DIFFERIN SUMMARY
Differin® Gel, containing adapalene, is used for the topical treatment of acne vulgaris. Each gram of Differin® Gel contains adapalene 0.1% (1mg) in a vehicle consisting of propylene glycol, carbomer 940, poloxamer 182, edetate disodium, methylparaben, sodium hydroxide, and purified water. May contain hydrochloric acid to adjust pH.
Differin® Gel is indicated for the topical treatment of acne vulgaris.
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DIFFERIN NEWS HIGHLIGHTS Media Articles Related to Differin (Adapalene)
Sleuths Follow Lung Stem Cells For Generations To Shed Light On Healing
Source: Lung Cancer News From Medical News Today [2009.06.05]
More than one kind of stem cell is required to support the upkeep and repair of the lungs, according to a new study published in the journal Cell Stem Cell. Scientists at Duke University Medical Center painstakingly followed and counted genetically labeled cells in the mouse lung for over a year, under differing conditions, to learn more about natural renewal and healing processes.
Roche stops selling acne drug Accutane (Reuters)
Source: Y! Health Skin Conditions News [2009.06.26]
Reuters - Swiss drugmaker Roche Holding AG is no longer selling its acne drug Accutane as it has reached the end of its life cycle and is losing ground to generic alternatives, the company said on Friday.
Health Tip: What's Triggering My Acne?
Source: MedicineNet Acne Specialty [2009.06.24]
Title: Health Tip: What's Triggering My Acne?
Category: Health News
Created: 6/24/2009 7:00:00 AM
Last Editorial Review: 6/24/2009
Local Researcher Shows Botox Clears Up Acne!
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.06.23]
The muscle relaxer Botox has now been shown to positively affect the skin as well. "Botox definitely clears up acne," says Anil Shah M.D. The Chicago plastic surgeon is one of the only doctors worldwide using Botox in an entirely new way. He injects the muscle relaxer directly into the skin to eliminate large pores, oil production, and acne breakouts. Acne is caused when the skin's sebaceous glands release too much oil, or sebum, into the skin's pores.
Health Tip: What's Triggering My Acne? (HealthDay)
Source: Y! Health Skin Conditions News [2009.06.23]
HealthDay - (HealthDay News) -- Acne occurs when skin lesions -- commonly
called pimples -- develop because the skin's oil glands overproduce and
clog the skin's pores.
Published Studies Related to Differin (Adapalene)
Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy. [2008.09]
International guidelines recommend the combination of retinoids (e.g... This study showed that adapalene [generic for Differin]/BPO as a fixed-dose combination is as well tolerated as BPO 2.5% gel alone or adapalene 0.1% gel alone in terms of cumulative irritancy.*Epiduo, Galderma S.A.
Long-term safety and efficacy study of adapalene 0.3% gel. [2008.06]
The efficacy and safety of adapalene [generic for Differin] 0.1% gel in the treatment of acne vulgaris has been demonstrated in multiple controlled clinical trials... Adapalene 0.3% gel was safe and effective in the long-term (up to 1 year) treatment of subjects with acne vulgaris.
Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. [2007.11]
BACKGROUND: A fixed-dose combination gel with adapalene [generic for Differin] 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of adapalene 0.1% -BPO 2.5% fixed combination gel (adapalene-BPO) for the treatment of acne... CONCLUSIONS: The fixed-dose combination of adapalene and BPO provides significantly greater efficacy for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene.
Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study. [2007.07.24]
BACKGROUND: A fixed-dose combination gel with adapalene [generic for Differin] 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne. OBJECTIVE: To evaluate the efficacy and safety of adapalene 0.1% -BPO 2.5% fixed combination gel (adapalene-BPO) for the treatment of acne... CONCLUSIONS: The fixed-dose combination of adapalene and BPO provides significantly greater efficacy for the treatment of acne vulgaris as early as week 1 relative to monotherapies, with a comparable safety profile to adapalene.
Community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne. [2007.07]
Acne is characterized by different types of lesions at different stages of development... This study investigated the efficacy and safety of combination therapy with clindamycin 1%-BPO 5% topical gel plus tretinoin microsphere (RAM) gel 0.04% or 0.1% or adapalene [generic for Differin] (AP) gel 0.1% in moderate to severe acne.
Clinical Trials Related to Differin (Adapalene)
Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne [Completed]
To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0. 1%
compared to 12 weeks of treatment with Tazorac Cream, 0. 1% and compared to 6 weeks treatment
with Differin Gel, 0. 1% followed by 6 weeks of treatment with Tazorac Cream
Analysis of Adherence in Subjects Undergoing Differin Gel, 0.1% Treatment of Moderate to Severe Acne Vulgaris [Active, not recruiting]
The purpose of this research study is to see how well the drug works for subjects who have
acne. Adapalene 0. 1% (Differin) will be used in this study to treat your acne. Differin is
approved by the Food and Drug Administration (FDA) to treat acne.
Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris [Completed]
This is a multi-center, randomized, double-blind, parallel group study with 12 weeks of
treatment of acne vulgaris. Efficacy and safety evaluations will be performed at Screening
(safety only), Baseline and Weeks 1, 2, 4, 8 and 12. All Investigator's Global Assessment
evaluators and lesion counters must be trained and approved by Galderma. The evaluator of a
subject should remain the same during the study.
The primary objective is to demonstrate the superiority in efficacy and assess safety of
adapalene/benzoyl peroxide topical gel (adapalene/benzoyl peroxide gel) versus adapalene
topical gel, 0. 1% (adapalene monad); benzoyl peroxide topical gel, 2. 5% (benzoyl peroxide
monad) and topical gel vehicle (gel vehicle) in the treatment of acne vulgaris for up to 12
weeks.
A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris [Completed]
This is a multi-center, randomized, double-blind, parallel group study with 12 weeks of
treatment of acne vulgaris. Efficacy and safety evaluations will be performed at Screening
(safety only), Baseline and Weeks 1, 2, 4, 8 and 12. All Investigator's Global Assessment
evaluators and lesion counters must be trained and approved by Galderma. The evaluator of a
subject should remain the same during the study.
The primary objective is to demonstrate the superiority in efficacy and assess safety of
Adapalene/Benzoyl Peroxide Topical Gel (Adapalene/Benzoyl Peroxide Gel) versus Adapalene
Topical Gel, 0. 1% (Adapalene Monad); Benzoyl Peroxide Topical Gel, 2. 5% (Benzoyl Peroxide
Monad) and Topical Gel Vehicle (Gel Vehicle) in the treatment of acne vulgaris for up to 12
weeks.
Pharmacokinetic Study to Compare the Systemic Exposure of Differin® Gel, 0.3% or Differin® Gel, 0.1% [Recruiting]
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DIFFERIN PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 23 ratings/reviews, Differin has an overall score of 7.04. The effectiveness score is 6.96 and the side effect score is 8.09. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Differin review by 19 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | 0.1% (dosage frequency: nightly) for the period of 15 weeks |
| Other conditions: | | none |
| Other drugs taken: | | Minocycline | | |
Reported Results |
| Benefits: | | Dramatic reduction in papules and pustules. |
| Side effects: | | Some redness and slight dryness was perceived. Nosystemic side effects were noted, as adapalene is not very well absorbed by the body |
| Comments: | | Application nightly after washing. The first 2 weeks were unpleasant as irritation and breakouts where the most severe, after 4 weeks significant improvement was noted, optimal effectiveness being achieved by the 10th week. |
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| | Differin review by 27 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | .3 mg taken every night for the period of from 2007-present |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I have had acne since the age of fifteen (15). I tried several treatments, but the one that has shown improvement to my skin has been Differin. With Differin, there has been a reduction of blemishes, my skin feels and looks smoother, and the hyperpigmention of my skin has lightened significantly. |
| Side effects: | | Side effects included dryness and irritation of the skin, which were both in part, very mild. |
| Comments: | | apply a thin layer every night to clean skin. |
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| | Differin review by 36 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.1% (dosage frequency: once daily) for the period of once daily / one month |
| Other conditions: | | none |
| Other drugs taken: | | no other drugs | | |
Reported Results |
| Benefits: | | Benefits were intended to be no facial acne |
| Side effects: | | There were no side effects noticed |
| Comments: | | Was to be applied externally to the affected area every night at bedtime afer washing. |
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Page last updated: 2009-06-26
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