Media Articles Related to Depodur (Morphine Epidural)
Temple study suggests a novel approach for treating non-cardiac chest pain
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2014.10.24]
Chest pain doesn't necessarily come from the heart. An estimated 200,000 Americans each year experience non-cardiac chest pain, which in addition to pain can involve painful swallowing, discomfort...
Extra-Depth Shoes May Help Ease Foot Pain in Elderly
Source: Medscape NeurologyHeadlines [2014.10.23]
For seniors with disabling foot pain, off-the-shelf extra-depth footwear reduced pain and improved function in a new study.
Reuters Health Information
Changing how primary-care doctors treat pain, fatigue and other common symptoms
Source: Pain / Anesthetics News From Medical News Today [2014.10.23]
Common symptoms such as pain or fatigue account for over half of all doctor's office appointments in the United States, translating into more than 400 million visits annually.
Health Tip: Coping With Chronic Pain
Source: MedicineNet Chronic Pain Specialty [2014.10.23]
Title: Health Tip: Coping With Chronic Pain
Category: Health News
Created: 10/23/2014 12:00:00 AM
Last Editorial Review: 10/23/2014 12:00:00 AM
Tear duct implant effective at reducing pain and inflammation in cataract surgery patients
Source: Eye Health / Blindness News From Medical News Today [2014.10.21]
The first tear duct implant developed to treat inflammation and pain following cataract surgery has been shown to be a reliable alternative to medicated eye drops, which are the current standard of...
Published Studies Related to Depodur (Morphine Epidural)
Ropivacaine Continuous Wound Infusion Versus Epidural Morphine for Postoperative Analgesia After Cesarean Delivery: A Randomized Controlled Trial. [2011.10.24]
Background:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia.Methods:Healthy, term women scheduled for elective cesarean delivery were included in this assessor-blinded, randomized study...
Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur(R)) after cesarean delivery. [2011.08]
BACKGROUND: A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM... CONCLUSION: A large dose of epidural lidocaine 1 hour before EREM administration alters the pharmacokinetics and drug effects of EREM. Clinicians must apply caution when EREM is administered even 1 hour after an epidural lidocaine "top-up" for cesarean delivery.
A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. [2011.05]
OBJECTIVE: To compare post-operative motor function in dogs that received epidural morphine and low dose bupivacaine versus epidural morphine alone following splenectomy... This combination can be used without concern of motor paralysis in healthy animals.
Higher postoperative pain and increased morphine consumption follow pre- rather than post-incisional single dose epidural morphine. [2011.04]
BACKGROUND: Neuraxial administration of morphine is an effective way of controlling postoperative pain and reducing analgesic consumption. Some animal models have demonstrated that preemptive administration of neuraxial narcotics reduces pain, while others have revealed the contrary. In addition, there have been no consistent results in clinical settings. This double-blind, randomized study compared the effects of pre- vs. post-incisional administration of neuraxial morphine on postoperative pain perception and analgesic requirements over 48 hours following laparotomy for open colectomy under standardized general anesthesia... CONCLUSION: Pre-incisional epidural morphine in patients undergoing open colonic surgery under general anesthesia was associated with more postoperative pain, a greater need for analgesics, and poorer patient satisfaction compared to post-incisional morphine administration.
Analgesia and pulmonary function after lung surgery: is a single intercostal nerve block plus patient-controlled intravenous morphine as effective as patient-controlled epidural anaesthesia? A randomized non-inferiority clinical trial. [2011.04]
BACKGROUND: Thoracic epidural anaesthesia (EDA) is regarded as the 'gold standard' for postoperative pain control and restoration of pulmonary function after lung surgery. Easier, less time-consuming, and, perhaps, safer is intercostal nerve block performed under direct vision by the surgeon before closure of the thoracotomy combined with postoperative i.v. patient-controlled analgesia with morphine. We hypothesized that this technique is as effective as thoracic EDA... CONCLUSIONS: In patients undergoing lung surgery, single intercostal nerve block plus i.v. patient-controlled analgesia with morphine is not as effective as patient-controlled EDA with respect to pain control and restoration of pulmonary function.
Clinical Trials Related to Depodur (Morphine Epidural)
Depodur vs Fentanyl Infusion for Post-C/S Analgesia [Not yet recruiting]
Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement [Recruiting]
The investigators hypothesize that patients who receive a femoral catheter with low dose
epidural Depodur will experience comparable or superior pain relief than those who receive
both femoral and sciatic catheters. In addition, the investigators hypothesize that the one
catheter will be less time consuming to place and facilitate early ambulation of the
Clinical Study of Depodur Efficacy in Decreasing Post Operative Pain After Off Pump Coronary Artery Bypass Grafting (OP-CABG) [Not yet recruiting]
The purpose of this study is to determine whether epidural Depodur alleviates the pain of
OP-CABG surgery. This includes pain associated with sternotomy, retraction, dissection and
other tissue insults, as well as the induced inflammatory system and effects from prolonged
ventilation in the ICU setting.
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children [Recruiting]
The purpose of this proposal is to improve the investigators' current Selective Dorsal
Rhizotomy (SDR) analgesia protocol by eliminating or minimizing the use of fentanyl in the
Children undergoing SDR for spastic cerebral palsy have significant post-operative pain.
The procedure requires dissection of the lumbar back musculature and removal of the L1
lamina (the bony posterior part of the vertebra). The majority of the operation is
intradural, and a water-tight dural closure at the termination of the operation is critical
in order to prevent leakage of cerebrospinal fluid (CSF) from the wound. In fact, these
children must remain flat on their back for 48 hours to allow the dural incision to heal
prior to mobilization. Thus, adequate pain control is essential not only for patient
comfort, but also to prevent agitation and additional stress on the dural closure.
Currently, the investigators' patients undergoing SDR are treated for 48 hours with
scheduled intravenous (IV) narcotic (continuous fentanyl infusion at 0. 5-2. 0 μg/kg/hour) in
addition to the sedative/muscle relaxant Valium (0. 2 mg/kg IV every 4 hours for 24 hours,
then every 6 hours for 24 hours). The IV fentanyl, and to a lesser degree Valium, carries a
real risk of hypotension and respiratory depression and requires frequent dose adjustments
to achieve adequate analgesia.
By improving the current SDR analgesia protocol, the investigators hope to maximize patient
safety and comfort while maintaining the effectiveness of the operation by minimizing the
risk of CSF leak.