WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT DEPO-ESTRADIOL (AN ESTROGEN HORMONE)?
Estrogens increase the chances of getting cancer of the uterus.
Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterine (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.
Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. You and your healthcare provider should talk regularly about whether you still need treatment with DEPO-Estradiol.
DEPO-Estradiol Injection contains estradiol cypionate for intramuscular use. Each mL contains: 5 mg/mL - 5 mg estradiol cypionate, 5.4 mg chlorobutanol anhydrous (chloral derivative) added as preservative; in 913 mg cottonseed oil. Warning: Chlorobutanol may be habit forming.
DEPO-Estradiol Injection is indicated in the treatment of:
- Moderate to severe vasomotor symptoms associated with the menopause.
- Hypoestrogenism due to hypogonadism.
Media Articles Related to Depo-Estradiol (Estradiol)
Hormone Therapy: No Effect on Cognition After Menopause
Source: Medscape NeurologyHeadlines [2016.07.21]
The first randomized trial to look specifically at timing of hormone therapy with estradiol on cognition has shown no effect in early or late postmenopausal women.
Medscape Medical News
Published Studies Related to Depo-Estradiol (Estradiol)
Sexual function in women on estradiol or venlafaxine for hot flushes: a
randomized controlled trial. 
estradiol or venlafaxine for hot flushes... CONCLUSION: Overall sexual function among nondepressed midlife women experiencing
Effect of estradiol valerate on endometrium thickness during clomiphene
citrate-stimulated ovulation. 
CONCLUSIONS: We concluded that the addition of 6 mg/day EV following the CC
[Efficacy and safety of a combined oral contraceptive containing drospirenone 3
mg and ethinylestradiol 20 µg in the treatment of premenstrual dysphoric
disorder: a randomized, double blind placebo-controlled study]. [Article in Chinese] 
with placebo in reducing symptoms of premenstrual dysphoric disorder (PMDD)... CONCLUSIONS: YAZ could improve symptoms of PMDD better than placebo, while
Effects of tibolone or continuous combined oestradiol/norethisterone acetate on
glucose and insulin metabolism. 
insulin metabolism in postmenopausal women... CONCLUSIONS: Tibolone reduces insulin sensitivity. Healthy postmenopausal women
Impact of estradiol valerate/dienogest on work productivity and activities of
daily living in women with heavy menstrual bleeding. 
estradiol valerate/dienogest (E2V/DNG; Qlaira(®)/Natazia(®)) compared to placebo... CONCLUSIONS: E2V/DNG was shown to have a consistent positive impact on work
Reports of Suspected Depo-Estradiol (Estradiol) Side Effects
Poor Quality Drug Administered (4),
Feeling Hot (3),
Drug Ineffective (2),
Ingrown Hair (2),
Drug Ineffective FOR Unapproved Indication (1),
Skin Ulcer (1), more >>
Page last updated: 2016-07-21