Detrol (Tolterodine Tartrate) - Summary

DETROL SUMMARY

DETROL Tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist.

DETROL Tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

See all Detrol indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Detrol (Tolterodine)

Effects of terazosin and tolterodine on ureteral stent related symptoms: a double-blind placebo-controlled randomized clinical trial. [2013]
discomfort... CONCLUSIONS: Terazosin plus tolterodine improves ureteral stent-related

Efficacy of tolterodine for medical treatment of intramural ureteral stone with vesical irritability. [2011.06]
We evaluated the clinical results of tolterodine in treating impacted stones in the intramural ureter with symptoms of vesical irritability. A total of 80 patients with intramural ureter stones were included in the study from December 2007 to November 2009... While our study demonstrated no improvement in expulsion rate, Tolterodine reduced the common symptoms of frequency, urgency, intensity of the pain episodes and discomfort often associated with intramural ureter stone.

Superior efficacy of fesoterodine over tolterodine extended release with rapid onset: a prospective, head-to-head, placebo-controlled trial. [2011.05]
OBJECTIVE: * To show the superior efficacy of fesoterodine over tolterodine extended release (ER) in a placebo-controlled overactive bladder (OAB) trial with predefined treatment comparisons for both diary measures and patient-reported outcomes... CONCLUSIONS: * In this randomized study, which is the largest to compare antimuscarinic efficacy performed to date, fesoterodine 8 mg was superior to tolterodine ER 4 mg for UUI episodes, micturitions and urgency episodes, as well as for self-reported patient assessments of bladder-related problems, urgency, symptom bother and health-related quality of life. * The superiority of fesoterodine 8 mg over tolterodine ER 4 mg was observed as early as 3 weeks after escalation from fesoterodine 4 mg for most outcomes. These data may have important implications for the clinical management of OAB patients previously treated with tolterodine ER. (c) 2010 THE AUTHORS. BJU INTERNATIONAL (c) 2010 BJU INTERNATIONAL.

[Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity]. [2011.04]
OBJECTIVE: To evaluate the efficacy and safety of Tolterodine Tartrate combined with the alpha-receptor blocker in the treatment of benign prostatic hyperplasia with detrusor overactivity (BPH-DO)... CONCLUSION: The combined use of Tolterodine Tartrate and the alpha-receptor blocker can effectively relieve the symptoms of dysuria, urinary frequency and urinary urgency in patients with BPH-DO, with neither significant adverse effects on the maximum flow rate and residual urine volume nor increase in the incidence of acute urinary retention.

The efficacy of additive tolterodine extended release for 1-year in older men with storage symptoms and clinical benign proastatic hyperplasia. [2011.04]
AIM: To determine the efficacy of toterodine extended release (ER) treatment for 1 year in older men with benign prostatic hyperplasia (BPH) and storage symptoms treated with alpha-blockers and/or 5-alpha-reductase inhibitors (5ARI)... CONCLUSIONS: This longer comparative study indicated that additive treatment with tolterodine ER in older men with BPH/BOO and significant storage symptoms is a beneficial and safe therapeutic option. Copyright (c) 2011 Wiley-Liss, Inc.

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Clinical Trials Related to Detrol (Tolterodine)

A Study to Evaluate Tolerability and Patient Preference Between Myrbetriq® and Detrol® LA in Subjects With Overactive Bladder (OAB) [Active, not recruiting]
The purpose of this study is to assess tolerability of Myrbetriq compared to Detrol LA in the treatment of subjects with Overactive Bladder (OAB). This study will also assess patient preference, safety and tolerability of Myrbetriq and Detrol LA in subjects with symptoms of OAB as well as the impact of treatment on micturition frequency and incontinence episodes.

Tolterodine Drug Use Investigation.(Post Marketing Commitment Plan) [Completed]
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the Package Insert (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3) factors considered to affect the safety and/or efficacy of this drug.

Dutasteride With Tolterodine ER or Placebo to Treat Lower Urinary Tract Symptoms (LUTS) [Completed]
This is an investigator-initiated study of safety, efficacy and tolerability of dutasteride given for 18 months, including a 1-year double-blind randomized co-administration with either tolterodine ER or placebo in men suffering from lower urinary tract symptoms (LUTS) including urgency and frequency, with or without urgency urinary incontinence (i. e., overactive bladder (OAB) symptoms).

Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects [Completed]
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older

A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause. [Terminated]
This study is being done to compare frequency of urination during the night when women take tolterodine tablets vs. when they take placebo tablets. We will also measure whether between these two treatment conditions there are any differences in women's sleep, mood and performance on cognitive tests.

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Reports of Suspected Detrol (Tolterodine) Side Effects

Drug Ineffective (29),  DRY Mouth (11),  Urinary Incontinence (8),  Rash (8),  Constipation (7),  Vomiting (7),  Abdominal Pain Upper (6),  Pneumonia (6),  Bladder Disorder (6),  Mental Status Changes (5), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Detrol review by 51 year old female patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		urgency to urinate
Dosage & duration:		4mg taken 1x day for the period of 3 mo
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		some reduced frequency in urination. didn't seem to reduce urgency a;lkjd ajalkd; adlfjsldj safljslfk fdsakjs sfdlkjsl salfjsdl sdfljlksd lksdafkj;s saldfjslk sdfkslfkj sdflkjslk
Side effects:		dry mouth, thirst. alsdfjl asldfjslk sfldkjlkjs sldfkjsl sljkljksdf ljsadflk sdf slkdjafl sdljlk sldfjklsak sdalkj slkjsdlkj ljsljflk sllkjsdflkj
Comments:		take once per day. was told it could take up to 6 weeks to see any results. took once per day as prescribed in the mornings with water but without food.