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Dexamethasone (Dexamethasone) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

(listed alphabetically, under each subsection)

The following adverse reactions have been reported with dexamethasone or other corticosteroids:

Allergic Reactions

Anaphylactoid reaction, anaphylaxis, angioedema.

Cardiovascular

Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS: Cardio-Renal), edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.

Dermatologic

Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impaired wound healing, increased sweating, rash, striae, suppression of reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.

Endocrine

Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.

Fluid and Electrolyte Disturbances

Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.

Gastrointestinal

Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.

Metabolic

Negative nitrogen balance due to protein catabolism.

Musculoskeletal

Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.

Neurological/Psychiatric

Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.

Ophthalmic

Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.

Other

Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.



REPORTS OF SUSPECTED DEXAMETHASONE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Dexamethasone. The information is not vetted and should not be considered as verified clinical evidence.

Possible Dexamethasone side effects / adverse reactions in 58 year old female

Reported by a physician from Australia on 2011-10-03

Patient: 58 year old female

Reactions: Pyomyositis

Adverse event resulted in: hospitalization

Suspect drug(s):
Paclitaxel
    Indication: Endometrial Cancer Stage III

Dexamethasone
    Dosage: 40 mg
    Indication: Premedication

Dexamethasone
    Dosage: 4 mg
    Indication: Prophylaxis of Nausea and Vomiting

Carboplatin
    Dosage: 600 mg
    Indication: Endometrial Cancer Stage III



Possible Dexamethasone side effects / adverse reactions in 16 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-03

Patient: 16 year old male

Reactions: Psychotic Disorder, Nausea, Mental Status Changes, Neutropenia, Hepatic Enzyme Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Dexamethasone
    Dosage: 6.00-mg-1.0days;
    Indication: Nausea

Cisplatin
    Dosage: 20.00-mg/m2-
    Indication: Testicular Germ Cell Cancer

Etoposide
    Dosage: 100.00-mg/m2-
    Indication: Testicular Germ Cell Cancer

Bleomycin Sulfate
    Dosage: 30.00-mg-
    Indication: Testicular Germ Cell Cancer

Other drugs received by patient: Ondansetron; Promethazine



Possible Dexamethasone side effects / adverse reactions in 59 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-03

Patient: 59 year old male weighing 71.0 kg (156.2 pounds)

Reactions: Plasmacytoma, Pneumonia, Acute Myocardial Infarction

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Dexamethasone
    Dosage: 40 milligram
    Indication: Multiple Myeloma
    Start date: 2011-07-01
    End date: 2011-07-22

Dexamethasone
    Start date: 2011-09-23

Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2011-07-01
    End date: 2011-07-21

Dexamethasone
    Dosage: 40 milligram
    Start date: 2011-07-29
    End date: 2011-08-05

Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Start date: 2011-07-29
    End date: 2011-08-11

Other drugs received by patient: Avelox; Avelox



See index of all Dexamethasone side effect reports >>

Drug label data at the top of this Page last updated: 2007-10-25

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