugs taken:|| || none|
|Benefits:|| || The pimples become dry. At first there was formation of new pimples, but then pimples started gradually go away; overall the skin started looking healthier and cleaner. |
|Side effects:|| || some bearable feeling of heat/burning |
|Comments:|| || applied the gel in the morning and at night on nose, cheeks, forehead, and chin. |
Differin review by 22 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Acne problem|
|Dosage & duration:|| || Apply it all over the face (dosage frequency: every night) for the period of 2 months|
|Other conditions:|| || Pits and blemishes over the skin.|
|Other drugs taken:|| || Azee|
|Benefits:|| || Texture of the skin has improved a lot by regularly going for peel sessions and by using the prescribed drugs which has to be used through out the treatment period.|
|Side effects:|| || The negative side is controlling acne during the treatment period is little tough as new skin appears , so one has to keep his face clean by having lots of water and constantly washing the face with the face wash solution prescribed.|
|Comments:|| || The treatment is to improve the skin texture,complexion by constantly going for peels and derma-rollers once in 15days.The above mentioned medicine is prescribed to be used through out the treatment period.|
Differin review by 24 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || acne|
|Dosage & duration:|| || daily (dosage frequency: daily) for the period of three months|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || There were little to no benefits to using differin to treat acne. while it may have helped exfoliation, it did little to treat current and to prevent future acne. instead of differin, using a separate skin exfoliation product in addition to an over the counter acne treatment might have been more beneficial. My acne worsened using Differin -- some say it is because the impurities are being purged from beneath the outer layers of the skin. I don't know if I completely buy this theory though I would have believed it if it showed some improvement after three months. Unfortunately, it did not.|
|Side effects:|| || There were no side effects to the treatment except that it worsened my breakouts. However, it did nothing to take down the flares even after three months of treatment. Soon after I stopped using it, my skin improved. So now, I choose to use an exfoliation product and a separate over the counter acne treatment product.|
|Comments:|| || differin did not help prevent acne or get rid of current acne. it worsened the condition though it was explained that as it helped the skin exfoliate, the impurities beneath the outer skin surfaced. however, there were no improvements after three months of application.|
Page last updated: 2014-02-20