WARNING
AMPHETAMINES HAVE A HIGH POTENTIAL FOR ABUSE. ADMINISTRATION OF AMPHETAMINES FOR PROLONGED PERIODS OF TIME MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING AMPHETAMINES FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUGS SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY.
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DEXTROSTAT SUMMARY
DEXTROSTAT® CII
Dextroamphetamine Sulfate Tablets, USP Rx Only
DextroStat® (dextroamphetamine sulfate) is the dextro isomer of the compound
d,l-amphetamine sulfate, a sympathomimetic amine of the amphetamine group.
Dextroamphetamine sulfate tablets are indicated:
- In Narcolepsy.
- In Attention Deficit Disorder with Hyperactivity, as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 to 16 years) with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.
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NEWS HIGHLIGHTS
Published Studies Related to Dextrostat (Dextroamphetamine)
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. [2009.02.01]
OBJECTIVES: Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making... CONCLUSIONS: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil. [2008.09]
INTRODUCTION: Sleep deprivation alters risk-related judgments, decision-making, and behavioral control. Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored... CONCLUSIONS: Stimulant medications, particularly dextroamphetamine, sustained risk-related attitudes and behavior during continuous wakefulness. The extent to which stimulants restore other aspects of judgment during sleep loss remains to be determined.
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. [2008.09]
Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities... Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment.
Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. [2008.06]
Apathy is a common behavioral symptom of Alzheimer's disease (AD), being present in up to 70% of patients. Apathy in AD and non-AD populations has been associated with dysfunction in the dopaminergic brain reward system, suggesting that pharmacotherapeutic targeting of this system may be an effective treatment for apathy in AD...
Relative bioavailability of scopolamine dosage forms and interaction with dextroamphetamine. [2007.07]
The NASA Reduced Gravity Office (RGO) uses scopolamine (SCOP) alone and in combination with dextoamphetamine (DEX) to treat motion sickness symptoms during DC-9 parabolic flights.
Clinical Trials Related to Dextrostat (Dextroamphetamine)
Tranylcypromine, Tranylcypromine Plus Dextroamphetamine and Tranylcypromine Plus Triiodothyronine as Treatment for Refractory Depression [Terminated]
This pilot study will assess the efficacy of several sequential pharmacological treatments
for patients with Refractory Depression.
Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-Deficit Hyperactivity Disorder (ADHD) [Recruiting]
Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this
medication may decrease drug use in individuals dependent on cocaine. Thus, the present pilot
study will determine the ability of dextroamphetamine to treat individuals with both cocaine
dependence and ADHD.
Dextro-Amphetamine Versus Caffeine in Treatment-Resistant OCD [Active, not recruiting]
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective
when used to augment treatment for OCD, and that tolerance (loss of therapeutic effect) to
the medication will not develop over a period of several weeks.
Dextroamphetamine-Cocaine Behavioral Intervention - 5 [Completed]
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1 [Completed]
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Dextrostat has an overall score of 10. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Dextrostat review by 40 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | ADD |
| Dosage & duration: | | 20 mg taken once daily for the period of 4 months so far |
| Other conditions: | | mild seasonal depression |
| Other drugs taken: | | effexor | | |
Reported Results |
| Benefits: | | increased concentration, additional energy, able to complete projects, more patient with my children and now volunteer in my spare time helping children. |
| Side effects: | | none |
| Comments: | | Was started on 2.5 mg daily and was increased slowly. I never finished school, back then we didnt have add/adhd just lazy students. I wanted to finish school for twenty four years and never could.. I recently took my GED and passed. I am now looking into college courses. I do feel I could benefit from a slight increase in my dose or a longer acting does as I lose concentration around early evening (study time) |
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Page last updated: 2009-10-20
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