Diamox (Acetazolamide) - Side Effects and Adverse Reactions

Adverse Reactions

Body as a whole:

 Headache, malaise, fatigue, fever, pain at injection site, flushing, growth retardation in children, flaccid paralysis, anaphylaxis.

Digestive:

Gastrointestinal disturbances such as nausea, vomiting, diarrhea.

Hematological/Lymphatic:

Blood dyscrasias such as aplastic anemia, agranulocytosis, leukopenia, thrombocytopenic purpura, melena.

Hepato-biliary disorders:

Abnormal liver function, cholestatic jaundice, hepatic insufficiency, fulminant hepatic necrosis.

Metabolic/Nutritional:

Metabolic acidosis, electrolyte imbalance, including hypokalemia, hyponatremia, osteomalacia with long-term phenytoin therapy, loss of appetite, taste alteration, hyper/hypoglycemia.

Nervous:

Drowsiness, paresthesia (including numbness and tingling of extremities and face), depression, excitement, ataxia, confusion, convulsions, dizziness.

Skin:

Allergic skin reactions including urticaria, photosensitivity, Stevens- Johnson syndrome, toxic epidermal necrolysis.

Special senses:

Hearing disturbances, tinnitus, transient myopia.

Urogenital:

 Crystalluria, increased risk of nephrolithiasis with long-term therapy, hematuria, glycosuria, renal failure, polyuria.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO DIAMOX

Possible Diamox side effects / adverse reactions in 78 year old male

Reported by a physician from Japan on 2007-02-15

Patient: 78 year old male weighing 56.0 kg (123.2 pounds)

Reactions: Pneumonia, Anaemia, Platelet Count Decreased, Neutrophil Count Decreased, Hypokalaemia

Adverse event resulted in: death

Suspect drug(s):
Mylotarg
    Dosage: a single 9 mg/m^2 dose
    Indication: Acute Myeloid Leukaemia
    Start date: 2006-02-24
    End date: 2006-02-24

Mylotarg
    Dosage: a single 9 mg/m^2 dose
    Start date: 2006-03-10
    End date: 2006-03-10

Diamox
    Indication: Prophylaxis
    Start date: 2006-03-07
    End date: 2006-03-15

Other drugs received by patient: Diflucan

Possible Diamox side effects / adverse reactions in 78 year old male

Reported by a individual with unspecified qualification from Japan on 2007-02-22

Patient: 78 year old male

Reactions: Hyperbilirubinaemia, Pneumonia, Anaemia, General Physical Health Deterioration, Hyponatraemia, Hypokalaemia, Disease Progression, Renal Impairment, Neutropenic Infection, Platelet Count Decreased, Neutrophil Count Decreased

Adverse event resulted in: death

Suspect drug(s):
Mylotarg
    Dosage: see image
    Indication: Acute Myeloid Leukaemia
    Start date: 2006-02-24
    End date: 2006-02-24

Mylotarg
    Dosage: see image
    Indication: Acute Myeloid Leukaemia
    Start date: 2006-03-10
    End date: 2006-03-10

Diamox
    Dosage: 1000 mg 1x per 1 day intravenous
    Indication: Prophylaxis
    Start date: 2006-03-07
    End date: 2006-03-15

Other drugs received by patient: Diflucan

Possible Diamox side effects / adverse reactions in 83 year old female

Reported by a consumer/non-health professional from France on 2007-03-08

Patient: 83 year old female

Reactions: Rash Pustular, Pruritus, Lymphadenopathy, Skin Exfoliation, Drug Ineffective, Pyrexia, Eosinophilia, Generalised Erythema, Acute Generalised Exanthematous Pustulosis, Renal Impairment, Normochromic Normocytic Anaemia, Dermatitis Exfoliative, Pemphigoid, Prurigo, Inflammation

Adverse event resulted in: hospitalization

Suspect drug(s):
Amoxicillin
    Dosage: 2g single dose
    Administration route: Oral
    Indication: Premedication
    Start date: 2006-12-07
    End date: 2006-12-07

Diamox
    Dosage: 500mg single dose
    Indication: Premedication
    Start date: 2006-12-07
    End date: 2006-12-07

Doliprane
    Dosage: 1g per day
    Administration route: Oral
    Indication: Premedication
    Start date: 2006-12-06
    End date: 2006-12-07

Diprivan
    Dosage: 200mg single dose
    Indication: Cataract Operation
    Start date: 2006-12-07
    End date: 2006-12-07

Xylocaine
    Dosage: 1app single dose
    Indication: Premedication
    Start date: 2006-12-07
    End date: 2006-12-07

Other drugs received by patient: Methotrexate; Atarax; Speciafoldine; Furosemide; Diffu K; Tardyferon; Atenolol; Zocor