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Dexamethasone (Dexamethasone) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

DEXAMETHASONE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Reports of acute toxicity and/or death following overdosage of glucocorticoids are rare.  In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic.

The oral LD50 of dexamethasone in female mice was 6.5 g/kg.  The intravenous LD50 of dexamethasone sodium phosphate in female mice was 794 mg/kg.

CONTRAINDICATIONS

Systemic fungal infections (see WARNINGS   regarding amphotericin B).

Hypersensitivity to any component of this product (see   WARNINGS ) .

REFERENCES

  1. Cavanagh, D.; Singh, K.B.: Endotoxin shock in pregnancy and abortion, in: “Corticosteroids in the Treatment of Shock”, Schumer, W.; Nyhus, L.M., Editors, Urbana, University of Illinois Press, 1970, pp. 86-96.
  2. Dietzman, R.H.; Ersek, R.A.; Bloch, J.M.; Lilleheir, R.C.: High-output, low-resistance gram-negative septic shock in man, Angiology 20 : 691-700, Dec. 1969.
  3. Frank, E.: Clinical observations in shock and management (in: Shields, T.F., ed.: Symposium on current concepts and management of shock), J. Maine Med. Ass. 59 : 195-200, Oct. 1968.
  4. Oaks, W. W.; Cohen, H.E.: Endotoxin shock in the geriatric patient, Geriat. 22 : 120-130, Mar. 1967.
  5. Schumer, W.; Nyhus, L.M.: Corticosteroid effect on biochemical parameters of human oligemic shock, Arch. Surg. 100 : 405-408, Apr. 1970.

 45955D

 Revised: April 2008

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