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Dicloxacillin (Dicloxacillin Sodium) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Hypersensitive Reactions

The reported incidence of allergic reactions to penicillin ranges from 0.7 to 10 percent (see WARNINGS). Sensitization is usually the result of treatment but some individuals have had immediate reactions to penicillin when first treated. In such cases, it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk and vaccines.

Two types of allergic reactions to penicillin are noted clinically, immediate and delayed.

Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death. Such immediate anaphylactic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus, and fever. Although laryngeal edema, laryngospasm, and hypotension occasionally occur, fatality is uncommon.

Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as 2 to 4 weeks after initiation of therapy. Manifestations of this type of reaction include serum sickness-like symptoms (ie, fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes.

Gastrointestinal Reactions

Nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy.

Pseudomembranous colitis has been reported with the use of dicloxacillin. Therefore, it is important to consider its diagnosis in patients who develop diarrhea in association with dicloxacillin use.

Rare reports have been received during postmarketing surveillance of esophageal burning, esophagitis, and esophageal ulceration, particularly after ingestion of dicloxacillin capsules with an insufficient quantity of water and/or before going to bed (see PRECAUTIONS and DOSAGE AND ADMINISTRATION).

Nervous System Reactions

Neurotoxic reactions similar to those observed with penicillin G (e.g., lethargy, confusion, twitching, multifocal myoclonus, localized or generalized epileptiform seizures) may occur with large intravenous doses of the penicillinase-resistant penicillins especially in patients with renal insufficiency.

Renal Reactions

Renal tubular damage and interstitial nephritis have been associated with the administration of methicillin sodium and infrequently with the administration of nafcillin and oxacillin. Manifestations of this reaction may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency. Methicillin-induced nephropathy does not appear to be dose-related and is generally reversible upon prompt discontinuation of therapy.

Hematologic Reactions

Eosinophilia, hemolytic anemia, agranulocytosis, neutropenia, leukopenia, granulocytopenia, thrombocytopenia, and bone marrow depression have been associated with the use of penicillinase-resistant penicillins.

Hepatic Reactions

Hepatotoxicity, characterized by fever, nausea, and vomiting associated with abnormal liver function tests, mainly elevated SGOT levels, has been associated with the use of oxacillin and cloxacillin. Cholestatic hepatitis has been reported rarely. Asymptomatic, transient increases in serum concentrations of alkaline phosphatase, AST (SGOT), and ALT (SGPT) have been reported.



REPORTS OF SUSPECTED DICLOXACILLIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Dicloxacillin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dicloxacillin side effects / adverse reactions in 61 year old female

Reported by a lawyer from Denmark on 2011-11-04

Patient: 61 year old female

Reactions: Leukocytoclastic Vasculitis

Suspect drug(s):
Gentamicin
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Meropenem
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Dicloxacillin
    Indication: Antibiotic Therapy
    Start date: 2008-01-01

Clindamycin Phosphate
    Dosage: unk
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Keflex
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Zinacef
    Indication: Antibiotic Therapy
    Start date: 2008-01-01



Possible Dicloxacillin side effects / adverse reactions in 739 month old female

Reported by a lawyer from Denmark on 2011-11-09

Patient: 739 month old female

Reactions: Leukocytoclastic Vasculitis

Suspect drug(s):
Clindamycin
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Keflex
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Zinacef
    Dosage: single dose
    Indication: Antibiotic Therapy
    Start date: 2008-01-11

Dicloxacillin
    Indication: Antibiotic Therapy
    Start date: 2008-01-01

Meropenem
    Indication: Antibiotic Therapy
    Start date: 2008-05-01

Gentamicin
    Indication: Antibiotic Therapy
    Start date: 2008-05-01



See index of all Dicloxacillin side effect reports >>

Drug label data at the top of this Page last updated: 2007-09-10

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