(morphine sulfate extended-release liposome injection)
DepoDur (morphine sulfate extended-release liposome injection) is a sterile suspension of multivesicular liposomes containing morphine sulfate, intended for epidural administration.
DepoDur (morphine EPIDURAL) is indicated for the following:
DepoDur is an extended-release liposome injection of morphine sulfate intended for single-dose administration by the epidural route, at the lumbar level, for the treatment of pain following major surgery. DepoDur is administered prior to surgery or after clamping the umbilical cord during cesarean section.
DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended.
Media Articles Related to Depodur (Morphine Epidural)
Chest pain: New tool helps doctors decide when tests are needed
Source: Cardiovascular / Cardiology News From Medical News Today [2017.02.17]
A two year follow-up on a study involving more than 10,000 people with stable chest pain finds that an online tool can accurately predict which patients are likely to have normal non-invasive tests...
Survey Data Paint Picture of PCMH Docs
Source: MedPage Today Public Health & Policy [2017.02.17]
(MedPage Today) -- More support staff, better access to patients' medical records
Spinal Manipulation for Back and Neck Pain: Does It Work?
Source: Medscape Anesthesiology Headlines [2017.02.15]
For decades, osteopathic physicians and chiropractors, who sought to relieve patients' back and neck pain with spinal manipulation, were accused of being quacks. But mounting evidence supports it.
New Reports Paint Mixed Picture of State Telemedicine Laws
Source: Medscape Business of Medicine Headlines [2017.02.14]
State laws increasingly support telemedicine, but change has been slow; all 50 state Medicaid programs now cover virtual visits.
Medscape Medical News
New clinical guideline issued for treating low back pain
Source: Clinical Trials / Drug Trials News From Medical News Today [2017.02.14]
The American College of Physicians have just issued their clinical practice guideline for the noninvasive treatment of nonradicular low back pain.
Published Studies Related to Depodur (Morphine Epidural)
Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery. 
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery...
Transversus abdominis plane block versus perioperative intravenous lidocaine
versus patient-controlled intravenous morphine for postoperative pain control
after laparoscopic colorectal surgery: study protocol for a prospective,
randomized, double-blind controlled clinical trial. 
BACKGROUND: Despite the laparoscopic approach becoming the standard in colorectal
surgery, postoperative pain management for minimally invasive surgery is still
mainly based on strategies that have been established for open surgical
procedures... DISCUSSION: Recognizing the importance of a multimodal approach for perioperative
pain management, we aim to investigate whether a transversus abdominis plane
block delivers superior pain control in comparison to perioperative intravenous
lidocaine and patient-controlled intravenous analgesia with morphine alone.
Transversus abdominis plane block reduces morphine consumption in the early
postoperative period following microsurgical abdominal tissue breast
reconstruction: a double-blind, placebo-controlled, randomized trial. 
in a randomized controlled trial... CONCLUSION: Following abdominally based breast reconstruction, transversus
Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...
Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.
Clinical Trials Related to Depodur (Morphine Epidural)
Safety and Efficacy of DepoDur in Lumbar Spine Surgery Patients [Completed]
The purpose of the study is to help determine the appropriate dose of DepoDur for use in
spinal surgery. The study will also assess the safety of this drug in this patient
Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur´┐Ż After Cesarean Delivery [Completed]
The purpose of this study is to evaluate the levels of morphine in a patients blood when
morphine is given into the epidural space in the form of DepoDur« either alone or following
a dose of lidocaine also given in the epidural space. Specifically, we are looking at
pregnant women undergoing cesarean delivery who will be receiving these medications. A
secondary objective is to evaluate the how well DepoDur« works for pain control, as well as
its safety, when it is given either alone or following a dose of epidural lidocaine.
Clinical Study of Depodur Efficacy in Decreasing Post Operative Pain After Off Pump Coronary Artery Bypass Grafting (OP-CABG) [Withdrawn]
The purpose of this study is to determine whether epidural Depodur alleviates the pain of
OP-CABG surgery. This includes pain associated with sternotomy, retraction, dissection and
other tissue insults, as well as the induced inflammatory system and effects from prolonged
ventilation in the ICU setting.
Depodur vs Fentanyl Infusion for Post-C/S Analgesia [Not yet recruiting]
Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement [Recruiting]
The investigators hypothesize that patients who receive a femoral catheter with low dose
epidural Depodur will experience comparable or superior pain relief than those who receive
both femoral and sciatic catheters. In addition, the investigators hypothesize that the one
catheter will be less time consuming to place and facilitate early ambulation of the