ADVERSE REACTIONS
The following adverse reactions have been reported with Depo-Medrol or other corticosteroids:
Allergic reactions: Allergic or hypersensitivity reactions, anaphylactoid reaction, anaphylaxis, angioedema
Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopthy in premature infants, myocardial rupture following recent mycocardial infarction (see WARNINGS), pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.
Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increase sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.
Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.
Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, Fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.
Gastrointestinal: Abdominal distention, bowel/bladder dysfunction (after intrathecal administration), elevation in serum liver enzymes levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible subsequent perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.
Metabolic: Negative nitrogen balance due to protein catabolism.
Musculoskeletal: Aseptic necrosis of femoral and humeral heads, calcinosis (following intra-articular or intra-lesional use), Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare (following intra-articular use), steroid myopathy, tendon rupture, vertebral compression fractures.
Neurologic/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.
Ophthalmic: Exophthalmoses, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.
Other: Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, injection site infections following non-sterile administration (see WARNINGS), malaise, moon face, weight gain.
The following adverse reactions have been reported with the following routes of administration:
Intrathecal/Epidural: Arachnoiditis, bowel/bladder dysfunction, headache, meningitis, parapareisis/paraplegia, seizures, sensory disturbances.
Intranasal: Allergic reactions, rhinitis, temporary/permanent visual impairment including blindness.
Ophthalmic: Increased intraocular pressure, infection, ocular and periocular inflammation including allergic reactions, residue or slough at injection site, temporary/permanent visual impairment including blindness.
Miscellaneous injection sites: (scalp, tonsillar fauces, sphenopalatine ganglion): Blindness
|
REPORTS OF SUSPECTED DEPO-MEDROL SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Depo-Medrol. The information is not vetted and should not be considered as verified clinical evidence.
Possible Depo-Medrol side effects / adverse reactions in 34 year old female
Reported by a physician from Japan on 2011-10-03
Patient: 34 year old female
Reactions: Malaise, Cataract, Retinal Detachment, Restlessness
Suspect drug(s):
Solu-Medrol
Dosage: 1000 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
Depo-Medrol
Dosage: 20 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
Trimethoprim
Dosage: 20 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
Possible Depo-Medrol side effects / adverse reactions in 61 year old female
Reported by a physician from United States on 2011-10-10
Patient: 61 year old female
Reactions: Incorrect Route of Drug Administration, Headache, Convulsion
Suspect drug(s):
Conray
Dosage: unk
Start date: 2011-03-07
Depo-Medrol
Dosage: 40 mg, unk
Start date: 2011-03-07
Other drugs received by patient: Effexor; Pravastatin
Possible Depo-Medrol side effects / adverse reactions in 34 year old female
Reported by a physician from Japan on 2011-10-10
Patient: 34 year old female
Reactions: Cataract, Retinal Detachment
Suspect drug(s):
Depo-Medrol
Dosage: 20 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
Trimethoprim
Dosage: 20 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
Solu-Medrol
Dosage: 1000 mg, unk
Indication: Vogt-Koyanagi-Harada Syndrome
|
