Desmopressin (Desmopressin Acetate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Infrequently, desmopressin acetate has produced transient headache, nausea, mild abdominal cramps and vulval pain. These symptoms disappeared with reduction in dosage. Occasionally, injection of desmopressin acetate has produced local erythema, swelling or burning pain. Occasional facial flushing has been reported with the administration of desmopressin acetate. Desmopressin Acetate Injection has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall and a compensatory increase in heart rate. Severe allergic reactions including anaphylaxis have been reported rarely with Desmopressin Acetate Injection.

See WARNINGS for the possibility of water intoxication and hyponatremia.

There have been rare reports of thrombotic events (acute cerebrovascular thrombosis, acute myocardial infarction) following Desmopressin Acetate Injection in patients predisposed to thrombus formation.

REPORTS OF SUSPECTED DESMOPRESSIN SIDE EFFECTS / ADVERSE REACTIONS

Possible Desmopressin side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-05

Patient: 43 year old male weighing 104.1 kg (229.0 pounds)

Reactions: Product Container Seal Issue

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Desmopressin
    Dosage: 1 sprays in each nostril twice daily
    Indication: Renal Failure
    Start date: 2011-10-04

Desmopressin
    Dosage: 1 sprays in each nostril twice daily
    Indication: Hypopituitarism
    Start date: 2011-10-04

Possible Desmopressin side effects / adverse reactions in 43 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-06

Patient: 43 year old male weighing 104.1 kg (229.0 pounds)

Reactions: Fear, Device Physical Property Issue

Adverse event resulted in: life threatening event, disablity

Suspect drug(s):
Desmopressin
    Dosage: 1 sprays in each nostriltwicedaily
    Indication: Renal Failure
    Start date: 2011-10-04

Desmopressin
    Dosage: 1 sprays in each nostriltwicedaily
    Indication: Hypopituitarism
    Start date: 2011-10-04

Possible Desmopressin side effects / adverse reactions in 27 year old female

Reported by a physician from Netherlands on 2011-10-10

Patient: 27 year old female

Reactions: Arterial Thrombosis, Intestinal Ischaemia, Overdose, Gallbladder Disorder

Adverse event resulted in: hospitalization

Suspect drug(s):
Desmopressin