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Detrol LA (Tolterodine Tartrate) - Summary



DETROL LA Capsules contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist.

DETROL LA Capsules is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency [see CLINICAL STUDIES ].

See all Detrol LA indications & dosage >>


Published Studies Related to Detrol LA (Tolterodine)

Effects of terazosin and tolterodine on ureteral stent related symptoms: a double-blind placebo-controlled randomized clinical trial. [2013]
discomfort... CONCLUSIONS: Terazosin plus tolterodine improves ureteral stent-related

Efficacy of tolterodine for medical treatment of intramural ureteral stone with vesical irritability. [2011.06]
We evaluated the clinical results of tolterodine in treating impacted stones in the intramural ureter with symptoms of vesical irritability. A total of 80 patients with intramural ureter stones were included in the study from December 2007 to November 2009... While our study demonstrated no improvement in expulsion rate, Tolterodine reduced the common symptoms of frequency, urgency, intensity of the pain episodes and discomfort often associated with intramural ureter stone.

Superior efficacy of fesoterodine over tolterodine extended release with rapid onset: a prospective, head-to-head, placebo-controlled trial. [2011.05]
OBJECTIVE: * To show the superior efficacy of fesoterodine over tolterodine extended release (ER) in a placebo-controlled overactive bladder (OAB) trial with predefined treatment comparisons for both diary measures and patient-reported outcomes... CONCLUSIONS: * In this randomized study, which is the largest to compare antimuscarinic efficacy performed to date, fesoterodine 8 mg was superior to tolterodine ER 4 mg for UUI episodes, micturitions and urgency episodes, as well as for self-reported patient assessments of bladder-related problems, urgency, symptom bother and health-related quality of life. * The superiority of fesoterodine 8 mg over tolterodine ER 4 mg was observed as early as 3 weeks after escalation from fesoterodine 4 mg for most outcomes. These data may have important implications for the clinical management of OAB patients previously treated with tolterodine ER. (c) 2010 THE AUTHORS. BJU INTERNATIONAL (c) 2010 BJU INTERNATIONAL.

[Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity]. [2011.04]
OBJECTIVE: To evaluate the efficacy and safety of Tolterodine Tartrate combined with the alpha-receptor blocker in the treatment of benign prostatic hyperplasia with detrusor overactivity (BPH-DO)... CONCLUSION: The combined use of Tolterodine Tartrate and the alpha-receptor blocker can effectively relieve the symptoms of dysuria, urinary frequency and urinary urgency in patients with BPH-DO, with neither significant adverse effects on the maximum flow rate and residual urine volume nor increase in the incidence of acute urinary retention.

The efficacy of additive tolterodine extended release for 1-year in older men with storage symptoms and clinical benign proastatic hyperplasia. [2011.04]
AIM: To determine the efficacy of toterodine extended release (ER) treatment for 1 year in older men with benign prostatic hyperplasia (BPH) and storage symptoms treated with alpha-blockers and/or 5-alpha-reductase inhibitors (5ARI)... CONCLUSIONS: This longer comparative study indicated that additive treatment with tolterodine ER in older men with BPH/BOO and significant storage symptoms is a beneficial and safe therapeutic option. Copyright (c) 2011 Wiley-Liss, Inc.

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Clinical Trials Related to Detrol LA (Tolterodine)

A Study to Evaluate Tolerability and Patient Preference Between Myrbetriq® and Detrol® LA in Subjects With Overactive Bladder (OAB) [Active, not recruiting]
The purpose of this study is to assess tolerability of Myrbetriq compared to Detrol LA in the treatment of subjects with Overactive Bladder (OAB). This study will also assess patient preference, safety and tolerability of Myrbetriq and Detrol LA in subjects with symptoms of OAB as well as the impact of treatment on micturition frequency and incontinence episodes.

Tolterodine Drug Use Investigation.(Post Marketing Commitment Plan) [Completed]
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the Package Insert (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3) factors considered to affect the safety and/or efficacy of this drug.

Dutasteride With Tolterodine ER or Placebo to Treat Lower Urinary Tract Symptoms (LUTS) [Completed]
This is an investigator-initiated study of safety, efficacy and tolerability of dutasteride given for 18 months, including a 1-year double-blind randomized co-administration with either tolterodine ER or placebo in men suffering from lower urinary tract symptoms (LUTS) including urgency and frequency, with or without urgency urinary incontinence (i. e., overactive bladder (OAB) symptoms).

Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects [Completed]
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older

A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause. [Terminated]
This study is being done to compare frequency of urination during the night when women take tolterodine tablets vs. when they take placebo tablets. We will also measure whether between these two treatment conditions there are any differences in women's sleep, mood and performance on cognitive tests.

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Reports of Suspected Detrol LA (Tolterodine) Side Effects

Drug Ineffective (84)DRY Mouth (23)Urinary Incontinence (21)Fall (19)Malaise (17)Bladder Disorder (16)Nocturia (15)Constipation (13)Abdominal Pain Upper (13)Hypoacusis (13)more >>


Based on a total of 6 ratings/reviews, Detrol LA has an overall score of 6.33. The effectiveness score is 7 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Detrol LA review by 40 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   incontinence
Dosage & duration:   2mg taken once day for the period of 5 years
Other conditions:   quadriplegia
Other drugs taken:   oxybuiton, imipramine
Reported Results
Benefits:   stopped my bladder incontinence when used in combination with my other bladder medications on my neurogenic bladder
Side effects:   drowsiness, urinary retention may have caused dry mouth but not as bad as using ditropan does
Comments:   This drug was added as I have very strong bladder spasms. It's side effects are better than ditropan and I would recommend people try it first


Detrol LA review by 56 year old male patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   spasdic bladder
Dosage & duration:   2 mg taken twice a day for the period of 2 years
Other conditions:   Multiple sclerosis
Other drugs taken:   Lyrica
Reported Results
Benefits:   As an RN for 14 years, I was familiar with Detrol LA and why it was prescribed for me. I was diagnosed two years ago with Multiple Sclerosis and have a spastic bladder. Soon after being prescribed Detrol LA, I had a definite decrease in urination frequency. However, after about six months, my urinary habits returned to pre-medication levels. I void every two hours. About one year ago, I stopped taking Detrol LA for two months, thinking that giving my bladder a break from the med would help. I then restarted Detrol LA and noticed no difference. I am seriously thinking about stopping the medication. It is essentially useless.
Side effects:   Mild dry mouth. Otherwise, no side effects.
Comments:   I have been on Detrol LA for since being diagnosed with Multiple Sclerosis two years ago. I have a spastic bladder and urinate every two hours. I take 2mg twice a day. The medicine worked for about six months, then was virtually ineffective.


Detrol LA review by 56 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   Frequent and urgent urination
Dosage & duration:   4mg taken once a day for the period of 4 days
Other conditions:   MS, perioral dermatitis,allergies
Other drugs taken:   amitriptyline,ZyrtecD,Gabapentin,Requip,Baclofen,Veramyst,Copaxone
Reported Results
Benefits:   Gabapentin worked extremely well for my leg neuropathy.A combination of Zyrtec and Veramyst works quite well for my allergies. Requip takes care of my restless legs which at times had me getting up and having to walk to relieve the discomfort. Baclofen helps with my spasticity. After taking amitriptyline I am able to go to sleep in an hour or so. As for the Copaxone who knows? I have had only one flare up since starting it.
Side effects:   The Detrol was horrible. My mouth was so dry my tongue literally stuck to the roof of my mouth making it difficult to speak. The Copaxone causes lumps and itching at the injection site.
Comments:   When Zyrtec alone didn't controll my allergies my doctor prescribed the Veramyst to try. This combination seems to be working, Zyrtec once a day and Veramyst twice daily. The Baclofen 10mg.is taken as needed one to four times a day. Sometimes I'm not bothered with spasticity too often but when I am I take the Baclofen and it works.Amitriptyline tabs 25mg are taken before bedtime.Requip tabs .5mg are taken in the evening. Gabapentin 300mg is taken 3-4 times a day depending on the severity of pain. Tetracycline HCL 250mg is taken once a day. The Copaxone 200mg is injected once a day. I discontinued the Detrol LA as I could not tolerate the extreme dry mouth.

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Page last updated: 2014-11-30

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