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Diabinese (Chlorpropamide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Body as a Whole

Disulfiram-like reactions have rarely been reported with DIABINESE (see DRUG INTERACTIONS).

Central and Peripheral Nervous System

Dizziness and headache.

Hypoglycemia

See PRECAUTIONS and OVERDOSAGE sections.

Gastrointestinal

Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. Other gastrointestinal disturbances have occurred in less than 1% of patients including proctocolitis. They tend to be dose-related and may disappear when dosage is reduced.

Liver/Biliary

Cholestatic jaundice may occur rarely; DIABINESE should be discontinued if this occurs. Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE.

Skin/Appendages

Pruritus has been reported in less than 3% of patients. Other allergic skin reactions, e.g., urticaria and maculopapular eruptions have been reported in approximately 1% or less of patients. These may be transient and may disappear despite continued use of DIABINESE; if skin reactions persist the drug should be discontinued.

As with other sulfonylureas, porphyria cutanea tarda and photosensitivity reactions have been reported.

Skin eruptions rarely progressing to erythema multiforme and exfoliative dermatitis have also been reported.

Hematologic Reactions

Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia (see PRECAUTIONS), aplastic anemia, pancytopenia, and eosinophilia have been reported with sulfonylureas.

Metabolic/Nutritional Reactions

Hypoglycemia (see PRECAUTIONS and OVERDOSAGE sections). Hepatic porphyria and disulfiram-like reactions have been reported with DIABINESE. See DRUG INTERACTIONS section.

Endocrine Reactions

On rare occasions, chlorpropamide has caused a reaction identical to the syndrome of inappropriate antidiuretic hormone (ADH) secretion. The features of this syndrome result from excessive water retention and include hyponatremia, low serum osmolality, and high urine osmolality. This reaction has also been reported for other sulfonylureas.



REPORTS OF SUSPECTED DIABINESE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Diabinese. The information is not vetted and should not be considered as verified clinical evidence.

Possible Diabinese side effects / adverse reactions in 72 year old female

Reported by a physician from Brazil on 2011-10-26

Patient: 72 year old female

Reactions: Hypoglycaemia, Diabetic Nephropathy, Hyperuricaemia, Infection

Adverse event resulted in: hospitalization

Suspect drug(s):
Diabinese
    Dosage: 125 mg, daily
    Administration route: Oral
    Start date: 2000-08-10

Diabinese
    Dosage: 125 mg, 1x/day

Diabinese
    Dosage: 250 mg, daily
    Administration route: Oral
    Start date: 2002-01-01

Diovan
    Dosage: 160 mg, 1x/day

Diovan
    Dosage: 80 mg, daily

Other drugs received by patient: Allopurinol; Lescol; Captopril; Aspirin



Possible Diabinese side effects / adverse reactions in 74 year old female

Reported by a consumer/non-health professional from Peru on 2012-01-30

Patient: 74 year old female

Reactions: Drug Ineffective, Haemoglobin Decreased, Glycosylated Haemoglobin Increased, Limb Injury, Oedema Peripheral, Blood Uric Acid Increased, Shock Hypoglycaemic, Walking Disability

Adverse event resulted in: hospitalization

Suspect drug(s):
Diabinese



See index of all Diabinese side effect reports >>

Drug label data at the top of this Page last updated: 2009-03-04

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