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Depodur (Morphine Sulfate Epidural) - Summary



(morphine sulfate extended-release liposome injection)
Rx Only

DepoDur (morphine sulfate extended-release liposome injection) is a sterile suspension of multivesicular liposomes containing morphine sulfate, intended for epidural administration.

DepoDur (morphine EPIDURAL) is indicated for the following:

DepoDur is an extended-release liposome injection of morphine sulfate intended for single-dose administration by the epidural route, at the lumbar level, for the treatment of pain following major surgery. DepoDur is administered prior to surgery or after clamping the umbilical cord during cesarean section.

DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended.

See all Depodur indications & dosage >>


Media Articles Related to Depodur (Morphine Epidural)

Medical News Today: Going through a breakup? The placebo effect might ease your pain
Source: Featured Health News from Medical News Today [2017.04.29]
Researchers reveal how a placebo nasal spray helped to reduce emotional pain for adults who had recently broken up with their partner.

Going through a breakup? The placebo effect might ease your pain
Source: Psychology / Psychiatry News From Medical News Today [2017.04.29]
Researchers reveal how a placebo nasal spray helped to reduce emotional pain for adults who had recently broken up with their partner.

MRI Connects the Dots in Back Pain (CME/CE)
Source: MedPage Today Rheumatology [2017.04.28]
(MedPage Today) -- Results suggest specific pain pattern induced by axial inflammation

Did Syphilis Cause Painter Goya's Hearing Loss?
Source: MedicineNet Deafness Specialty [2017.04.28]
Title: Did Syphilis Cause Painter Goya's Hearing Loss?
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 4/28/2017 12:00:00 AM

Development of an Internet-Based Chronic Pain Intervention
Source: Medscape Anesthesiology Headlines [2017.04.27]
What benefits could this new internet-based intervention offer patients suffering from chronic pain?
Pain Management Nursing

more news >>

Published Studies Related to Depodur (Morphine Epidural)

Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery. [2014]
DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery...

Transversus abdominis plane block versus perioperative intravenous lidocaine versus patient-controlled intravenous morphine for postoperative pain control after laparoscopic colorectal surgery: study protocol for a prospective, randomized, double-blind controlled clinical trial. [2014]
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal surgery, postoperative pain management for minimally invasive surgery is still mainly based on strategies that have been established for open surgical procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative pain management, we aim to investigate whether a transversus abdominis plane block delivers superior pain control in comparison to perioperative intravenous lidocaine and patient-controlled intravenous analgesia with morphine alone.

Transversus abdominis plane block reduces morphine consumption in the early postoperative period following microsurgical abdominal tissue breast reconstruction: a double-blind, placebo-controlled, randomized trial. [2014]
in a randomized controlled trial... CONCLUSION: Following abdominally based breast reconstruction, transversus

Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...

Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.

more studies >>

Clinical Trials Related to Depodur (Morphine Epidural)

Safety and Efficacy of DepoDur in Lumbar Spine Surgery Patients [Completed]
The purpose of the study is to help determine the appropriate dose of DepoDur for use in spinal surgery. The study will also assess the safety of this drug in this patient population.

Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur´┐Ż After Cesarean Delivery [Completed]
The purpose of this study is to evaluate the levels of morphine in a patients blood when morphine is given into the epidural space in the form of DepoDur« either alone or following a dose of lidocaine also given in the epidural space. Specifically, we are looking at pregnant women undergoing cesarean delivery who will be receiving these medications. A secondary objective is to evaluate the how well DepoDur« works for pain control, as well as its safety, when it is given either alone or following a dose of epidural lidocaine.

Clinical Study of Depodur Efficacy in Decreasing Post Operative Pain After Off Pump Coronary Artery Bypass Grafting (OP-CABG) [Withdrawn]
The purpose of this study is to determine whether epidural Depodur alleviates the pain of OP-CABG surgery. This includes pain associated with sternotomy, retraction, dissection and other tissue insults, as well as the induced inflammatory system and effects from prolonged ventilation in the ICU setting.

Depodur vs Fentanyl Infusion for Post-C/S Analgesia [Not yet recruiting]

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement [Recruiting]
The investigators hypothesize that patients who receive a femoral catheter with low dose epidural Depodur will experience comparable or superior pain relief than those who receive both femoral and sciatic catheters. In addition, the investigators hypothesize that the one catheter will be less time consuming to place and facilitate early ambulation of the patient.

more trials >>

Page last updated: 2017-04-29

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