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Desmopressin (Desmopressin Acetate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS:

Infrequently, large doses of the intranasal formulations of desmopressin acetate and desmopressin acetate injection have produced transient headache, nausea, flushing and mild abdominal cramps. These symptoms have disappeared with reduction in dosage.

Central Diabetes Insipidus:

In long-term clinical studies in which patients with diabetes insipidus were followed for periods up to 44 months of desmopressin acetate tablet therapy, transient increases in AST (SGOT) no higher than 1.5 times the upper limit of normal were occasionally observed. Elevated AST (SGOT) returned to the normal range despite continued use of desmopressin acetate tablets.

Primary Nocturnal Enuresis:

The only adverse event occurring in ≥ 3% of patients in controlled clinical trials with desmopressin acetate tablets that was probably, possibly, or remotely related to study drug was headache (4% desmopressin acetate, 3% placebo).

Other:

The following adverse events have been reported; however, their relationship to desmopressin acetate has not been established: abnormal thinking, diarrhea, and edema-weight gain.

See WARNINGS for the possibility of water intoxication and hyponatremia.



REPORTS OF SUSPECTED DESMOPRESSIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Desmopressin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Desmopressin side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-05

Patient: 43 year old male weighing 104.1 kg (229.0 pounds)

Reactions: Product Container Seal Issue

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Desmopressin
    Dosage: 1 sprays in each nostril twice daily
    Indication: Renal Failure
    Start date: 2011-10-04

Desmopressin
    Dosage: 1 sprays in each nostril twice daily
    Indication: Hypopituitarism
    Start date: 2011-10-04



Possible Desmopressin side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-06

Patient: 43 year old male weighing 104.1 kg (229.0 pounds)

Reactions: Fear, Device Physical Property Issue

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Desmopressin
    Dosage: 1 sprays in each nostriltwicedaily
    Indication: Renal Failure
    Start date: 2011-10-04

Desmopressin
    Dosage: 1 sprays in each nostriltwicedaily
    Indication: Hypopituitarism
    Start date: 2011-10-04



Possible Desmopressin side effects / adverse reactions in 27 year old female

Reported by a physician from Netherlands on 2011-10-10

Patient: 27 year old female

Reactions: Arterial Thrombosis, Intestinal Ischaemia, Overdose, Gallbladder Disorder

Adverse event resulted in: hospitalization

Suspect drug(s):
Desmopressin



See index of all Desmopressin side effect reports >>

Drug label data at the top of this Page last updated: 2013-01-18

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