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Depo-Provera (Medroxyprogesterone Acetate) - Summary



DEPO-PROVERA Contraceptive Injection contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration.

DEPO-PROVERA Contraceptive Injection is indicated only for the prevention of pregnancy. To ensure that DEPO-PROVERA Contraceptive Injection is not administered inadvertently to a pregnant woman, the first injection must be given ONLY during the first 5 days of a normal menstrual period; ONLY within the first 5-days postpartum if not breast-feeding, and if exclusively breast-feeding, ONLY at the sixth postpartum week. The efficacy of DEPO-PROVERA Contraceptive Injection depends on adherence to the recommended dosage schedule (see DOSAGE AND ADMINISTRATION). It is a long-term injectable contraceptive in women when administered at 3-month (13-week) intervals. Dosage does not need to be adjusted for body weight.
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Published Studies Related to Depo-Provera (Medroxyprogesterone)

Differential effects of estrogen and micronized progesterone or medroxyprogesterone acetate on cognition in postmenopausal women. [2011.08]
OBJECTIVE: To investigate possible differential effects of the coadministration of conjugated equine estrogen (CEE) and a placebo (CEE + PL), CEE and medroxyprogesterone acetate (CEE + MPA), or CEE and micronized P (CEE + MP) on aspects of cognitive functioning in naturally postmenopausal women...

Effects of percutaneous estradiol-oral progesterone versus oral conjugated equine estrogens-medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women. [2011.03.01]
In a prospective, randomized clinical study 77 women were assigned randomly to receive sequential hormone therapy with either conventional oral conjugated equine estrogens (0.625 mg) with the addition on 14 of the 28 days of oral medroxyprogesterone acetate (5 mg) or natural E(2) gel (1.5 mg) with oral micronized P (200 mg) on 14 of the 28 days of each cycle.

Differential effects of estrogen and micronized progesterone or medroxyprogesterone acetate on cognition in postmenopausal women. [2011]
OBJECTIVE: To investigate possible differential effects of the coadministration of conjugated equine estrogen (CEE) and a placebo (CEE + PL), CEE and medroxyprogesterone acetate (CEE + MPA), or CEE and micronized P (CEE + MP) on aspects of cognitive functioning in naturally postmenopausal women... These findings need to be replicated with a larger sample size before their potential clinical implications can be determined.

Levonorgestrel-releasing intrauterine system or medroxyprogesterone for heavy menstrual bleeding: a randomized controlled trial. [2010.09]
OBJECTIVE: To compare the efficacy and safety of the levonorgestrel-releasing intrauterine system and oral medroxyprogesterone acetate in the treatment of idiopathic heavy menstrual bleeding... CONCLUSION: In women with idiopathic heavy menstrual bleeding, the levonorgestrel-releasing intrauterine system reduces menstrual blood loss more effectively and has a higher likelihood of treatment success than oral medroxyprogesterone acetate. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00360490. LEVEL OF EVIDENCE: I.

Vaginal estrogen supplementation during Depo-Provera initiation: a randomized controlled trial. [2010.09]
BACKGROUND: Irregular bleeding is often cited as the reason for discontinuation of depot-medroxyprogesterone acetate (DMPA) after the first injection. Estrogen supplementation during DMPA initiation may decrease bleeding and improve continuation... CONCLUSIONS: Vaginal estrogen supplementation during DMPA initiation is acceptable to women and may decrease total bleeding. Copyright 2010 Elsevier Inc. All rights reserved.

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Clinical Trials Related to Depo-Provera (Medroxyprogesterone)

Depo-Medroxyprogesterone Acetate (DMPA, Depo-Provera) Use With Certain Anti-HIV Drugs in HIV-Infected Women [Completed]
The purpose of this study is to look at the level of depo-medroxyprogesterone acetate (DMPA or Depo-Provera) in the blood to see if is affected by certain anti-HIV drugs (nelfinavir [NFV], efavirenz [EFV], indinavir [IDV] in combination with ritonavir [RTV], and nevirapine [NVP]). This study will also look at the levels of these anti-HIV drugs to see if they are affected by DMPA.

DMPA is a hormonal birth control method that is given as an injection. It is not known if taking DMPA together with anti-HIV drugs changes the amount of DMPA and/or the amount of anti-HIV drugs in the blood. If higher levels of DMPA occur, side effects may increase. If lower levels of anti-HIV drugs occur, the drugs may become less effective against HIV. This study will look at the levels of anti-HIV drugs and DMPA in the blood when these medications are used together.

Depo-Provera: Bone Mineral Density and Total Body Calcium in Adolescent DP150CI Users and Non-Hormonal Contraception [Completed]
To evaluate and compare Bone Mineral Density (BMD) in adolescent Depo-Provera Contraceptive Injection (DP150CI) users during depo medroxyprogesterone acetate (DMPA) therapy and following discontinuation of DMPA. Another group electing non-hormonal contraception or abstinence will be recruited as a reference population, across all study sites. The primary variable is BMD, measured by Dual Energy X-ray Absorptiometry (DXA). Secondary variables are: Total Body Composition& Total Body Calcium (TBC), measured by Dual Energy X-ray Absorptiometry (DXA), and surrogate biologic BMD markers. Safety will be evaluated by adverse event reporting, laboratory evaluations, pregnancies, weight and vital signs.

Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding Continuation, Contraceptive Continuation, and Postpartum Depression [Not yet recruiting]
In the United States, depot medroxyprogesterone acetate (DMPA) is given to women after delivery and before hospital discharge with the belief that women who delay starting DMPA may be more likely to become pregnant when they are not yet ready to be pregnant and that giving DMPA before discharge has little to no negative effect on breastfeeding. Administering DMPA to breastfeeding women has not been widely questioned because the limited existing studies do not show any adverse impact of DMPA on breastfeeding. However, these studies used inappropriate control groups and did not control for prior lactation experience.

The investigators plan to enroll 184 women who are planning to breastfeed and use DMPA after delivery to find out whether the timing of postpartum administration of DMPA (prior to hospital discharge or 4-6 weeks after delivery) affects the duration or exclusivity of breastfeeding among women who plan to breastfeed their infants. The investigators will also look at rates of use of highly effective contraception (defined as DMPA, intrauterine device, implant, sterilization, or lactational amenorrhea) and postpartum depression.

Modulation of Mucosal and Systemic Immunity by Hormonal Contraceptives [Recruiting]
The investigators are conducting a research study to understand how cells responsible for fighting infection (immune cells) are affected by hormonal contraceptive use. The investigators hypothesize that progestin-containing hormonal contraceptives (i. e., Depo-Provera) inhibit host response to infection. To test this hypothesis, the investigators will collect blood and genital tract samples from women before and after their initiation of a hormonal contraceptive (either birth control pills, Depo-Provera, or Mirena).

Acceptability of Depo-subQ Provera 104 in Uniject vs. Intramuscular Depo-Provera Among HIV+ Women & Providers, Uganda [Not yet recruiting]
The purpose of this study is to assess acceptability and side effects of a low-dose injectable contraceptive formulation which is delivered under the skin (subcutaneously), as compared with injectable contraception delivered into the muscle (intramuscularly) among adult HIV-positive women who attend mobile clinics for HIV care and wish to use injectable contraception. The investigators will also assess experiences experiences delivering these two types of injections among health care providers working within the HIV care clinics.

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Reports of Suspected Depo-Provera (Medroxyprogesterone) Side Effects

Headache (41)Menorrhagia (41)Drug Ineffective (39)Unintended Pregnancy (39)Weight Increased (36)Depression (30)Fatigue (29)Amenorrhoea (27)Anxiety (25)Alopecia (24)more >>


Based on a total of 13 ratings/reviews, Depo-Provera has an overall score of 5.31. The effectiveness score is 9.69 and the side effect score is 5.38. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Depo-Provera review by 28 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   Birth Control
Dosage & duration:   150mg/ml taken every 10-13 weeks for the period of for 9 years
Other conditions:   none
Other drugs taken:   OTC pain relievers
Reported Results
Benefits:   I was taking this drug as birth control, and it has been extremely effective. (No children, yet!) The fact that you only need to take it four times a year is great, so it is difficult to miss a dose. (Unlike the pill, which you take everyday, and missing it even once alters it's effectiveness.) As an added bonus, I no longer have my period, which were extremely painful and disrupted my life for a whole week every month. I no longer suffer from PMS symptoms, either. I can not complain about this drug at all.
Side effects:   I have not experienced any side effects from this medication. Losing my period was an anticipated side effect, and although many feel that this is too much for them and discontinue use of this drug, it is a good side effect for me. Also there are studies that show bone mineral density is affected by this drug, but I have undergone a bone density scan, with normal results. This is great, considering I have been on Depo for nine years now, since I turned nineteen and for most of my twenties.
Comments:   This drug is administered into a muscle by injection four times a year, by a physician. The shot is given every ten to thirteen weeks. Besides being used as birth control, it is also used to treat other conditions.


Depo-Provera review by 42 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   contraception
Dosage & duration:   1 shot every three months (dosage frequency: 8 times) for the period of 2 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   It was 100% effectiv as contraception, the mayor benefit is not having to rememeber to take the pill every day and that it has only one form of hormon, which is important for woman over 35, especially smokers.
Side effects:   The side effects were like a prevision of menopause - huge weight gain (20 pounds), incredible mood swings and severe bloating. My overall feeling was quite depressed and it took me a while to figure out that it had to do with the drug, not with what was going on in my personal life. I also thought that the weight gain was partially retlated to quiting smking.
Comments:   One shot in the upper arm every three months, that's it!


Depo-Provera review by 29 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   contraception pill
Dosage & duration:   1 injection every 3 months (dosage frequency: as above) for the period of 6 months
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   prevented pregnancy as it is a form of contraceptive but unfortunately it takes away your libido and sex drive
Side effects:   weight gain:25kg in 3 weeks,never recovered my original weight and it has been 9 years now.it blocks your sex drive not to say it cuts it off completely,depression
Comments:   one injection and my life turned to hell as started to bloat like a milking cow,lost self esteem and fiance,lost friends,lost will to live,no sex drive,no self love

See all Depo-Provera reviews / ratings >>

Page last updated: 2013-02-10

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