Desonide (Desonide Topical) - Summary

DESONIDE SUMMARY

DESONIDE OINTMENT, 0.05%

Desonide Ointment, 0.05% contains microdispersed desonide (the active ingredient) in white petrolatum. Each gram of desonide ointment contains 0.5 milligrams of desonide. Desonide Ointment is applied topically. Desonide is a non-fluorinated corticosteroid.

Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

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NEWS HIGHLIGHTS

Published Studies Related to Desonide (Desonide Topical)

An investigator-blind, randomized, 4-week, parallel-group, multicenter pilot study to compare the safety and efficacy of a nonsteroidal cream (Promiseb Topical Cream) and desonide cream 0.05% in the twice-daily treatment of mild to moderate seborrheic dermatitis of the face. [2009.11]
The treatment of seborrheic dermatitis includes topical antifungal agents to eradicate Malassezia spp, corticosteroids, which treat the inflammatory component of the disease and keratolytics which remove scale and crust. This study compared the efficacy of a nonsteroidal topical cream and a low-potency topical corticosteroid for the treatment of mild to moderate seborrheic dermatitis of the face in 77 volunteers randomized to twice-daily treatment with nonsteroidal cream or corticosteroid cream for up to 28 days...

Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis. [2007.02]
Low to mid potency corticosteroids remain a cornerstone of therapy for atopic dermatitis (AD)...

Corneofungimetry bioassay on Malassezia spp. under ketoconazole and desonide influences. [2005.03]
CONCLUSION: The presence of 0.05% desonide does not impair or improve the Malassezia susceptibility to 2% ketoconazole when growing on lipid-enriched human stratum corneum. Copyright 2005 S. Karger AG, Basel.

Self-reported participant experience with desonide hydrogel in the treatment of mild to moderate atopic dermatitis. [2011.07]
The objective of this study was to evaluate patients' real-world experiences with desonide hydrogel for the treatment of mild to moderate atopic dermatitis (AD). Physicians who participated in this patient-experience program identified eligible participants (age range, < 3 months to 91 years) for treatment with desonide hydrogel 0.05%...

Good adherence and early efficacy using desonide hydrogel for atopic dermatitis: results from a program addressing patient compliance. [2010.04]
BACKGROUND: Patients with atopic dermatitis (AD) may have poor adherence for several reasons, including fear of side effects or dislike of messy topical therapies. PURPOSE: To assess adherence to and efficacy of a multifaceted program for atopic dermatitis using a lightweight, easy-to-apply medication and more frequent return visits... CONCLUSION: Subjects responded very well to treatment, and adherence to desonide hydrogel 0.05% was much better than previously reported with ointments. The early efficacy, favorable attributes of the hydrogel vehicle and judicious follow up likely increased adherence to topical therapy. The use of ointments or more potent topical steroids as a first choice may be counterproductive in the treatment of atopic dermatitis.

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Clinical Trials Related to Desonide (Desonide Topical)

Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis [Active, not recruiting]
The purpose of this research study is to better understand how this study drug works when people use it to treat atopic dermatitis. Desonate has been approved by the US Food and Drug Administration (FDA) for atopic dermatitis.

Efficacy Emollient on Xerosis in Children With Atopic Dermatitis [Recruiting]
Atopic dermatitis is a frequent, chronic inflammatory disease influenced by local, immunological, genetic and environmental factors. Important symptoms of atopic dermatitis are dry skin, intense pruritus and impaired epidermal barrier function. Atopic dermatitis is associated with skin barrier dysfunction that facilitates an easier allergen penetration into the skin with an increased irritation and subsequent cutaneous inflammation. A lack of important stratum corneum intercellular lipids and an inadequate ratio between compounds enhance trans-epidermal water loss leading to xerosis. Skin hydration by emollient therapy usually twice daily improves dryness and subsequently pruritus during the treatment of atopic dermatitis and especially improves the barrier function. Emollients make part of basic therapy (grade 1) for treatment of atopic dermatitis (European Academy of Dermatology and Venereology Task Force 2009 Position Paper). Improvement of cutaneous barrier alteration, measured by skin hydration, is a key element for evaluation of emollient treatment efficacy.

The primary objective of this study is to demonstrate the efficacy of the tested product (V0034CR01B) cream on xerosis in children with atopic dermatitis compared to the excipient formula during 28 days.

Comparison of the Efficacy and Safety of Two Topical Creams for Pediatric Atopic Dermatitis [Not yet recruiting]
This study compares the effectiveness of two topical creams for atopic dermatitis in pediatric subjects. Subjects will be randomly assigned to use one of the two creams twice daily for 6 weeks or until clear.

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PATIENT REVIEWS / RATINGS / COMMENTS

Desonide review by 29 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		exzema of the face
Dosage & duration:		0.05% (dosage frequency: up to three times daily) for the period of up to 6 months
Other conditions:		none. just skin irritations
Other drugs taken:		none
		Reported Results
Benefits:		the treatment benefits was that the skin irritation did go away for awhile. I thought that I had been cured of the skin rash. It cleared my skin up and gave me relief from the rash.
Side effects:		It turns out it did not cure it at all but possibly hurt my face. It also may have made the condition spread to other areas of my face because in time I had other areas of my face where the rash was. The cream was only a temporary relief to a deeper situation. If one is looking for fast relief it will help but it covers up an initial problem that needs to be addressed.
Comments:		I saw a few dermatologists and each one told me to use it twice daily. I was even given different forms. One a cream and the other a foam. I was also informed to use them for two weeks and then stop. I did, and when I stopped my rash slowly started coming back.