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Dextroamphetamine (Dextroamphetamine Sulfate) - Summary

 
 



WARNING

AMPHETAMINES HAVE A HIGH POTENTIAL FOR ABUSE. ADMINISTRATION OF AMPHETAMINES FOR PROLONGED PERIODS OF TIME MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING AMPHETAMINES FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUGS SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY.

MISUSE OF AMPHETAMINES MAY CAUSE SUDDEN DEATH AND SERIOUS CARDIOVASCULAR ADVERSE EVENTS.

 

SUMMARY

Dextroamphetamine sulfate is the dextro isomer of the compound d,l- amphetamine sulfate, a sympathomimetic amine of the amphetamine group.

Dextroamphetamine Sulfate Extended-Release Capsules are indicated:

  1. In Narcolepsy.
  2. In Attention Deficit Disorder with Hyperactivity, as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.

See all Dextroamphetamine indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Dextroamphetamine

A randomized, placebo-controlled trial of sustained-release dextroamphetamine for treatment of methamphetamine addiction. [2011.02]
Sixty treatment-seeking individuals with methamphetamine (MA) dependence entered a randomized, placebo-controlled, double-blind clinical trial of oral dextroamphetamine (d-AMP) as a replacement therapy for MA dependence. The subjects took 60 mg sustained-release d-AMP for 8 weeks, during which time they received eight 50-min sessions of individual psychotherapy...

Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans. [2011.01]
RATIONALE: Minocycline, a tetracycline antibiotic, interacts with brain glutamate and dopamine neurotransmission. In preclinical studies, minocycline attenuated amphetamine-induced acute dopamine release and subsequent behavioral sensitization. The goal of this study was to determine minocycline's effects on the acute physiological, behavioral, and subjective responses to dextroamphetamine (DAMP) in healthy volunteers... CONCLUSIONS: These findings warrant further studies examining the potential use of minocycline for stimulant addiction.

A randomized, placebo-controlled trial of sustained-release dextroamphetamine for treatment of methamphetamine addiction. [2011]
Sixty treatment-seeking individuals with methamphetamine (MA) dependence entered a randomized, placebo-controlled, double-blind clinical trial of oral dextroamphetamine (d-AMP) as a replacement therapy for MA dependence. The subjects took 60 mg sustained-release d-AMP for 8 weeks, during which time they received eight 50-min sessions of individual psychotherapy...

Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. [2009.11]
CONCLUSIONS: Larger, double-blind, placebo-controlled trials of both d-amphetamine and caffeine augmentation are needed in OCD subjects inadequately responsive to adequate doses of an SSRI or SNRI. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00363298. Copyright 2009 Physicians Postgraduate Press, Inc.

Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. [2009.02.01]
OBJECTIVES: Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making... CONCLUSIONS: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.

more studies >>

Clinical Trials Related to Dextroamphetamine

Tranylcypromine, Tranylcypromine Plus Dextroamphetamine and Tranylcypromine Plus Triiodothyronine as Treatment for Refractory Depression [Terminated]
This pilot study will assess the efficacy of several sequential pharmacological treatments for patients with Refractory Depression.

Study to Evaluate Safety & Efficacy of d-Amphetamine Transdermal System Compared to Placebo in Children & Adolescents With ADHD [Recruiting]
This study will evaluate safety and efficacy of d-Amphetamine Transdermal System for the treatment of Attention Deficit Hyperactivity Disorder in children and adolescents.

Spectroscopic Imaging at 4T: A Drug Challenge Study [Recruiting]
An advanced technique for rapid magnetic resonance proton spectroscopic imaging (1H-MRSI) will be employed in a drug challenge study in healthy volunteers to spatially map and measure acute changes in the brain chemicals GABA, glutamate and glutamine after administration of a drug. Three condition will be tested in a double-blind fashion, i)depressant, ii)stimulant, iii)placebo. It is hypothesized that unique and reproducible spatial and directional metabolic response patterns will be observed, unique to each condition within the brain.

Dextroamphetamine as an Adjunct in Cocaine Treatment - 1 [Completed]

Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3 [Completed]

more trials >>

Reports of Suspected Dextroamphetamine Side Effects

Aggression (6)Coordination Abnormal (5)Feeling Abnormal (5)Completed Suicide (4)Nausea (4)Muscular Weakness (4)Ataxia (4)Gait Disturbance (4)Dyskinesia (3)Somnolence (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Dextroamphetamine has an overall score of 8.33. The effectiveness score is 9.33 and the side effect score is 7.33. The scores are on ten point scale: 10 - best, 1 - worst.
 

Dextroamphetamine review by 36 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   ADD and Depression
Dosage & duration:   60m (dosage frequency: 1 pid) for the period of one month
Other conditions:   anxiety
Other drugs taken:   Cymbalta
  
Reported Results
Benefits:   Clear headed, Able to complete projects without procastination, 100% help with short-term memory, lessened depression and anxiety, no more obsessive eating, weight loss...
Side effects:   Dry mouth (which is great because I now drink a lot of water instead of sodas because the sodas don't quinch my thirst)
Comments:   I have been on antidepression meds for 15 years, but my depression persisted regardless of the treatment. I used to sleep 12-16 hours per day and was always tired and fatigued when awake. I was diagnosed with sleep apnea 5 years ago, but even sleeping with CPAP did not help with my daytime fatigue. After seeing MANY family practitioners, I finally broke down and INVESTED in a very well educated Psychiatrist who diagnoed me with ADD since childhood. His decision to prescribe Vyvanse was brilliant! I feel better than ever and am totally clear headed and able to consentrate. For the first time in as long as I can remember, I can think normally! No more racing thoughts in my head, and my depression and anxiety has all but vanashed! I do still take an antidepressive, but I am CERTAIN that the Vyvanse gave the antidepression meds the ability to work. I can FINALLY sleep a normal 7 to 9 hours and still be awake and alert throughout my 12-hour work days. I was worried that the Vyvanse would elevate my anxiety level, but the opposite occured! My anxiety is all but absent, and I no longer have the need to continue with my anti-anxiety meds! There is NO SUBSTITUTE for a Doctor who is a specialist in mental health. Spend the money and see! A good Psychiatrist will spend HOURS with you before making a diagnosis, and if Adult ADD is what you have, then give Vyvanse a try. It worked GREAT for me and my live has turned around for the better. It is the best remedy that I have found in 15 years! You MUST take it when you awaken for your day, because it takes about 12-15 hours to get out of your system. If you take it later in the day - you will experaince insomnia. Ask your SPECIALIST about Vyvanse...

 

Dextroamphetamine review by 27 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   ADD
Dosage & duration:   10mg taken 4 times daily for the period of 2 months
Other conditions:   Depression
Other drugs taken:   Lexapro
  
Reported Results
Benefits:   Smoother more gradual onset and effect than Adderall. Effective at controlling ADD symptoms previously controlled by Adderall however this drug seems more natural and transparent. Less tension and anxiety. Less "druggy" unnatural feelings and thoughts.
Side effects:   Dexerine IR tablets need to be taken more often than adderall and also wear off more abruptly. Generic tablets are not high quality and somewhat expensive due to the need for a large quantity of tablets.
Comments:   Switched from Adderall to Dexedrine to compare the effects. Dexedrine is simply dextroamphetamine while Adderall is a mixture of Amphetamine salts. This might explain the increased effectiveness of the Dexedrine contrary to popular belief. I found it important to take several relatively low doses frequently to achieve a balanced effect.

 

Dextroamphetamine review by 27 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   ADD
Dosage & duration:   10mg taken 4 times daily for the period of 2 months
Other conditions:   Depression
Other drugs taken:   Lexapro
  
Reported Results
Benefits:   Smoother more gradual onset and effect than Adderall. Effective at controlling ADD symptoms previously controlled by Adderall however this drug seems more natural and transparent. Less tension and anxiety. Less "druggy" unnatural feelings and thoughts.
Side effects:   Dexerine IR tablets need to be taken more often than adderall and also wear off more abruptly. Generic tablets are not high quality and somewhat expensive due to the need for a large quantity of tablets.
Comments:   Switched from Adderall to Dexedrine to compare the effects. Dexedrine is simply dextroamphetamine while Adderall is a mixture of Amphetamine salts. This might explain the increased effectiveness of the Dexedrine contrary to popular belief. I found it important to take several relatively low doses frequently to achieve a balanced effect.

See all Dextroamphetamine reviews / ratings >>

Page last updated: 2013-02-10

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