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Diclofenac Delayed Release (Diclofenac Sodium) - Summary

 

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BOX WARNING

Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS).
  • Diclofenac sodium delayed-release tablets are contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including inflammation, bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
 

SUMMARY

Diclofenac sodium is a benzeneacetic acid derivative, designated chemically as 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monosodium salt.

Carefully consider the potential benefits and risks of diclofenac sodium delayed-release tablets and other treatment options before deciding to use diclofenac sodium delayed-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

Diclofenac sodium delayed-release tablets, are indicated:

  • For relief of signs and symptoms of osteoarthritis
  • For relief of signs and symptoms of rheumatoid arthritis
  • For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis

NEWS HIGHLIGHTS RELATED TO DICLOFENAC DELAYED RELEASE

Media Articles Related to Diclofenac Delayed Release (Diclofenac)

diclofenac and misoprostol, Arthrotec
Source: MedicineNet meloxicam Specialty [2005.12.13]

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Published Studies Related to Diclofenac Delayed Release (Diclofenac)

Diclofenac sodium and occlusal splint therapy in TMJ osteoarthritis: a randomized controlled trial. [2008.05.09]

Gastrointestinal tolerability of etoricoxib in rheumatoid arthritis patients: results of the etoricoxib vs diclofenac sodium gastrointestinal tolerability and effectiveness trial (EDGE-II). [2008.03]

Comparison of two different dosages of celecoxib with diclofenac for the treatment of active ankylosing spondylitis: results of a 12-week randomised, double-blind, controlled study. [2008.03]

Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. [2008.03]

Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. [2008.03]

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Clinical Trials Related to Diclofenac Delayed Release (Diclofenac)

Study to Compare the Pharmacokinetics of IV Diclofenac Sodium (2 Doses)Versus Oral Diclofenac Potassium [Completed]

Assess Platelet Function and Safety After Administration of Injectable Diclofenac Compared to Ketorolac and Aspirin in Adult Male Volunteers [Completed]

Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain [Active, not recruiting]

Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis [Completed]

Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis [Completed]

more>>

Page last updated: 2008-06-22

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