ADVERSE REACTIONS
(listed alphabetically, under each subsection)
The following adverse reactions have been reported with dexamethasone or other corticosteroids:
Allergic Reactions
Anaphylactoid reaction, anaphylaxis, angioedema.
Cardiovascular
Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS: Cardio-Renal), edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.
Dermatologic
Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impaired wound healing, increased sweating, rash, striae, suppression of reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.
Endocrine
Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.
Fluid and Electrolyte Disturbances
Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.
Gastrointestinal
Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.
Metabolic
Negative nitrogen balance due to protein catabolism.
Musculoskeletal
Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.
Neurological/Psychiatric
Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.
Ophthalmic
Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.
Other
Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.
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REPORTS OF SUSPECTED DEXAMETHASONE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Dexamethasone. The information is not vetted and should not be considered as verified clinical evidence.
Possible Dexamethasone side effects / adverse reactions in 58 year old female
Reported by a physician from Australia on 2011-10-03
Patient: 58 year old female
Reactions: Pyomyositis
Adverse event resulted in: hospitalization
Suspect drug(s):
Paclitaxel
Indication: Endometrial Cancer Stage III
Dexamethasone
Dosage: 40 mg
Indication: Premedication
Dexamethasone
Dosage: 4 mg
Indication: Prophylaxis of Nausea and Vomiting
Carboplatin
Dosage: 600 mg
Indication: Endometrial Cancer Stage III
Possible Dexamethasone side effects / adverse reactions in 16 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-03
Patient: 16 year old male
Reactions: Psychotic Disorder, Nausea, Mental Status Changes, Neutropenia, Hepatic Enzyme Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Dexamethasone
Dosage: 6.00-mg-1.0days;
Indication: Nausea
Cisplatin
Dosage: 20.00-mg/m2-
Indication: Testicular Germ Cell Cancer
Etoposide
Dosage: 100.00-mg/m2-
Indication: Testicular Germ Cell Cancer
Bleomycin Sulfate
Dosage: 30.00-mg-
Indication: Testicular Germ Cell Cancer
Other drugs received by patient: Ondansetron; Promethazine
Possible Dexamethasone side effects / adverse reactions in 59 year old male
Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-03
Patient: 59 year old male weighing 71.0 kg (156.2 pounds)
Reactions: Plasmacytoma, Pneumonia, Acute Myocardial Infarction
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Dexamethasone
Dosage: 40 milligram
Indication: Multiple Myeloma
Start date: 2011-07-01
End date: 2011-07-22
Dexamethasone
Start date: 2011-09-23
Revlimid
Dosage: 25 milligram
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2011-07-01
End date: 2011-07-21
Dexamethasone
Dosage: 40 milligram
Start date: 2011-07-29
End date: 2011-08-05
Revlimid
Dosage: 25 milligram
Administration route: Oral
Start date: 2011-07-29
End date: 2011-08-11
Other drugs received by patient: Avelox; Avelox
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