BOX WARNING WARNING
AMPHETAMINES HAVE A HIGH POTENTIAL FOR ABUSE. ADMINISTRATION OF AMPHETAMINES FOR PROLONGED PERIODS OF TIME MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING AMPHETAMINES FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUGS SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY.
MISUSE OF AMPHETAMINES MAY CAUSE SUDDEN DEATH AND SERIOUS CARDIOVASCULAR ADVERSE EVENTS.
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DEXEDRINE SUMMARY
DEXEDRINE (dextroamphetamine sulfate) is the dextro isomer of the compound
d,l
-amphetamine sulfate, a sym-pathomimetic amine of the amphetamine group.
DEXEDRINE is indicated:
- In Narcolepsy.
- In Attention Deficit Disorder with Hyperactivity, as an integral part of a total treatment program that typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in pediatric patients (ages 3 years to 16 years) with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: Moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.
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NEWS HIGHLIGHTS
Published Studies Related to Dexedrine (Dextroamphetamine)
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. [2009.02.01]
OBJECTIVES: Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making... CONCLUSIONS: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil. [2008.09]
INTRODUCTION: Sleep deprivation alters risk-related judgments, decision-making, and behavioral control. Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored... CONCLUSIONS: Stimulant medications, particularly dextroamphetamine, sustained risk-related attitudes and behavior during continuous wakefulness. The extent to which stimulants restore other aspects of judgment during sleep loss remains to be determined.
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness. [2008.09]
Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities... Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment.
Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. [2008.06]
Apathy is a common behavioral symptom of Alzheimer's disease (AD), being present in up to 70% of patients. Apathy in AD and non-AD populations has been associated with dysfunction in the dopaminergic brain reward system, suggesting that pharmacotherapeutic targeting of this system may be an effective treatment for apathy in AD...
Relative bioavailability of scopolamine dosage forms and interaction with dextroamphetamine. [2007.07]
The NASA Reduced Gravity Office (RGO) uses scopolamine (SCOP) alone and in combination with dextoamphetamine (DEX) to treat motion sickness symptoms during DC-9 parabolic flights.
Clinical Trials Related to Dexedrine (Dextroamphetamine)
Tranylcypromine, Tranylcypromine Plus Dextroamphetamine and Tranylcypromine Plus Triiodothyronine as Treatment for Refractory Depression [Terminated]
This pilot study will assess the efficacy of several sequential pharmacological treatments
for patients with Refractory Depression.
Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-Deficit Hyperactivity Disorder (ADHD) [Recruiting]
Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this
medication may decrease drug use in individuals dependent on cocaine. Thus, the present pilot
study will determine the ability of dextroamphetamine to treat individuals with both cocaine
dependence and ADHD.
Dextro-Amphetamine Versus Caffeine in Treatment-Resistant OCD [Active, not recruiting]
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective
when used to augment treatment for OCD, and that tolerance (loss of therapeutic effect) to
the medication will not develop over a period of several weeks.
Dextroamphetamine-Cocaine Behavioral Intervention - 5 [Completed]
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1 [Completed]
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Dexedrine has an overall score of 3. The effectiveness score is 2 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
| | Dexedrine review by 25 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Ineffective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | Supposed ADHD |
| Dosage & duration: | | 5 MG Caps taken 2xs daily for the period of Not more than 4 months |
| Other conditions: | | Not so sure I even had ADHD |
| Other drugs taken: | | Depekote | | |
Reported Results |
| Benefits: | | With less Dexedrine and minimal Depekote, I was able to sleep deeply when I finally did fall asleep. I also remember extremely vivid dreams. The house was kept super clean and I was motivated to finish tasks. |
| Side effects: | | Horrible feeling. My heart felt like it would explode. I had horrible tic like behavior. I picked at my skin until permanently damaged. I had horrible dry mouth and I had bad breath. |
| Comments: | | My sister was diagnosed with ADHD and so was my brother (Both were much younger 11 and 7 years younger) Both suffered from learning disabilities. I drove my sister to an appointment and due to my family history I was asked to take a questionair. I was then told that while I was not learning disabled (A Student), I was hyper and did I want to try the above drugs. They said I would never know how bad off I was until I knew what it felt like to be normal. I was given two perscriptions and was told to start with one dose of the dexedrine in the am and to take the Depekote and dexedrine in the afternoon. If that didn't do it they would up my dexedrine. With in about two months I felt like jumping from my skin and decided that organization was not that worth it. My skin still shows the scarring from all the picking and squeezing but my tone is no longer "death warmed over".
PS the doctor that prescribed this to me was investigated, tried and convicted of over prescribing, drug dealing and improper relationships with patients. (I can't remember the exact charges but he did get about 16 years for dealing controlled substances and was turned in by two female patients who said that he took advantage of their situation and slept with them.) |
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Page last updated: 2009-10-20
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