WARNING
AMPHETAMINES HAVE A HIGH POTENTIAL FOR ABUSE. ADMINISTRATION OF AMPHETAMINES FOR PROLONGED PERIODS OF TIME MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING AMPHETAMINES FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUGS SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY.
MISUSE OF AMPHETAMINES MAY CAUSE SUDDEN DEATH AND SERIOUS CARDIOVASCULAR ADVERSE EVENTS.
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SUMMARY
Dextroamphetamine sulfate is the dextro isomer of the compound d,l- amphetamine sulfate, a sympathomimetic amine of the amphetamine group.
Dextroamphetamine Sulfate Extended-Release Capsules are indicated:
- In Narcolepsy.
- In Attention Deficit Disorder with Hyperactivity, as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.
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NEWS HIGHLIGHTS
Published Studies Related to Dextroamphetamine
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. [2009.02.01]
OBJECTIVES: Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making... CONCLUSIONS: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil. [2008.09]
INTRODUCTION: Sleep deprivation alters risk-related judgments, decision-making, and behavioral control. Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored... CONCLUSIONS: Stimulant medications, particularly dextroamphetamine, sustained risk-related attitudes and behavior during continuous wakefulness. The extent to which stimulants restore other aspects of judgment during sleep loss remains to be determined.
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. [2008.09]
Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities... Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment.
Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. [2008.06]
Apathy is a common behavioral symptom of Alzheimer's disease (AD), being present in up to 70% of patients. Apathy in AD and non-AD populations has been associated with dysfunction in the dopaminergic brain reward system, suggesting that pharmacotherapeutic targeting of this system may be an effective treatment for apathy in AD...
Relative bioavailability of scopolamine dosage forms and interaction with dextroamphetamine. [2007.07]
The NASA Reduced Gravity Office (RGO) uses scopolamine (SCOP) alone and in combination with dextoamphetamine (DEX) to treat motion sickness symptoms during DC-9 parabolic flights.
Clinical Trials Related to Dextroamphetamine
Tranylcypromine, Tranylcypromine Plus Dextroamphetamine and Tranylcypromine Plus Triiodothyronine as Treatment for Refractory Depression [Terminated]
This pilot study will assess the efficacy of several sequential pharmacological treatments
for patients with Refractory Depression.
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1 [Completed]
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3 [Completed]
Dextroamphetamine-Cocaine Behavioral Intervention - 5 [Completed]
Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-Deficit Hyperactivity Disorder (ADHD) [Recruiting]
Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this
medication may decrease drug use in individuals dependent on cocaine. Thus, the present pilot
study will determine the ability of dextroamphetamine to treat individuals with both cocaine
dependence and ADHD.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Dextroamphetamine has an overall score of 8.50. The effectiveness score is 9 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Dextroamphetamine review by 36 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | ADD and Depression |
| Dosage & duration: | | 60m (dosage frequency: 1 pid) for the period of one month |
| Other conditions: | | anxiety |
| Other drugs taken: | | Cymbalta | | |
Reported Results |
| Benefits: | | Clear headed, Able to complete projects without procastination, 100% help with short-term memory, lessened depression and anxiety, no more obsessive eating, weight loss... |
| Side effects: | | Dry mouth (which is great because I now drink a lot of water instead of sodas because the sodas don't quinch my thirst) |
| Comments: | | I have been on antidepression meds for 15 years, but my depression persisted regardless of the treatment. I used to sleep 12-16 hours per day and was always tired and fatigued when awake. I was diagnosed with sleep apnea 5 years ago, but even sleeping with CPAP did not help with my daytime fatigue. After seeing MANY family practitioners, I finally broke down and INVESTED in a very well educated Psychiatrist who diagnoed me with ADD since childhood. His decision to prescribe Vyvanse was brilliant! I feel better than ever and am totally clear headed and able to consentrate. For the first time in as long as I can remember, I can think normally! No more racing thoughts in my head, and my depression and anxiety has all but vanashed! I do still take an antidepressive, but I am CERTAIN that the Vyvanse gave the antidepression meds the ability to work. I can FINALLY sleep a normal 7 to 9 hours and still be awake and alert throughout my 12-hour work days. I was worried that the Vyvanse would elevate my anxiety level, but the opposite occured! My anxiety is all but absent, and I no longer have the need to continue with my anti-anxiety meds! There is NO SUBSTITUTE for a Doctor who is a specialist in mental health. Spend the money and see! A good Psychiatrist will spend HOURS with you before making a diagnosis, and if Adult ADD is what you have, then give Vyvanse a try. It worked GREAT for me and my live has turned around for the better. It is the best remedy that I have found in 15 years! You MUST take it when you awaken for your day, because it takes about 12-15 hours to get out of your system. If you take it later in the day - you will experaince insomnia. Ask your SPECIALIST about Vyvanse... |
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| | Dextroamphetamine review by 32 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | ADD |
| Dosage & duration: | | 5mg 8x/day taken every day for the last two years for the period of still taking |
| Other conditions: | | depression |
| Other drugs taken: | | wellbutrin | | |
Reported Results |
| Benefits: | | My depression has lifted and I am able to concentrate more than I was previuosly |
| Side effects: | | weight loss and loss of appetite |
| Comments: | | simply remember to take medication |
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Page last updated: 2009-10-20
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