NEWS HIGHLIGHTSMedia Articles Related to Dermatop ( Topical)
Basilea's Toctino(R) Receives Marketing Authorization In Canada
Source: Dermatology News From Medical News Today [2009.11.18]
Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. "We are delighted that Health Canada has approved the use of Toctino for patients with severe chronic hand eczema unresponsive to potent topical steroids.
Sol-Gel's IND Application For Rosacea Accepted By FDA
Source: Dermatology News From Medical News Today [2009.11.12]
Sol-Gel Technologies announced that the U.S. Food and Drug Administration (FDA) has acknowledged receipt of Sol-Gel's Investigational New Drug Application (IND) for DER45-EV Gel for the topical treatment of rosacea. This IND allows Sol-Gel to initiate Phase II studies with DER45-EV Gel in rosacea patients. DER45-EV Gel is an innovative topical product based on Sol-Gel's patented drug delivery system that is designed to enhance the efficacy, safety and stability of topical drugs.
EADV: Systemic Psoriasis Therapy Often Delayed (CME/CE)
Source: MedPage Today Dermatology [2009.10.12]
BERLIN (MedPage Today) -- Patients with psoriasis resistant to topical therapy frequently wait a year or longer to receive systemic therapy, investigators reported here.
Topical Erectile Dysfunction Therapy Shows Promise
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2009.09.19]
An innovative drug-delivery system nanoparticles encapsulating nitric oxide or prescription drugs shows promise for topical treatment of erectile dysfunction (ED), according to a new study by scientists at Albert Einstein College of Medicine of Yeshiva University. The new system, tested successfully on a small number of animals, could potentially prevent side effects associated with oral ED medications, if study results can be replicated in humans.
Published Studies Related to Dermatop ( Topical)
Topical imiquimod in conjunction with Nd:YAG laser for tattoo removal. [2009.11]
The purpose of this study is to evaluate the efficacy of tattoo removal using topical imiquimod 5% cream in conjunction with the 1,064-nm Nd:YAG laser. This procedure for tattoo removal will be compared to laser treatment alone, which is the standard for cosmetic removal of tattoos...
Quality of Life Improvements Attributed to Combination Therapy with Oral and Topical Mesalazine in Mild-to-Moderately Active Ulcerative Colitis. [2009.10.15]
Background/Aim: To investigate patient-reported health-related quality of life (HRQoL) in data collected from a multinational randomized double-blind controlled trial comparing oral mesalazine (4 g) + topical mesalazine enema (1 g) to oral mesalazine alone (4 g)...
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. [2009.10]
Objective: To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure...
Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata. [2009.10]
BACKGROUND: Alopecia areata, hair loss caused by perifollicular T-cell infiltrates, is refractory to therapy. Bexarotene, a retinoid X receptor is a selective retinoid, induces T-cell apoptosis. OBJECTIVE: We sought to determine the safety, including the dose-limiting toxicities with adverse events, and efficacy, ie, response rate, of bexarotene in alopecia areata... CONCLUSION: Topical bexarotene 1% application is well tolerated and possibly effective. A randomized placebo-controlled trial should be conducted.
Tolerability of high-dose topical tretinoin: the Veterans Affairs Topical Tretinoin Chemoprevention Trial. [2009.10]
BACKGROUND: Topical tretinoin is a medication commonly used for acne that has potential application in the long-term treatment of photodamaged skin. However, there are few published data regarding the tolerability of high-dose tretinoin with long-term use. OBJECTIVES: To assess the long-term tolerability of tretinoin 0.1% cream... CONCLUSIONS: Overall, the tolerability level of topical tretinoin was high in this study population, with almost 40% of the tretinoin group reporting no side-effects, and the majority (67%) tolerating at least once-daily dosing at 6-month follow-up. High-dose topical tretinoin is feasible for long-term use in this population.
Clinical Trials Related to Dermatop ( Topical)
Standardized Time- and Score-Oriented Treatment of Moderate and Severe Atopic Dermatitis [Completed]
The study was designed to test the hypothesis whether a standardized, time-and score-oriented
treatment following a strict evidence based algorithm is equally effective to a standard
treatment regimen for moderate to severe atopic dermatitis.
Study Type: Mono-centre study, patients are blinded, physicians are randomized to either
treat study- or controll group
Eligible are patients age 2 years or older with SCORAD >= 20 Duration: 12 Months, study
visits every 4 weeks.
Primary endpoint is Difference between Baseline SCORAD and mean SCORAD under treatment.
Secundary endpoints are quality of life, safety and economic burden in both treatment
groups.
Fexofenadine in Pruritic Skin Disease [Completed]
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