Media Articles Related to Depodur (Morphine Epidural)
More resilient people tend to have a higher pain tolerance
Source: Anxiety / Stress News From Medical News Today [2014.09.13]
Resilience, a person's ability to overcome adverse circumstances, is the main quality associated with pain tolerance among patients and their adjustment to chronic pain.
Avoiding Pain Management Prosecutions
Source: Medscape NeurologyHeadlines [2014.09.12]
The key to staying out of court, says an attorney with years of experience in the field, is keeping up-to-date documentation.
Medscape Medical News
International Conference and Exhibition on Pain Medicine, June 08-10, 2015, Chicago
Source: Conferences News From Medical News Today [2014.09.12]
OMICS Group is pleased to invite you to participate in the International Conference and Exhibition on Pain Medicine during June 08-10, 2015 at Chicago, USA.
Groundbreaking study reveals best positions for sex for men who have back pain
Source: Sexual Health / STDs News From Medical News Today [2014.09.12]
Contrary to popular belief, spooning is not always the best sex position for those with a bad back, according to new research from the University of Waterloo.
OncoBriefs: New Myeloma Standard? Robotics and Pain (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2014.09.12]
(MedPage Today) -- Patients with newly diagnosed multiple myeloma lived longer and had significantly slower disease progression with a new two-drug regimen than with a long-time, standard three-drug regimen, a randomized trial showed.
Published Studies Related to Depodur (Morphine Epidural)
Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...
Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.
A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. [2011.05]
OBJECTIVE: To compare post-operative motor function in dogs that received epidural morphine and low dose bupivacaine versus epidural morphine alone following splenectomy... This combination can be used without concern of motor paralysis in healthy animals.
Higher postoperative pain and increased morphine consumption follow pre- rather than post-incisional single dose epidural morphine. [2011.04]
BACKGROUND: Neuraxial administration of morphine is an effective way of controlling postoperative pain and reducing analgesic consumption. Some animal models have demonstrated that preemptive administration of neuraxial narcotics reduces pain, while others have revealed the contrary. In addition, there have been no consistent results in clinical settings. This double-blind, randomized study compared the effects of pre- vs. post-incisional administration of neuraxial morphine on postoperative pain perception and analgesic requirements over 48 hours following laparotomy for open colectomy under standardized general anesthesia... CONCLUSION: Pre-incisional epidural morphine in patients undergoing open colonic surgery under general anesthesia was associated with more postoperative pain, a greater need for analgesics, and poorer patient satisfaction compared to post-incisional morphine administration.
Analgesia and pulmonary function after lung surgery: is a single intercostal nerve block plus patient-controlled intravenous morphine as effective as patient-controlled epidural anaesthesia? A randomized non-inferiority clinical trial. [2011.04]
BACKGROUND: Thoracic epidural anaesthesia (EDA) is regarded as the 'gold standard' for postoperative pain control and restoration of pulmonary function after lung surgery. Easier, less time-consuming, and, perhaps, safer is intercostal nerve block performed under direct vision by the surgeon before closure of the thoracotomy combined with postoperative i.v. patient-controlled analgesia with morphine. We hypothesized that this technique is as effective as thoracic EDA... CONCLUSIONS: In patients undergoing lung surgery, single intercostal nerve block plus i.v. patient-controlled analgesia with morphine is not as effective as patient-controlled EDA with respect to pain control and restoration of pulmonary function.
Clinical Trials Related to Depodur (Morphine Epidural)
Depodur vs Fentanyl Infusion for Post-C/S Analgesia [Not yet recruiting]
Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement [Recruiting]
The investigators hypothesize that patients who receive a femoral catheter with low dose
epidural Depodur will experience comparable or superior pain relief than those who receive
both femoral and sciatic catheters. In addition, the investigators hypothesize that the one
catheter will be less time consuming to place and facilitate early ambulation of the
Clinical Study of Depodur Efficacy in Decreasing Post Operative Pain After Off Pump Coronary Artery Bypass Grafting (OP-CABG) [Not yet recruiting]
The purpose of this study is to determine whether epidural Depodur alleviates the pain of
OP-CABG surgery. This includes pain associated with sternotomy, retraction, dissection and
other tissue insults, as well as the induced inflammatory system and effects from prolonged
ventilation in the ICU setting.
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children [Recruiting]
The purpose of this proposal is to improve the investigators' current Selective Dorsal
Rhizotomy (SDR) analgesia protocol by eliminating or minimizing the use of fentanyl in the
Children undergoing SDR for spastic cerebral palsy have significant post-operative pain.
The procedure requires dissection of the lumbar back musculature and removal of the L1
lamina (the bony posterior part of the vertebra). The majority of the operation is
intradural, and a water-tight dural closure at the termination of the operation is critical
in order to prevent leakage of cerebrospinal fluid (CSF) from the wound. In fact, these
children must remain flat on their back for 48 hours to allow the dural incision to heal
prior to mobilization. Thus, adequate pain control is essential not only for patient
comfort, but also to prevent agitation and additional stress on the dural closure.
Currently, the investigators' patients undergoing SDR are treated for 48 hours with
scheduled intravenous (IV) narcotic (continuous fentanyl infusion at 0. 5-2. 0 μg/kg/hour) in
addition to the sedative/muscle relaxant Valium (0. 2 mg/kg IV every 4 hours for 24 hours,
then every 6 hours for 24 hours). The IV fentanyl, and to a lesser degree Valium, carries a
real risk of hypotension and respiratory depression and requires frequent dose adjustments
to achieve adequate analgesia.
By improving the current SDR analgesia protocol, the investigators hope to maximize patient
safety and comfort while maintaining the effectiveness of the operation by minimizing the
risk of CSF leak.