Desferal, deferoxamine mesylate USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration.
Desferal is indicated for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias.
Desferal is an adjunct to, and not a substitute for, standard measures used in treating acute iron intoxication, which may include the following: induction of emesis with syrup of ipecac; gastric lavage; suction and maintenance of a clear airway; control of shock with intravenous fluids, blood, oxygen, and vasopressors; and correction of acidosis.
Desferal can promote iron excretion in patients with secondary iron overload from multiple transfusions (as may occur in the treatment of some chronic anemias, including thalassemia). Long-term therapy with Desferal slows accumulation of hepatic iron and retards or eliminates progression of hepatic fibrosis.
Iron mobilization with Desferal is relatively poor in patients under the age of 3 years with relatively little iron overload. The drug should ordinarily not be given to such patients unless significant iron mobilization (e.g., 1 mg or more of iron per day) can be demonstrated.
Desferal is not indicated for the treatment of primary hemochromatosis, since phlebotomy is the method of choice for removing excess iron in this disorder.
Published Studies Related to Desferal (Deferoxamine)
The Effects of N-Acetylcysteine and Deferoxamine on Plasma Cytokine and Oxidative Damage Parameters in Critically Ill Patients With Prolonged Hypotension: A Randomized Controlled Trial. [2011.11.01]
Reactive oxygen species and inflammation have been implicated in renal tubule cell injury. However, there is some controversy concerning whether antioxidants might attenuate oxidative damage and inflammation in humans after hypotension in the setting of critical illness... NAC plus DFX administration was able to decrease plasma markers of oxidative damage and creatinine levels at hospital discharge.
Sequential alternating deferiprone and deferoxamine treatment compared to deferiprone monotherapy: main findings and clinical follow-up of a large multicenter randomized clinical trial in -thalassemia major patients. 
In beta-thalassemia major (beta-TM) patients, iron chelation therapy is mandatory to reduce iron overload secondary to transfusions.These data suggest that alternating sequential L1-DFO treatment may be useful for some beta-TM patients who may not be able to receive other forms of chelation treatment.
The effects of deferoxamine mesylate on iron elimination after blood transfusion in neonatal foals. [2010.11]
BACKGROUND: Hepatic failure is one of the more common complications in foals requiring blood transfusion to treat neonatal isoerythrolysis.
Comparison of low-dose deferoxamine versus standard-dose deferoxamine for treatment of aluminium overload among haemodialysis patients. [2010.05]
BACKGROUND: Patients on maintenance haemodialysis are at high risk of aluminium overload. While deferoxamine (DFO) has potential adverse effects, lower DFO dosages may afford good efficacy with fewer side effects. We evaluated the therapeutic response of low-dose (2.5 mg/kg/week) DFO among haemodialysis patients with aluminium overload... CONCLUSIONS: Low-dose DFO may offer similar therapeutic effects as standard-dose DFO therapy.
Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. [2009.04]
A multicentre randomized open-label trial was designed to assess the effectiveness of long-term sequential deferiprone-deferoxamine (DFO-DFP) versus DFP alone to treat thalassaemia major (TM). DFP at 75 mg/kg, divided into three oral daily doses, for 4 d/week and DFO by subcutaneous infusion (8-12 h) at 50 mg/kg per day for the remaining 3 d/week was compared with DFP alone at 75 mg/kg, administered 7 d/week during a 5-year follow-up...
Clinical Trials Related to Desferal (Deferoxamine)
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion [Recruiting]
Iron overload has been associated with greater brain injury in ischemia/reperfusion
experimental stroke models and ischemic stroke patients, especially in those treated with
thrombolytic treatment. Deferoxamine administration, an iron chelator, offers a
neuroprotective action in ischemia/reperfusion animal models.
Primary objective: To evaluate the security and tolerability of deferoxamine endovenous
treatment in acute ischemic stroke patients treated with iv. tPA.
Secondary objectives: To study pharmacokinetics of deferoxamine given by endovenous bolus
(10 mg/Kg) followed by 72-hour continuous intravenous infusion (20, 40 o 60 mg/Kg). To
evaluate the deferoxamine effect in clinical outcome, infarct volume and hemorrhagic
transformation and brain edema development.
Methodology: Double-blind, randomized, placebo controlled, dose-finding phase II clinical
trial. Study stages: 1st: bolus+20 mg/Kg/day vs. Placebo (n=15: 5); 2nd: bolus+40 mg/Kg/day
vs. Placebo (n=15: 5); 3rd: bolus+60 mg/Kg/day vs placebo (n=15: 5). These doses will be
increased according to security results of the previous stage. Patients will be continuously
monitored in stroke units. Laboratory parameters will be measured at baseline, 24h, 72h and
30 days to evaluate adverse events related to the drug. Serum deferoxamine and feroxamine
concentrations will be measured along time after the injection in a subgroup of patients to
the pharmacokinetics study. CT scan will be performed at 24-36h to assess hemorrhagic
transformation and brain edema. The NIH Stroke Scale will be evaluated during
hospitalization, and the Rankin score at discharge and 3 months.
If deferoxamine demonstrate to be secure and well tolerated treatment in acute stroke
patients, it may be a new therapy option to lower the brain injury after ischemia and
Iron Balance Study of Deferasirox, Deferoxamine and the Combination of Both [Recruiting]
Subjects with thalassemia major require regular transfusion therapy to sustain life. The
iron present in the transfused blood remains in the body where it can cause a variety of
organ dysfunctions. Lifelong iron chelation therapy is needed to maintain iron balance but
its effectiveness varies greatly. Like that of deferoxamine (Desferal, DFO) the mainstay of
chelation therapy for 30 years, the effectiveness of deferasirox (Exjade, ICL670), the newly
approved, orally effective iron chelating drug, is not satisfactory in all subjects. Even
with good compliance, the iron excretion induced by a given drug exhibits wide
subject-to-subject variability. There is often persistent iron overload of extra hepatic
tissues such as the heart and pancreas leading to cardiac disease and diabetes. Combining
the drugs may be a better approach in those subjects at increased risk. The iron balance
studies proposed will permit an assessment of the potential of such a combination to place
subjects in net negative iron balance and the relative effectiveness of the combination in
relation to that of the individual drugs, an additive effect being expected. With such
information, physicians will be able to design individualized chelation regimens that
maximize effectiveness while minimizing side effects by adjusting the ratio and/or the
dosing schedule of the two drugs.
Combo Chelation Trial [Recruiting]
This is a small pilot study looking at the safety of giving combination chelation with
Exjade and Desferal to 15 patients. The hypothesis is that combination chelation is safe in
decreasing overall iron in patients with thalassemia.
High-Dose Deferoxamine in Intracerebral Hemorrhage [Not yet recruiting]
The main purpose of this study is to determine whether treatment with deferoxamine mesylate
is of sufficient promise to improve outcome before pursuing a larger clinical trial to
examine its effectiveness as a treatment for brain hemorrhage.
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload [Recruiting]
This is a clinical research study in patients who have iron overload in the heart due to
chronic blood transfusions.
The study will have 2 treatment groups and will compare the safety and efficacy of chelation
therapy with a medicine called deferasirox (ICL670) with another medicine called
deferoxamine (DFO). The study is aimed at finding out which of the two medicines is the best
for treating iron overload in the heart.
Patients will be treated for 12 months (core study phase). Patients who complete the core
study phase will be offered to continue their study treatment in a 12 months extension
phase. During the core and extension, the effects of treatment on iron overload in the heart
and the liver will be evaluated using specific magnetic resonance imaging (MRI) assessments.
Reports of Suspected Desferal (Deferoxamine) Side Effects
Serum Ferritin Increased (7),
Oedema Peripheral (5), more >>